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WHO update on COVID-19 vaccines: 180 candidates in 35 trials

The World Health Organisation updated its website on 9 September on COVID-19 vaccine candidates with a line listing of 180 different candidates including 35 in clinical trials and 145 still in pre-clinical stage.

Of the 35 vaccine candidates in clinical trials (Phase 1, 2 and/or 3), WHO has listed nine with links to their Phase 3 protocols. These nine Phase 3 vaccine protocols are listed with study sites involving countries in Asia, Europe, North America, South America, and Africa. Some of these vaccine candidate Phase 3 trials currently involve one nation (US, Russia, Pakistan, Indonesia, Brazil, UAE), while other Phase 3 protocols are multinational.

This useful Draft landscape of COVID-19 candidate vaccines includes separate columns for: Vaccine developer/manufacturer, Vaccine platform, Type of vaccine and Number of doses.

The nine candidate vaccines and (vaccine platforms), in the order listed on this WHO website are:
University of Oxford/AstraZeneca: (Non-Replicating Viral Vector)
CanSino Biological Inc/Beijing Institute of Biotechnology: (Non-Replicating Viral Vector)
Gamaleya Research Institute: (Non-Replicating Viral Vector)
Janssen Pharmaceutical Companies: (Non-Replicating Viral Vector), but ”not yet recruiting”
Sinovac: (Inactivated)
Wuhan Institute of Biological Products/Sinopharm: (Inactivated)
Beijing Institute of Biological Products/Sinopharm: (Inactivated)
Moderna/NIAID: (RNA)
BioNTech/Fosun Pharma/Pfizer: (RNA)

Although one of these Phase 3 vaccine candidates (University of Oxford/AstraZeneca) has been on hold (no vaccinations being given) over the past three days due to a neurological adverse event in one volunteer in the UK that is under investigation to determine whether or not it was causally related to the vaccine, multiple other Phase 3 studies are ongoing.

 

[link url="https://sciencespeaksblog.org/2020/09/11/who-website-lists-nine-phase-3-vaccine-candidate-protocols-around-the-world/"]Science Speaks blog[/link]

 

[link url="https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines"]WHO COVID-19 candidate vaccines[/link]

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