Fast and deadly spread of C.auris hits SA also

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CandidaA drug-resistant fungus called Candida auris, which preys on people with weakened immune systems, is quietly spreading across the globe, reports The New York Times. The US Centres for Disease Control and Prevention has added it to a list of germs deemed “urgent threats”.

Over the last five years, it has hit a neonatal unit in Venezuela, swept through a hospital in Spain, forced a prestigious British medical centre to shut down its intensive care unit, and taken root in India, Pakistan and South Africa.

Last May, an elderly man was admitted to the Brooklyn branch of Mount Sinai Hospital for abdominal surgery. A blood test revealed that he was infected with a newly discovered germ as deadly as it was mysterious. Doctors swiftly isolated him in the intensive care unit.

Recently, the report says, C. auris reached New York, New Jersey and Illinois, leading the US Centres for Disease Control and Prevention to add it to a list of germs deemed “urgent threats.”

The report say the man at Mount Sinai died after 90 days in the hospital, but C. auris did not. Tests showed it was everywhere in his room, so invasive that the hospital needed special cleaning equipment and had to rip out some of the ceiling and floor tiles to eradicate it. “Everything was positive – the walls, the bed, the doors, the curtains, the phones, the sink, the whiteboard, the poles, the pump,” said Dr Scott Lorin, the hospital’s president. “The mattress, the bed rails, the canister holes, the window shades, the ceiling, everything in the room was positive.” C. auris is so tenacious, in part, because it is impervious to major anti-fungal medications, making it a new example of one of the world’s most intractable health threats: the rise of drug-resistant infections.

For decades, the report says, public health experts have warned that the overuse of antibiotics was reducing the effectiveness of drugs that have lengthened life spans by curing bacterial infections once commonly fatal. But lately, there has been an explosion of resistant fungi as well, adding a new and frightening dimension to a phenomenon that is undermining a pillar of modern medicine.

“It’s an enormous problem,” said Matthew Fisher, a professor of fungal epidemiology at Imperial College London. “We depend on being able to treat those patients with antifungals.”

The report says simply put, fungi, just like bacteria, are evolving defences to survive modern medicines.

Yet even as world health leaders have pleaded for more restraint in prescribing antimicrobial drugs to combat bacteria and fungi – convening the UN General Assembly in 2016 to manage an emerging crisis – gluttonous overuse of them in hospitals, clinics and farming has continued.

Resistant germs are often called “superbugs,” but this is simplistic because they don’t typically kill everyone. Instead, the report says, they are most lethal to people with immature or compromised immune systems, including new-borns and the elderly, smokers, diabetics and people with autoimmune disorders who take steroids that suppress the body’s defences.

Scientists say that unless more effective new medicines are developed and unnecessary use of antimicrobial drugs is sharply curbed, risk will spread to healthier populations. A study the British government funded projects that if policies are not put in place to slow the rise of drug resistance, 10m people could die worldwide of all such infections in 2050, eclipsing the eight million expected to die that year from cancer.

In the US, 2m people contract resistant infections annually, and 23,000 die from them, according to the official CDC estimate. That number was based on 2010 figures; more recent estimates from researchers at Washington University School of Medicine put the death toll at 162,000. Worldwide fatalities from resistant infections are estimated at 700,000.

The report says antibiotics and antifungals are both essential to combat infections in people, but antibiotics are also used widely to prevent disease in farm animals, and antifungals are also applied to prevent agricultural plants from rotting. Some scientists cite evidence that rampant use of fungicides on crops is contributing to the surge in drug-resistant fungi infecting humans.

Yet as the problem grows, it is little understood by the public – in part because the very existence of resistant infections is often cloaked in secrecy. With bacteria and fungi alike, hospitals and local governments are reluctant to disclose outbreaks for fear of being seen as infection hubs. Even the CDC, under its agreement with states, is not allowed to make public the location or name of hospitals involved in outbreaks. State governments have in many cases declined to publicly share information beyond acknowledging that they have had cases.

The report says all the while, the germs are easily spread – carried on hands and equipment inside hospitals; ferried on meat and manure-fertilised vegetables from farms; transported across borders by travellers and on exports and imports; and transferred by patients from nursing home to hospital and back.

