Significant attrition at each stage of HIV care

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There is significant attrition at each stage of the HIV care continuum in South Africa, according to population-based research conducted in North West Province.

The study revealed that of those with HIV, only 48% of men and 76% of women were aware they were infected. Patients were then lost at each stage in the cascade of HIV care. Overall, just 22% of HIV-positive men and 56% of HIV-positive women had viral suppression, liberally defined as a viral load below 5,000 copies/ml.

“These results provide a comprehensive picture of engagement with HIV care from diagnosis to viral suppression in a geographic area with little previous research but extremely high burden of disease,” write Sheri Lippman, assistant professor at the University of California, San Francisco School of Medicine and colleagues. “Based on the full HIV-positive population, it is quite clear that the greatest gap in engagement occurs at HIV diagnosis, indicating a critical need for improving case detection, particularly among men.”

South Africa has the largest antiretroviral therapy (ART) delivery programme in the world. Yet despite a massive scale-up in the delivery of ART, approximately 200,000 South Africans still die of Aids each year and only half of those eligible for antiretroviral treatment are receiving appropriate treatment.

There are currently very limited data on engagement of patients in South Africa with the HIV care continuum. Population-based evidence is especially scarce. A team of investigators therefore conducted a population-based study involving adults aged between 18 and 49 years in a rural districts of North West Province. The area is known to have a high HIV prevalence (in excess of 20%).

Data were gathered between January and March 2014 in Lewka-Teemane and Greater Taung sub-districts. A total of 1,044 individuals were included in the household-based survey and provided blood samples for rapid HIV testing, point-of-care CD4 cell monitoring and dried blood spots for viral load assessment. Participants were asked if they had ever tested for HIV, if they knew if they were HIV positive, and if so, whether they had ever been linked to care, if they were retained in care, if they were taking ART and if they were adherent to ART.

The investigators defined the HIV care continuum as follows: undiagnosed or newly diagnosed – HIV-positive patients with no reported previous test or a prior negative test; linked to care – reported ever seeing a doctor/nurse for HIV care; ideal linkage to care – saw a healthcare provider and had a CD4 count within three months of diagnosis; retained in care – if eligible for ART, reported being on therapy and seeing a healthcare provider every three months in the past year; if not ART eligible, reported seeing a care provider and receiving a CD4 count in the past year; adherent to ART – reported taking 90% or more of prescribed doses and no treatment interruptions; and viral suppression – viral load below 5,000 copies/ml.

Overall, 20% of men and 27% of women were HIV positive. Over half (52%) of men and a quarter of men diagnosed with HIV were previously unaware of their infection status. Of those with HIV, only 44% of men and 75% of women reported ever linking to HIV care, and 40% of women and 29% of men had been linked to care and received a CD4 cell count within three months of diagnosis. Just one-third of men and 58% of women were retained in care, the majority of whom had started ART.

Although 33% of ART-treated men and 53% of women taking HIV therapy reported being fully adherent to their treatment, just 22% of men and 50% of women had a viral load below 5,000 copies/ml.

Then investigators focused on engagement with the care continuum among patients who already knew they were HIV positive. The majority (99% of women and 91% of men) was ever linked to care, but only 60% connected with care within three months of their diagnosis. Of those linked to care, 75% of men and 78% of women were retained in care. The majority of ART-treated patients (97% of men and 92% of women) reported being adherent to their therapy, but only 29% of men and 60% of women had a viral load below 5000 copies/ml. Only 26% had viral suppression when a threshold of 1000 copies/ml was used.

“Our findings demonstrate high reported adherence, but low rates of viral suppression, indicating a potential bias in self-reporting adherence data, which could be due to social desirability bias or over-reporting of medication adherence, as well as medication failure,” suggest the researchers.

They conclude that their data “provide a comprehensive picture of the HIV care continuum in the North West province and should be utilised to inform targeted programming.” Although noting that attrition occurs at every stage of the care continuum, the investigators suggest the most urgent need “is for improved HIV detection, particularly among men.”

Abstract
Background: Attrition along the HIV care continuum slows gains in mitigating the South African HIV epidemic. Understanding population-level gaps in HIV identification, linkage, retention in care and viral suppression is critical to target programming.
Methods: We conducted a population-based household survey, HIV rapid testing, point-of-care CD4 testing, and viral load measurement from dried blood spots (DBS) using multi-stage cluster sampling in two sub-districts of North West Province from January-March, 2014. We used weighting and multiple imputation of missing data to estimate HIV prevalence, undiagnosed infection, linkage and retention in care, medication adherence, and viral suppression.
Results: We sampled 1044 respondents ages 18-49. HIV prevalence was 20.0% (95% CI: 13.7-26.2) for men and 26.7% (95%CI: 22.1-31.4) for women. Among those HIV-positive, 48.4% of men and 75.7% of women were aware of their serostatus; 44.0% of men and 74.8% of women reported ever linking to HIV care; 33.1% of men and 58.4% of women were retained in care; and 21.6% of men and 50.0% of women had DBS viral loads < 5000 copies/mL. Among those already linked to care, 81.7% on ART and 56.0% of those not on ART were retained in care and 51.8% currently retained in care on ART had viral loads < 5000 copies/mL.
Conclusions: Despite expanded treatment in South Africa, attrition along the continuum of HIV care is slowing prevention progress. Improved detection is critically needed, particularly among men. Reported linkage and retention is reasonable for those on ART, however failure to achieve viral suppression is worrisome.

Authors
Lippman, Sheri A; Shade, Starley B; El Ayadi, Alison M; Gilvydis, Jennifer M; Grignon, Jessica S; Liegler, Teri; Morris, Jessica MA; Naidoo, Evasen; Prach, Lisa M; Puren, Adrian; Barnhart, Scott

Aidsmap material
Journal of Acquired Immune Deficiency Syndromes abstract


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