Testing for fever, high pulse rate, crackly breath sounds, and low oxygen levels could be key to helping GPs distinguish difficult to diagnose pneumonia from less serious infections, according to a large UK study. Pneumonia is a severe lung infection that can be life-threatening and often requires treatment with antibiotics. However, it is notoriously difficult to discriminate from more common viral infections, against which antibiotics are ineffective.
The researchers say that using these four measures could help patients get the treatment they need as well as reducing unnecessary antibiotic use, which is fuelling a rise in drug-resistant infections.
The study was led by Michael Moore, professor of primary care research at the University of Southampton, and funded by the National Institute for Health Research.
He explained: “GPs see a huge number of patients with symptoms of a lower respiratory tract infection such as coughing, phlegm, wheezing and being short of breath. The vast majority of these will have a viral infection, which can range from being mild through to feeling extremely unwell. But antibiotics do not work well for these patients and have side effects, so they should be avoided.
“On the other hand, around one in 20 patients will have pneumonia. Again, there is a spectrum of how sick patients with pneumonia will be, but it can be a life-threatening condition that requires hospital treatment. Antibiotics can often be an effective treatment for pneumonia.
“It is notoriously difficult to tell one infection from the other. GPs fail to spot two out of every three cases of pneumonia, although those which are missed are the milder ones with less distinctive features. One of the reasons GPs offer antibiotics is that they are rightly concerned about missing a serious illness.
Moore and his colleagues studied 28,883 patients who had visited GPs at 5,222 different surgeries across the UK with signs of an infection in the lungs or airways, such as a cough. They collected data on the patients’ symptoms, results of any tests and details of any treatment given, and continued to monitor the patients for the following 30 days.
A total of 720 patients in the study went on to have a chest x-ray and of these, 115 were found to have pneumonia.
The researchers found that some signs and symptoms were more common in patients who turned out to have pneumonia. These were a temperature higher than 37.8°C, a crackling sound in the patient’s lungs, a pulse rate of more than 100 beats per minute, and oxygen saturation in the blood lower than 95%. They found that 86.1% of patients with pneumonia exhibited at least one of these signs.
Blood oxygen levels can be easily measured using a non-invasive device called a pulse oximeter, which fits over the end of a finger. However, pulse oximeters are relatively new to general practice and not used routinely because, until now, there has been no convincing evidence that they help to pick up pneumonia.
Moore said: “This study shows that there are objective measures that indicate whether or not a patient might have pneumonia, and they are all factors that GPs can already test for. Whereas other symptoms like sputum colour do not seem to help.
“This is the first large study to look at whether oxygen saturation might indicate pneumonia and the results do support using pulse oximetry in assessing patients in primary care. We can’t rule out that widespread use might result in more patients being referred to hospital. For this reason, it should be considered by GPs in conjunction with a clinical examination and other factors.”
He continued: “The rise in drug-resistant infections is an international priority and one of the contributors to antibiotic resistance is unnecessary prescribing. Most patients with a lower respiratory tract infection will recover perfectly well without antibiotics but, at the moment, around 60% of patients get a prescription.
“Finding ways of identifying those at low risk of complications should help reduce this figure. If antibiotic prescribing was restricted to people who had one or more of these signs it could result in a substantial reduction in unnecessary prescriptions for this condition.”
Although the study is large, the researchers caution that its main weakness is that it relied on routine x-rays to confirm the diagnosis of pneumonia. They point out that relatively few people had an x-ray and so milder cases of pneumonia would still have been missed.
Moore and his team continue to study these types of respiratory infections and they hope to test whether these findings can be implemented in routine general practice to improve diagnosis and focus antibiotic treatment on those who really need it.
Objective: To aid diagnosis of pneumonia in those presenting with lower respiratory tract symptoms in routine primary care.
Methods: A cohort of 28883 adult patients with acute cough attributed to LRTI was recruited from 5222 UK practices in 2009-13. Symptoms, signs and treatment were recorded at presentation and subsequent events followed-up for 30 days by chart review. The predictive value of patient characteristics, presenting symptoms, and clinical findings for the diagnosis of pneumonia in the first seven days was established.
Results: Of the 720/28883 (2.5.%) x-rayed within one week of the index consultation,115 (16.0%; 0.40% of 28883) were assigned a definite or probable pneumonia diagnosis. The significant independent predictors of X ray confirmed pneumonia were temperature >37.8 degrees (RR 2.6; 95%CI 1.5-4.8), crackles on auscultation (RR1.8; 1.1-3.0), oxygen saturation<95% (RR1.7; 1.0-3.1) and pulse >100/min (RR1.9; 1.1-3.2). Most patients with pneumonia (99/115, 86.1%) exhibited at least one of these four clinical signs; the positive predictive value of having at least one of these signs was 20.2% (95%CI 17.3-23.1).
Clinical Implications: In routine practice, x-ray confirmed pneumonia as a short term complication of LRTI is very uncommon (1 in 270). Pulse oximetry may aid the diagnosis of pneumonia in this setting.
Michael Moore, Beth Stuart, Paul Little, Sue Smith, Matthew J Thompson, Kyle Knox, Anne van den Bruel, Mark Lown, David Mant