Less educated have poorer outcomes after starting cART

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People with HIV who have lower educational attainment have poorer outcomes after starting combination antiretroviral therapy (cART), according to data from a large European cohort collaboration.

Rates of mortality and Aids decreased with increasing education level, and education was also associated with virological suppression and CD4 count at the time of cART initiation.

“The striking differences in mortality and clinical responses to cART could not be explained entirely by delayed HIV diagnosis or late cART initiation, since differences largely remained after we restricted analyses to those initiating cART with CD4> 350 cells/mm3 and without previous Aids diagnoses,” comment the authors led by Julia Del Amo, National Centre of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain. “The associations we found between educational level and clinical outcomes are probably mediated by material and psychosocial paths.”

Even in countries with free access to healthcare, lower socioeconomic group is associated with poorer health outcomes. Investigators from a large collaboration of HIV cohort studies – the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) – have already shown that late diagnosis of HIV and starting cART with a low CD4 count are associated with lower levels of education. The researchers now wanted to see if disparities in health outcomes by education persisted after cART initiation.

They therefore designed a study examining differences by educational level in mortality and new Aids after starting cART and also viral suppression and CD4 count changes. Data from 15 cohort studies in eight countries were available for analysis. Adult patients starting cART for the first time between 1996 and 2013 were eligible for inclusion. Educational level was standardised across the cohorts.

The main outcomes were: all cause mortality; new Aids event or death; virological suppression – two successive viral load measurements below 400 copies/ml; and CD4 cell increases during the first six years of cART.

Results were adjusted to take account of sex, age at cART initiation, calendar period of cART initiation (before 2001; 2001-04; 2005-08; 2009-13), transmission category, pre-cART viral load and CD4 count; pre-cART Aids and type of cART.

A total of 24,069 people were eligible for inclusion. Overall, 9% had not completed primary education; 32% had only a primary education; 44% had completed secondary education and 14% had a college education or equivalent.

Individuals with a secondary and college education were more likely to be male and in the men-who-have-sex-with-men transmission category. A fifth of women were in the lower educational strata.

There was an association between education and mortality. During 132,507 person-years of analysis, 1081 people died. Mortality decreased as educational level increased (p < 0.001) and these differences persisted in models that adjusted for potential confounders. People with a college education had a lower risk of death than all other educational groups. A similar mortality pattern was present in an analysis controlling for CD4 count at the time of cART initiation, previous Aids and age at the time treatment was started.

A significant association was also present between education and mortality and Aids. Over 122,765 person-years, there were 2598 new Aids events or deaths. Differences in incidence of Aids/death by educational level were even more marked than for death alone (p < 0.001).

One year after starting HIV therapy, 77% of patients had attained viral suppression. This was achieved by 67% of people with incomplete primary education, 85% of individuals with a primary education, 82% of individuals with a secondary education and 87% of individuals who had attended college (p < 0.001). Differences in outcomes between the groups became less pronounced over time and ceased to be significant after ten years of therapy. After adjusting for possible confounders, those with an incomplete primary education or a primary education only had 20% and 7% lower chances, respectively, of attaining a virological response than patients who attended college.

Turning to immunological outcomes, the data showed that the higher the educational level achieved, the higher the CD4 count at cART initiation. However, there was no evidence that educational level was associated with CD4 count recovery six months after starting therapy.

“HIV-positive patients on combination antiretroviral therapy who had less education had higher mortality, higher rates of new Aids, and worse virological responses than patients under care who had more education,” write the authors. “We observed such health differentials for an eighteen-year period in eight European countries where access to health care and cART is universal.”

Background: Socioeconomic inequality challenges population-level implementation of health interventions. We investigated differences by educational level in clinical, virological and immunological responses to combined Antiretroviral Treatment (cART) in HIV-positive men and women in COHERE, a European collaboration.
Methods: Data were pooled from 15 cohorts in eight countries of patients initiating cART in 1996-2013 with data on educational level categorized in UNESCO/ISCED classifications. Kaplan-Meier curves, Cox and piecewise linear mixed models were used.
Results: Of 24,069 HIV-positive patients, 9% had not completed primary education, 32% had completed primary, 44% secondary, and 15% tertiary education. Overall, 21% were women, who were over-represented in lower educational strata. During 132,507 person-years of follow-up, 1,081 individuals died; cumulative mortality decreased with higher educational level (p < 0.001). Over 122,765 person-years, new AIDS events or death occurred in 2,598 individuals; differences by education were more marked than for death alone (p < 0.001). Virological response was achieved by 67% of patients without completed basic education, 85% with completed primary education, 82% with secondary, and 87% with tertiary (p < 0.001). Patients with higher education had higher CD4-count at cART initiation and at each time after cART but rate of CD4-count recovery did not differ. Differences in mortality and clinical responses were similar for men and women and were not entirely explained by delayed HIV diagnosis and late cART initiation.
Conclusions: HIV-positive patients with lower educational level had worse responses to cART and survival in European countries with universal healthcare. To maximize the population impact of cART, Europe needs to decrease the socioeconomic divide.

Del Amo, Julia

AIDS journal abstract

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