Dual antiretroviral regimen maintains durable HIV suppression after switch

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People who switched from standard antiretroviral therapy to a two-drug regimen of dolutegravir (Tivicay) plus rilpivirine (Edurant) were able to maintain an undetectable viral load for 48 weeks in a pair of late-stage clinical trials, according to a late-breaking report at the 2017 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle.

As long as people with HIV face the prospect of lifelong treatment, researchers will continue to look for antiretroviral regimens that are easier to take and more affordable, while remaining highly effective and well tolerated. If this can be accomplished with two instead of three or more drugs, treatment could be simpler and the cost could be lower. But simplifying therapy too much raises the risk of treatment failure and drug resistance.

Josep Llibre of University Hospital Germans Trias in Barcelona presented findings from the SWORD-1 and -2 trials, which evaluated whether dolutegravir plus rilpivirine could maintain viral suppression in treatment-experienced people who switched from a three- or four-drug regimen with undetectable virus.

“It’s been a long-term dream to try to find safe strategies that can control the disease with a reduced number of drugs,” Llibre said.

ViiV Healthcare’s dolutegravir is a potent integrase inhibitor with a high barrier to resistance, making it a good candidate for simplified therapy. Janssen’s rilpivirine is a well tolerated second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI).

Prior studies suggested that this approach is feasible.

As reported at the International AIDS Conference last July, the PADDLE pilot study showed that a dual regimen of dolutegravir plus the inexpensive nucleoside reverse transcriptase inhibitor (NRTI) lamivudine (3TC or Epivir) led to sustained undetectable viral load in most people starting ART for the first time (the phase 3 GEMINI trial is evaluating this regimen in a larger study).

Another small study suggested that dolutegravir alone might be enough to maintain viral suppression in some highly treatment-experienced patients. Previous studies looked at monotherapy or dual therapy using boosted protease inhibitors, but these agents have more side effects and drug-drug interactions than integrase inhibitors.

SWORD-1 and SWORD-2 were identical multicentre randomised trials with enrolment from Europe, Russia, North and South America, and Asia. Together the studies included 1024 people with HIV who had been on standard ART with undetectable viral load (HIV RNA)

More than three-quarters were men, most were white, the median age was 43 years and the baseline CD4 T-cell count was approximately 600 cells/mm3. At study entry they were on regimens containing at least three drugs: an integrase inhibitor (20%), NNRTI (54%) or protease inhibitor (26%) plus two NRTIs; 73% used tenofovir disoproxil fumarate. People with chronic hepatitis B co-infection were excluded.

Participants in these open-label studies were randomly assigned (1:1) either to switch to the dual regimen of once-daily dolutegravir plus rilpivirine or to stay on their current regimen. The primary endpoint was continued undetectable viral load at 48 weeks.

Most participants in both treatment arms maintained viral suppression; 95% of people in the dolutegravir plus rilpivirine arm and 95% in the unchanged regimen arm had HIV RNA below 50 copies/ml at 48 weeks, showing that switching to the dual regimen was non-inferior to staying on standard therapy.

Virological failure was rare, <1% in the dual therapy arm and 1% in the unchanged regimen arm. Among those who underwent viral sequencing, one person taking dolutegravir plus rilpivirine had a NNRTI resistance mutation, but no one in either arm had integrase resistance mutations.

Treatment was generally safe and well tolerated. No unexpected drug-related adverse events were reported. Serious adverse events were comparable in both arms, but discontinuations due to adverse events occurred more often in the dual therapy arm (3% vs <1%). The most common adverse events were nasopharyngitis (inflammation of the nose and throat), headache, upper respiratory tract infections and diarrhoea. Although the frequency of more severe (grade 3-4) adverse events did not differ between the two arms, there were more mild to moderate (grade 1-2) events reported in the dolutegravir plus rilpivirine arm (17% vs 2%).

Joseph Eron of the University of North Carolina at Chapel Hill suggested that this may reflect the fact that people who switch drugs often blame any symptoms on their new medications, while those who stay on the same treatment might not bother to report common minor symptoms such as headache or sore throat.

Switching to the dual regimen had a beneficial in terms of bone biomarkers and a neutral effect on lipids, according to Llibre. This former may be due to the fact that many switched off of tenofovir DF, which is known to cause bone loss.

“This is the first time we can prove [a two-drug regimen] is non-inferior in a once-daily regimen with no booster, no protease inhibitor and no NRTIs.” Llibre said.

The SWORD studies are continuing through 148 weeks. A new trial will assess a fixed-dose co-formulation of dolutegravir plus rilpivirine – described as a very small pill – as once-daily single-tablet regimens are now the standard of care for a majority of people with HIV. This study will enrol some people with pre-existing drug resistance, to better reflect a ‘real world’ population.

Abstract
The requirement for life-long antiretroviral therapy (ART) of HIV infection has highlighted interest in 2-drug regimens (2DR) to minimize cumulative drug exposure. Dolutegravir’s (DTG) potency, safety and resistance barrier make it an optimal core agent for 2DR. Rilpivirine’s (RPV) safety, tolerability and efficacy in switch regimens make it an ideal potential partner.
Two identical open-label, multicenter, global, phase III, non-inferiority studies evaluated the efficacy and safety of switching from a 3 or 4-drug current antiretroviral regimen (CAR) to DTG+RPV once daily in HIV-1-infected adults, with HIV-1 RNA
1024 pts were randomized and exposed (DTG+RPV 513; CAR 511), across both studies. Switching to DTG+RPV was non-inferior to continuing CAR at Wk48 for VL
A switch to a novel, once daily 2DR of DTG+RPV demonstrated high efficacy and was non-inferior to the continuation of CAR in virologically suppressed HIV-1-infected adults. The safety profiles of both DTG and RPV were consistent with the respective labels. A DTG+RPV 2DR offers the potential for reduction in cumulative ART exposure, without an increased risk of virologic failure.

Authors
Josep M Llibre, Chien-Ching Hung, Cynthia Brinson, Francesco Castelli, Pierre-Marie Girard, Lesley Kahl, Elizabeth Blair, Brian Wynn, Kati Vandermeulen, Michael Aboud

Aidsmap material
CROI 2017 abstract


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