Smoking lessens effect of breast cancer Tx

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A research study from Lund University in Sweden shows that treatment with aromatase inhibitors for breast cancer works less well in patients who smoke, compared to non-smokers.

“Smokers who were treated with aromatase inhibitors had a three times higher risk of recurrence of breast cancer compared with the non-smokers who got the same treatment. The study also showed that the smokers also had an increased risk of dying, either from the breast cancer or from other illnesses, during the time we followed them”, says Helena Jernström, associate professor and researcher who, together with trainee physician Mia Persson, is the principal investigator behind the study.

The researchers followed 1,016 patients in southern Sweden who were diagnosed with breast cancer between 2002 and 2012. At the time when they were booked in for surgery, they were asked whether they were smokers or non-smokers. Approximately one in five women stated that she was either a regular smoker or a “social smoker”. The impacts of smoking were analysed depending on what type of breast cancer treatment the patients received after their surgeries.

What the study shows most clearly is that women over the age of 50, treated with aromatase inhibitors, are affected by smoking. This treatment against breast cancer prevents the body from generating oestrogen in fatty tissue and thereby reduces the risk of recurrence in women with oestrogen-receptive positive breast cancer.

“The treatment with aromatase inhibitors worked significantly better in the non-smoking patients. However, we saw little or no difference between smokers and non-smokers among patients treated with the drug tamoxifen, radiotherapy or chemotherapy. More studies are needed, but our findings are important as many breast cancer patients receive this type of treatment”, says Jernström.

One finding which surprised the researchers was that so few patients quit smoking during their treatment, despite being informed of the importance of doing so. Out of a total of 206 smokers, only 10% stopped smoking in the first year after their surgery, a number so small that the researchers could not study whether giving up smoking during treatment had any effect.

“That was unexpected. Smoking is not health-promoting in any way, after all, so it is always beneficial to stop. But these findings show that patients who smoke need more support and encouragement to quit.” says Jernström.

Abstract
Background: The association between smoking and breast cancer prognosis remains unclear. The purpose of this study was to investigate whether preoperative smoking was associated with prognosis in different treatment groups.
Methods: This population-based cohort consisted of 1065 breast cancer patients without preoperative treatment included between 2002 and 2012 in Lund, Sweden. Smoking status was examined in relation to patient and tumour characteristics, and prognosis in different treatment groups.
Results: At the preoperative visit, 21.0% smoked. Median follow-up time was 5.1 years. Overall, in the 1016 patients included in the survival analyses, there was no significant association between smoking and risk of breast cancer events (adjusted hazard ratio (adjHR): 1.45; 95% confidence interval (CI): 0.95–2.20). For the 309 aromatase inhibitor (AI)-treated patients 50 years with oestrogen receptor-positive (ER+) tumours, smoking was associated with risk of breast cancer events (adjHR: 2.97; 95% CI: 1.44–6.13), distant metastasis (adjHR: 4.19; 95% CI: 1.81–9.72), and death (adjHR: 3.52; 95% CI: 1.59–7.81). Smoking was not associated with breast cancer events or distant metastasis in other treatment groups.
Conclusions: Preoperative smoking was only associated with an increased risk for breast cancer events and distant metastasis in AI-treated patients. If confirmed, smoking status should be taken into consideration when selecting an endocrine therapy.

Authors
Mia Persson, Maria Simonsson, Andrea Markkula, Carsten Rose, Christian Ingvar and Helena Jernström

Lund University material
British Journal of Cancer abstract


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