The report says c. auris, which infected the man at Mount Sinai, is one of dozens of dangerous bacteria and fungi that have developed resistance. Other prominent strains of the fungus Candida – one of the most common causes of bloodstream infections in hospitals – have not developed significant resistance to drugs, but more than 90% of C. auris infections are resistant to at least one drug, and 30% are resistant to two or more drugs, the CDC said.

Dr Lynn Sosa, Connecticut’s deputy state epidemiologist, said in the report that she now saw C. auris as “the top” threat among resistant infections. “It’s pretty much unbeatable and difficult to identify,” she said. Nearly half of patients who contract C. auris die within 90 days, according to the CDC.

Yet the world’s experts have not nailed down where it came from in the first place. “It is a creature from the black lagoon,” said Dr Tom Chiller, who heads the fungal branch at the CDC, which is spearheading a global detective effort to find treatments and stop the spread. “It bubbled up and now it is everywhere.”

The report says in late 2015, Dr Johanna Rhodes, an infectious disease expert at Imperial College London, got a panicked call from the Royal Brompton Hospital, a British medical centre in London. C. auris had taken root there months earlier, and the hospital couldn’t clear it. “‘We have no idea where it’s coming from. We’ve never heard of it. It’s just spread like wildfire,’” Rhodes said she was told. She agreed to help the hospital identify the fungus’s genetic profile and clean it from rooms.

Under her direction, hospital workers used a special device to spray aerosolised hydrogen peroxide around a room used for a patient with C. auris, the theory being that the vapor would scour each nook and cranny. They left the device going for a week. Then they put a “settle plate” in the middle of the room with a gel at the bottom that would serve as a place for any surviving microbes to grow, Rhodes said.

The report says only one organism grew back. C. auris. It was spreading, but word of it was not. The hospital, a specialty lung and heart centre that draws wealthy patients from the Middle East and around Europe, alerted the British government and told infected patients, but made no public announcement. “There was no need to put out a news release during the outbreak,” said Oliver Wilkinson, a spokesperson for the hospital.

The report says this hushed panic is playing out in hospitals around the world. Individual institutions and national, state and local governments have been reluctant to publicise outbreaks of resistant infections, arguing there is no point in scaring patients – or prospective ones.

Dr Silke Schelenz, Royal Brompton’s infectious disease specialist, found the lack of urgency from the government and hospital in the early stages of the outbreak “very, very frustrating.” “They obviously didn’t want to lose reputation,” Schelenz said. “It hadn’t impacted our surgical outcomes.”

By the end of June 2016, the report says a scientific paper reported “an ongoing outbreak of 50 C. auris cases” at Royal Brompton, and the hospital took an extraordinary step: It shut down its ICU for 11 days, moving intensive care patients to another floor, again with no announcement. Days later the hospital finally acknowledged to a newspaper that it had a problem. (Later research said there were eventually 72 total cases, though some patients were only carriers and were not infected by the fungus.)

Yet the issue remained little known internationally, while an even bigger outbreak had begun in Valencia, Spain, at the 992-bed Hospital Universitari i Politècnic La Fe. The report says there, unbeknown to the public or unaffected patients, 372 people were colonised – meaning they had the germ on their body but were not sick with it – and 85 developed bloodstream infections. A paper reported that 41% of the infected patients died within 30 days.

A statement from the hospital said it was not necessarily C. auris that killed them. “It is very difficult to discern whether patients die from the pathogen or with it, since they are patients with many underlying diseases and in very serious general condition,” the statement said.

The report says as with Royal Brompton, the hospital in Spain did not make any public announcement. It still has not. One author of the paper, a doctor at the hospital, said in an email that the hospital did not want him to speak to journalists because it “is concerned about the public image of the hospital.”

The secrecy infuriates patient advocates, who say people have a right to know if there is an outbreak so they can decide whether to go to a hospital, particularly when dealing with a non-urgent matter, like elective surgery. “Why the heck are we reading about an outbreak almost a year and a half later — and not have it front-page news the day after it happens?” Dr Kevin Kavanagh, a physician in Kentucky and board chair of Health Watch USA, a non-profit patient advocacy group is quoted in the report as saying. “You wouldn’t tolerate this at a restaurant with a food poisoning outbreak.”

