No or low risk of HIV transmission from spitting and biting

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SpittingThere is no risk of transmitting HIV through spitting, and the risk from biting is negligible, according to research. An international team of investigators at the clinical research department, London School of Hygiene and Tropical Medicine, clinical research department,  Infectious Diseases Institute, Kampala, Uganda and the Lawson Unit, Royal Sussex County Hospital, Brighton, conducted a meta-analysis and systematic review of reports of HIV transmission attributable to spitting or biting. No cases of transmission due to spitting were identified and there were only four highly probable cases of HIV being transmitted by a bite.

The study was motived by the use of spit hoods by police forces in the UK because of the perceived risk of the transmission of HIV and other blood-borne viruses from spitting. The researchers’ findings endorse the position of the National AIDS Trust and Hepatitis C Trust that neither HIV nor hepatitis C virus can be transmitted by spitting, and that the use of spit hoods by police forces to protect offices against these viruses cannot be justified.

“We undertook a systematic literature review of HIV transmission related to biting or spitting to ensure that decisions about future policy and practice pertaining to biting and spitting incidents are informed by current medical evidence,” explain the study’s authors. They identified published studies and conference presentations reporting on transmission of HIV via spitting or biting. Inclusion criteria were: discussion of transmission by biting or spitting; outcome described by documented HIV antibody test. Two reviewers independently identified studies that were included in the full analysis.

There were no cohort or case-control studies. The investigators therefore assessed the plausibility of HIV being transmitted to a spitting or biting incident according to baseline HIV status, nature of the injury, temporal relationship between the incident and HIV test, and where, available, phylogenetic analysis.

The plausibility of transmission being related to an incident was categorised as high, medium or low. A total of 742 studies and case reports were reviewed by the authors. There were no reported cases of HIV transmission attributable to spitting. A total of 13 studies reported on HIV transmission and biting. The studies consisted of eleven case reports and two case series relating to HIV transmission, or its absence, after a biting incident.

None of the possible cases of HIV transmission due to biting were in the UK or involved emergency workers. The reports included information on 23 individuals, of whom nine (39%) seroconverted for HIV. Six of these cases involved family members, three involved fights resulting in serious wounds, and two were the result of untrained first-aiders placing fingers in the mouth of an individual experiencing a seizure.

“Of the 742 records reviewed, there was no published cases of HIV transmission attributable to spitting, which supports the conclusion that being spat on by an HIV-positive individual carries no possibility of transmitting HIV,” write the authors. “Despite biting incidents being commonly reported occurrences, there were only a handful of case reports of HIV transmission secondary to a bite, suggesting that the overall risk of HIV transmission from being bitten by an HIV-positive person is negligible.”

There were only four highly plausible cases of HIV transmission resulting from a bite. In each case, the person with HIV had advanced disease and was not on combination antiretroviral therapy and was therefore likely to have had a high viral load. The bite caused a deep wound and the HIV-positive person had blood in their mouth.

“Two cases occurred in the context of a seizure whereby an untrained first-aid responder was bitten while trying to protect the seizing person’s airway,” note the researchers. “It is therefore important that both emergency workers and first-aid responders are trained in safe seizure management including non-invasive airway protection and use universal precautions.”

The investigators emphasise that they found no cases of an emergency worker or police officer being infected with HIV because of a bite. They point out that bite injuries are a common reason for attending accident and emergency departments: a review of A&E admissions over a four-year period at a hospital in the UK found that one person was admitted with a bite wound every three days, on average.

“Current UK guidance on indications for PEP (post-exposure prophylaxis, emergency HIV therapy after a high-risk exposure to HIV) state that ‘PEP is not recommended following a human bite from an HIV-positive individual unless in extreme circumstances and after discussion with a specialist,’” conclude the authors. “Necessary conditions for transmission of HIV from a human bite appear to be the presence of untreated HIV infection, severe trauma (involving puncture of the skins), and usually the presence of blood in the mouth of the biter. In the absence of these conditions, PEP is not indicated, as there is no risk of transmission.”

Abstract
Objectives: The perceived threat of HIV transmission through spitting and biting is evidenced by the increasing use of “spit hoods” by Police Forces in the UK. In addition, a draft parliamentary bill has called for increased penalties for assaults on emergency workers, citing the risk of communicable disease transmission as one justification. We aimed to review literature relating to the risk of HIV transmission through biting or spitting.
Methods: A systematic literature search was conducted using Medline, Embase and Northern Lights databases and conference websites using search terms relating to HIV, AIDS, bite, spit and saliva. Inclusion and exclusion criteria were applied to identified citations. We classified plausibility of HIV transmission as low, medium, high or confirmed based on pre‐specified criteria.
Results: A total of 742 abstracts were reviewed, yielding 32 articles for full‐text review and 13 case reports/series after inclusion and exclusion criteria had been applied. There were no reported cases of HIV transmission related to spitting and nine cases identified following a bite, in which the majority occurred between family (six of nine), in fights involving serious wounds (three of nine), or to untrained first‐aiders placing fingers in the mouth of someone having a seizure (two of nine). Only four cases were classified as highly plausible or confirmed transmission. None related to emergency workers and none were in the UK.
Conclusions: There is no risk of transmitting HIV through spitting, and the risk through biting is negligible. Post‐exposure prophylaxis is not indicated after a bite in all but exceptional circumstances. Policies to protect emergency workers should be developed with this evidence in mind.

Authors
FV Cresswell, J Ellis, J Hartley, CA Sabin, C Orkin, DR Churchill

Aidsmap material
HIV Medicine abstract


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