Prednisone reduces TB-IRIS risk in HIV patients

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Patients with HIV had significantly less risk for clinical deterioration due to tuberculosis–related inflammation when given prednisone early in their treatment regimen in a recent study.

The placebo-controlled trial tested whether prednisone safely reduced the risk of TB–associated immune reconstitution inflammatory syndrome (TB-IRIS) in patients at high risk for the disease.

“The implications of our study are that this is the first evidence-based option for reducing the risk of TB-IRIS in high-risk patients with HIV and TB starting ART,” study researcher Dr Graeme Meintjes, professor of medicine at the University of Cape Town, South Africa said at the the Conference on Retroviruses and Opportunistic Infections (CROI 2017), in Seattle.

Abstract
Early initiation of antiretroviral therapy (ART) in patients with TB reduces mortality in those with low CD4 counts, but increases the risk of paradoxical TB-IRIS. Prednisone reduces symptoms when used to treat TB-IRIS. We determined whether prophylactic prednisone in patients at high risk for paradoxical TB-IRIS safely reduces the incidence of TB-IRIS.
1:1 randomized, double-blind, placebo-controlled trial of prednisone (40 mg/day for 2 weeks then 20 mg/day for 2 weeks) started with ART in ART-naïve adults at high risk of TB-IRIS (within 30 days of TB treatment initiation and CD4 count ≤100/μl) followed for 12 weeks. Exclusion criteria included rifampicin resistance, neurological TB, Kaposi’s sarcoma, hepatitis BsAg+ and poor clinical response to TB treatment. Primary endpoint was development of TB-IRIS, defined using the International Network for the Study of HIV-associated IRIS (INSHI) consensus case definition, adjudicated by an independent committee. Final results are presented.
240 participants were enrolled: median age 36.8 (IQR=30-42.8), 60% men, median CD4 49/μl (IQR=24-86), and median HIV RNA 337,775 copies/ml (IQR=162,223-810,812). TB was microbiologically confirmed in 175. 18 were lost to follow-up or withdrew. TB-IRIS fulfilling INSHI criteria was diagnosed in 56 in the placebo arm (46.7%) and 39 in the prednisone arm (32.5%) (p=0.02, relative risk (RR)=0.70 (95%CI=0.51-0.96)). Open label corticosteroids to treat TB-IRIS was prescribed as necessary in 34 of the placebo arm (28.3%) and 16 (13.3%) of the prednisone arm (RR=0.47 (95%CI=0.27-0.83)). 4 deaths occurred in the placebo arm (1 attributed to TB-IRIS) and 5 in the prednisone arm (p=1.0). 27 were hospitalized (all-cause) in the placebo arm compared with 17 in the prednisone arm (p=0.10). Grade 3 adverse events occurred more frequently in the placebo arm (45.4% vs 29.4%, p=0.01), but grade 4 adverse events were similar by arm (8.4% vs 7.6%, p=0.81). Severe infections (AIDS-defining or invasive bacterial) occurred in 18 in the placebo arm and 11 in the prednisone arm (p=0.17). There was a trend towards fewer interruptions of ART or TB treatment in the prednisone arm (8.3% vs 15.8%, p=0.07).
In patients at high risk of paradoxical TB-IRIS, prednisone during the first 4 weeks of ART reduced the risk of TB-IRIS by 30% and further reduced the requirement for corticosteroids to treat TB-IRIS by 53%. The intervention was well-tolerated with no excess risk of infection or malignancy.

Authors
Graeme Meintjes, Cari Stek, Liz Blumenthal, Friedrich Thienemann, Charlotte Schutz, Jozefien Buyze, Gary Maartens, Robert Wilkinson, Lutgarde Lynen

Healio report
CROI 2017 abstract (81LB)


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