The surgical procedure known as neck dissection to remove lymph nodes and receiving treatment at academic or research institutions was associated with improved survival in patients with stages I and II oral cavity squamous cell cancer (OCSCC), according to a new report.
There were about 28,000 cases of OCSCC in the US in 2014 and about 5,500 deaths predicted. About 60% of patients with OCSCC are initially seen with early stage disease (either I or II). Prognosis depends on many factors, including patient age, stage at diagnosis and the primary site of the disease, with an average five-year survival rate of 80%. Treatment of early OCSCC has not changed substantially in several decades and improvement in outcomes has been slow. The role of neck dissection in early OCSCC remains controversial, according to the study background.
Dr Benjamin L Judson, of the Yale University School of Medicine and co-authors analysed the associations between various treatment characteristics and survival in stages I and II OCSCC. The study was a review of cases in the National Cancer Data Base and included 6,830 patients. Survival at five years was 69.7% (4,760 patients), according to the study results.
The authors found neck dissection and treatment at academic or research institutions were associated with improved survival, while positive margins, insurance through Medicare or Medicaid, and radiation or chemotherapy were associated with reduced survival.
Patients treated at academic or research cancer centres were more likely to receive neck dissection and were less likely to receive radiation therapy or have positive margins than those patients treated at non-academic centres. "Identification of the underlying causes of these differences could reveal valuable targets for improvement of outcomes in early OCSCC," the study concludes.
[link url="http://media.jamanetwork.com/news-item/study-examines-treatment-factors-associated-with-oral-cavity-cancer-survival/"]JAMA material[/link]
[link url="http://archotol.jamanetwork.com/article.aspx?articleid=2291044"]JAMA Otolaryngology – Head & Neck Surgery abstract[/link]