Medical mycology groups set out aspergillosis treatment guidelines

Organisation: Position: Deadline Date: Location:

Several European medical mycology groups have joined to release guidelines to improve the clinical management of patients with aspergillosis.

The groups involved were: ESCMID-EFISG (ESCMID Fungal Infection Study Group); ESGICH (ESCMID Study Group for Infections in Compromised Hosts – ESGICH); ECMM (ECMM European Confederation of Medical Mycology); and ERS (European Respiratory Society).

Some of the key points are summarised as follows:
Diagnosis of invasive aspergillosis (IA)
Carry out chest CT and bronchoalveolar lavage
Test for galactomannan in serum and BAL
Pathogen identification
Identify all clinical isolates to species complex level and perform antifungal susceptibility testing in IA cases in regions where resistance is detected by surveillances programmes.
Direct microscopy (preferably using optical brighteners) histopathology and culture are strongly recommended.
PCR should be considered.
Antifungal therapy
Isavuconazole and voriconazole are the preferred agents for first-line treatment of pulmonary IA, whereas liposomal amphotericin B is moderately supported.
Combinations of antifungals as primary treatment options are not recommended.
Use therapeutic drug monitoring when treating with posaconazole suspension or any form or voriconazole
Prophylaxis
Primary prophylaxis with posaconazole is strongly recommended in patients with acute myelogenous leukaemia or myelodysplastic syndrome receiving induction chemotherapy.
Secondary prophylaxis is strongly recommended in high-risk patients.

Life-Worldwide material
Clinical Microbiology and Infection Guidelines


Receive Medical Brief's free weekly e-newsletter



Related Posts

Thank you for subscribing to MedicalBrief


MedicalBrief is Africa’s premier medical news and research weekly newsletter. MedicalBrief is published every Thursday and delivered free of charge by email to over 33 000 health professionals.

Please consider completing the form below. The information you supply is optional and will only be used to compile a demographic profile of our subscribers. Your personal details will never be shared with a third party.


Thank you for taking the time to complete the form.