Health officials say that disclosing outbreaks frightens patients about a situation they can do nothing about, particularly when the risks are unclear. “It’s hard enough with these organisms for health care providers to wrap their heads around it,” said Dr Anna Yaffee, a former CDC outbreak investigator who dealt with resistant infection outbreaks in Kentucky in which the hospitals were not publicly disclosed. “It’s really impossible to message to the public.”

The report says officials in London did alert the CDC to the Royal Brompton outbreak while it was occurring. And the CDC realised it needed to get the word to US hospitals. On 24 June, 2016, the CDC blasted a nationwide warning to hospitals and medical groups and set up an email address, candidaauris@cdc.gov, to field queries. Dr Snigdha Vallabhaneni, a key member of the fungal team, expected to get a trickle – “maybe a message every month.” Instead, within weeks, her inbox exploded.

The report says, according to the CDC, in the US, 587 cases of people having contracted C. auris have been reported, concentrated with 309 in New York, 104 in New Jersey and 144 in Illinois. The symptoms – fever, aches and fatigue – are seemingly ordinary, but when a person gets infected, particularly someone already unhealthy, such commonplace symptoms can be fatal.

As the CDC works to limit the spread of drug-resistant C. auris, its investigators have been trying to answer the vexing question: Where in the world did it come from?

The report says the first time doctors encountered C. auris was in the ear of a woman in Japan in 2009 (auris is Latin for ear). It seemed innocuous at the time, a cousin of common, easily treated fungal infections. Three years later, it appeared in an unusual test result in the lab of Dr Jacques Meis, a microbiologist in Nijmegen, the Netherlands, who was analysing a bloodstream infection in 18 patients from four hospitals in India. Soon, new clusters of C. auris seemed to emerge with each passing month in different parts of the world.

The CDC investigators theorized that C. auris started in Asia and spread across the globe. But, the report says, when the agency compared the entire genome of auris samples from India and Pakistan, Venezuela, South Africa and Japan, it found that its origin was not a single place, and there was not a single auris strain.

The genome sequencing showed that there were four distinctive versions of the fungus, with differences so profound that they suggested that these strains had diverged thousands of years ago and emerged as resistant pathogens from harmless environmental strains in four different places at the same time. “Somehow, it made a jump almost seemingly simultaneously, and seemed to spread and it is drug resistant, which is really mind-boggling,” Vallabhaneni said.

The report says there are different theories as to what happened with C. auris. Meis said he believed that drug-resistant fungi were developing thanks to heavy use of fungicides on crops. Meis became intrigued by resistant fungi when he heard about the case of a 63-year-old patient in the Netherlands who died in 2005 from a fungus called Aspergillus. It proved resistant to a front-line antifungal treatment called itraconazole. That drug is a virtual copy of the azole pesticides that are used to dust crops the world over and account for more than one-third of all fungicide sales.

A 2013 paper said that it appeared to be no coincidence that drug-resistant Aspergillus was showing up in the environment where the azole fungicides were used. The fungus appeared in 12% of Dutch soil samples, for example, but also in “flower beds, compost, leaves, plant seeds, soil samples of tea gardens, paddy fields, hospital surroundings, and aerial samples of hospitals.”

The report says Meis visited the CDC last summer to share research and theorise that the same thing is happening with C. auris, which is also found in the soil: Azoles have created an environment so hostile that the fungi are evolving, with resistant strains surviving. This is similar to concerns that resistant bacteria are growing because of excessive use of antibiotics in livestock for health and growth promotion. As with antibiotics in farm animals, azoles are used widely on crops.

“On everything — potatoes, beans, wheat, anything you can think of, tomatoes, onions,” said Rhodes. “We are driving this with the use of antifungicides on crops.”

The report says Chiller theorises that C. auris may have benefited from the heavy use of fungicides. His idea is that C. auris actually has existed for thousands of years, hidden in the world’s crevices, a not particularly aggressive bug. But as azoles began destroying more prevalent fungi, an opportunity arrived for C. auris to enter the breach, a germ that had the ability to readily resist fungicides now suitable for a world in which fungi less able to resist are under attack.

The report says the mystery of C. auris’s emergence remains unsolved, and its origin seems, for the moment, to be less important than stopping its spread.

The New York Times report

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