Reducing alcohol could help people to quit smoking, research finds

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People wanting to quit smoking might want to consider cutting back on their drinking, too. According to Oregon State University research, heavy drinkers who are trying to stop smoking may find that reducing their alcohol use can also help them quit their daily smoking habit.

Heavy drinkers’ nicotine metabolite ratio – a biomarker that indicates how quickly a person’s body metabolizes nicotine – reduced as they cut back on their drinking.

Past research has suggested that people with higher nicotine metabolism ratios are likely to smoke more and that people with higher rates have a harder time quitting. Slowing a person’s nicotine metabolism rate through reduced drinking could provide an edge when trying to stop smoking, which is known to be a difficult task, said Sarah Dermody, an assistant professor at Oregon State University and the study’s lead author.

“It takes a lot of determination to quit smoking, often several attempts,” Dermody said. “This research suggests that drinking is changing the nicotine metabolism as indexed by the nicotine metabolite ratio, and that daily smoking and heavy drinking may best be treated together.”

The study was just published in the journal Nicotine & Tobacco Research.

Dermody, who is based in in the School of Psychological Science in OSU’s College of Liberal Arts, studies risky behaviours such as alcohol and nicotine use with the goal of better understanding factors that contribute to alcohol and nicotine use and how best to intervene with problematic use of these substances.

Use of both alcohol and cigarettes is widespread, with nearly 1 in 5 adults using both. Cigarette use is especially prevalent in heavy drinkers. Drinking is a well-established risk factor for smoking, and smoking is well-established risk factor for drinking.

Dermody and colleagues at the Centre for Addiction and Mental Health in Toronto, Canada, wanted to better understand the links between the two. They studied the nicotine metabolite ratio, an index of nicotine metabolism, in a group of 22 daily smokers who were seeking treatment for alcohol use disorder – the medical term for severe problem drinking – over several weeks.

“What’s really interesting is that the nicotine metabolite ratio is clinically useful,” Dermody said. “People with a higher ratio have a harder time quitting smoking cold turkey. They are also less likely to successfully quit using nicotine replacement therapy products.”

They found that as the men in the study group reduced their drinking – from an average of 29 drinks per week to 7 – their nicotine metabolite rate also dropped. The researchers’ findings for men replicated those of an earlier study that found similar effects and provide further evidence of the value of the nicotine metabolite ratio biomarker to inform treatment for smokers trying to quit, Dermody said.

“The nicotine metabolite ratio was thought to be a stable index, but it may not be as stable as we thought,” Dermody said. “From a clinical standpoint, that’s a positive thing, because if someone wants to stop smoking, we may want to encourage them to reduce their drinking to encourage their smoking cessation plan.”

The women in the study did not see reductions in their nicotine metabolite ratio, but the researchers also did not find that the women in the study reduced their drinking significantly during the study period. “The rate of drinking for women in the study started low and stayed low,” Dermody said. “I anticipate that in a larger generalized study we would not see the difference between men and women like that.”

Dermody is preparing a new study of the links between smoking and drinking. She hopes to recruit heavy drinkers who also smoke to participate in an intervention to reduce their drinking. The study will also examine the effects on smoking to try and replicate the findings in a larger group.

“This research is demonstrating the value in addressing both smoking and drinking together,” she said. “The question now is how best to do that.”

Abstract

Introduction: Alcohol may influence the nicotine metabolite ratio (NMR), an index of the rate of nicotine metabolism that is associated smoking level and lapses. We examined if NMR changes during alcohol use disorder (AUD) treatment and how changes in NMR relate to reductions in drinking.

Methods

Using an observational design, 22 daily smokers (63.64% male, Mage=46.77 (11.37)) receiving AUD treatment completed baseline and follow-up appointments three weeks apart. At each appointment, daily alcohol and cigarette use, salivary and urinary NMR, nicotine exposure via urinary total nicotine equivalents (TNE), and carbon monoxide (CO) were assessed. Multilevel models examined the change over time in NMR and its within-person relations with changes in drinks per week. Sex differences were evaluated.

Results

There were significant reductions in both salivary and urinary NMR over time for men (p=.02; p=.01, respectively) but not for women (p=.54; p=.90). There were no changes over time in TNE (p=.09), CO (p=.44), or cigarette use (p=.44), in either sex. Drinks per week were significantly reduced for men (29.12 drink reduction, p<.001) but not for women (2.28 drink reduction, p=.80); however, within-person changes in drinking were not associated with changes in salivary or urinary NMR (p=.99; p=.19).

Conclusions

The reduction in alcohol use and NMR in men provides indirect support for alcohol increasing NMR. In contrast, the low baseline drinking and lack of alcohol reduction likely underlies the lack of change in NMR in females. Reasons for NMR reductions during AUD treatment and its effects on smoking require further study.

Implications

Three weeks of alcohol use disorder treatment among daily smokers coincided with both a significant reduction in alcohol use and a significant reduction in the nicotine metabolite ratio (NMR) for men, however, neither drinking level or NMR changed for women. The findings indirectly support that heavy drinking increases NMR, which is reversed with reduced drinking. Additional research is needed to establish if these changes in NMR correlate with smoking and cessation outcomes.

Authors
Sarah S Dermody, Christian S Hendershot, Allyson K Andrade, Maria Novalen, Rachel F Tyndale

Oregon State University material
Nicotine and Tobacco Research abstract


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