Air pollution increases death risk in patients with mental disorders

Organisation: Position: Deadline Date: Location:

FoggyHongKongThe risk of death for people with mental and behavioural disorders rises sharply on days when air pollution reaches toxic peaks, The Guardian reports a major study in Hong Kong has found. Researchers analysed a decade of death statistics and revealed a strong link, with the mortality risk rising 16% on the first day of haze and 27% on the second day compared to normal days. If the haze was accompanied by high ozone pollution, the risk of death increased by 79%.

The report says the new research tallies with other recent work that has found links between short-term increases in air pollution and suicides. However, scientists do not yet understand how air pollution may cause these effects and they are urging more research, as well as immediate help for those at risk.

“First of all, we need more support to those high-risk groups,” said Lin Yang, at Hong Kong Polytechnic University and one of the research team. “Currently we have a lot of social workers to give support to people with mental disorders. But they probably need to pay attention to the fact that haze events could be a trigger for acute onset of symptoms.”

“Of course, as a priority, what governments need to do is control air pollution. That is the best way to eradicate the problem – from the source,” she said.

Professo4 Jonathan Grigg, at Queen Mary University of London in the UK and not part of the research team, said: “The association between poor air quality and mortality due to mental and behavioural disorders reported in this study is very disturbing.”

The report says the Hong Kong research is the first to analyse the link of haze days and risk of death. Haze days are those on which pollutants gather in the air and cut visibility, usually dry days with low winds. In the study period from 2007 to 2014, there were 111 haze days when particle pollution was on average twice as high.

The scientists examined more than 284,000 deaths, including those among people with mental and behavioural disorders including depression, bipolar, schizophrenia and dementia.

“Although a hazy day generally has 2.9% higher risk (of death) than a day without haze, a very intense adverse effect is found on the mortality associated with mental and behaviour disorders,” the researchers reported. “A combined influence of haze, extreme weather/air quality and urban environment can result in extremely high mortality.”

“From the mechanism point of view, for now, we don’t have very solid evidence or hypotheses,” said Yang. But she said earlier work may provide clues: “Haze days are very likely to trigger an acute depression response in people. This has been shown in surveys in 2013 in Indonesia, where there was a big disaster of haze from forest fires.”

Lin also said laboratory studies on mice show that small particles of air pollution can reach the brain and affect mental development. A study published in 2016 found toxic nanoparticles from air pollution in human brains in “abundant” quantities.

Sophie Neuburg, at the public health charity Medact, is quoted in the report as saying: “The new report’s findings of an increase in mortality associated with mental and behavioural disorders on high-pollution days is extremely worrying. This is a sign that air pollution may be even more dangerous for human health than we currently understand.” She said the UK’s air is illegally polluted in most urban areas and that current policies to deal with it are “inadequate”.

The Hong Kong study did not specifically analyse suicides but Grigg said: “Although we do not yet understand how pollutants inhaled into the lung affect cognitive function, these new findings from Asia are compatible with a recent Belgian study, which reported an association between short-term increases in air pollution and suicide.”

That work examined over 20,000 suicide deaths recorded between 2002 and 2011 and was published in June 2017. The scientists reported: “[Short-term] increases in outdoor air pollutants such as particles or ozone can trigger suicide, particularly during warm periods, even at concentrations below the European thresholds.”

A series of other studies published since 2015 have also suggested links between suicides and air pollution. In Salt Lake City, Utah, US, increases in suicides correlated with higher particulates and nitrogen dioxide (NO2) in some seasons, while in South Korea ozone was also implicated.

In Tokyo, Japan, scientists found elevated suicide risk among under-30s was linked to NO2 and in Guangzhou, China, sulphur dioxide also showed a correlation. However, some scientists have urged caution, saying that collecting comprehensive data on suicides is difficult and that both air pollution and suicides can vary with other factors, such as time of day.

Abstract
Haze is an extreme weather event that can severely increase air pollution exposure, resulting in higher burdens on human health. Few studies have explored the health effects of haze, and none have investigated the spatiotemporal interaction between temperature, air quality and urban environment that may exacerbate the adverse health effects of haze.
We investigated the spatiotemporal pattern of haze effects and explored the additional effects of temperature, air pollution and urban environment on the short-term mortality risk during hazy days. We applied a Poisson regression model to daily mortality data from 2007 through 2014, to analyze the short-term mortality risk during haze events in Hong Kong. We evaluated the adverse effect on five types of cause-specific mortality after four types of haze event. We also analyzed the additional effect contributed by the spatial variability of urban environment on each type of cause-specific mortality during a specific haze event. A regular hazy day (lag 0) has higher all-cause mortality risk than a day without haze (odds ratio: 1.029 [1.009, 1.049]). We have also observed high mortality risks associated with mental disorders and diseases of the nervous system during hazy days. In addition, extreme weather and air quality contributed to haze-related mortality, while cold weather and higher ground-level ozone had stronger influences on mortality risk. Areas with a high-density environment, lower vegetation, higher anthropogenic heat, and higher PM2.5 featured stronger effects of haze on mortality than the others. A combined influence of haze, extreme weather/air quality, and urban environment can result in extremely high mortality due to mental/behavioral disorders or diseases of the nervous system.
In conclusion, we developed a data-driven technique to analyze the effects of haze on mortality. Our results target the specific dates and areas with higher mortality during haze events, which can be used for development of health warning protocols/systems.

Authors
Hung ChakHo, Man SingWong, LinYangcWenzhongShi, JinxinYang, MuhammadBilal, Ta-Chien Chan

The Guardian report
Environmental International abstract
European Journal of Epidemiology abstract


Receive Medical Brief's free weekly e-newsletter



Related Posts

Thank you for subscribing to MedicalBrief


MedicalBrief is Africa’s premier medical news and research weekly newsletter. MedicalBrief is published every Thursday and delivered free of charge by email to over 33 000 health professionals.

Please consider completing the form below. The information you supply is optional and will only be used to compile a demographic profile of our subscribers. Your personal details will never be shared with a third party.


Thank you for taking the time to complete the form.