Social smokers have multifold higher lung disease and lung cancer risk

Organisation: Position: Deadline Date: Location:

‘Social smokers’ are more than twice as likely to die of lung disease and more than eight times as likely to die of lung cancer than non-smokers, according to research from Columbia University presented at the virtual European Respiratory Society International Congress, held from 7-9 September 2020.

The study also shows that the risk of lung cancer death for ‘social smokers’ – those who smoke fewer than 10 cigarettes per day – is not substantially lower than those who smoke more than 20 cigarettes a day.

Researchers say their study suggests that cutting down, or combining fewer cigarettes with vaping, is no substitute for quitting, European Respiratory Society material reveals.

The research was led by Dr Pallavi Balte and Dr Elizabeth Oelsner at Columbia University Medical Center in New York. Balte told the virtual conference: “Everyone knows that smoking is bad for you, but it’s easy to assume that if you only smoke a little, the risks won’t be too high.

“Previous research suggests that people are cutting down on smoking, for example in the United States the proportion of smokers smoking less than 10 cigarettes per day has increased from 16% to 27%. So, we wanted to study the risks to social smokers compared to people who don’t smoke and compared to heavier smokers.”

The study

The study included 18,730 people selected from a multi-ethnic sample of the general US population with an average age of 61. Researchers followed the people for an average of 17 years, during which time 649 died of respiratory disease and 560 died of lung cancer.

Among non-smokers, the proportion of people who died from respiratory diseases was 1.8% and the proportion who died of lung cancer was 0.6%. Among social smokers (people who smoked fewer than 10 cigarettes a day), around 3.3% died from respiratory diseases and 4.7% died from lung cancer. For heavy smokers (people who smoked more than 20 cigarettes a day), these proportions were 10.1% and 12.9%, respectively.

The researchers calculated the death rates from respiratory disease and lung cancer and compared these rates between non-smokers, social smokers and heavy smokers. They took account of other factors that can influence death rates, such as age, sex, race, educational attainment and body weight.

They found that social smokers were 2.5 times as likely to die of respiratory disease and 8.6 times as likely to die of lung cancer, compared to non-smokers. Social smokers had around half the rate of death from respiratory disease as heavy smokers, but their rate of lung cancer death was two thirds that of heavy smokers.

No safe level of smoking

Dr Balte added: “You might think that if you only smoke a few cigarettes a day you are avoiding most of the risk. But our findings suggesting that social smoking is disproportionately harmful.

“Smoking is dangerous, regardless of whether you are a heavy smoker or a social smoker, so if you don’t want to die of lung cancer or respiratory disease, the best action is to quit completely.”

Dr Balte and her colleagues continue to study the effects of social smoking as well as investigating the effects of new habits such as vaping.

Jørgen Vestbo, who was not involved in the research, is Chair of the European Respiratory Advocacy Council and Professor of Respiratory Medicine at the University of Manchester in the United Kingdom. He said: “Although the proportion of people who smoke habitually is falling in many countries, we should still be concerned about those who identify as social smokers.

“Cutting down on smoking is a step in the right direction, as quitting tobacco is one of the best ways to protect the lungs and our overall health, but it’s clear that there is no safe level of smoking.”

“This large study is important because it shows that smoking less will probably not have the effect that people are hoping for. We need to do all we can to support smokers to quit completely using evidence-based means, for example with access to support services, and nicotine patches or gum.”

 

Association of low-intensity smoking with respiratory and lung cancer mortality

Oral presentation session: “From tobacco and vaping health effects to tobacco cessation”. Tuesday 8 September 2020. European Respiratory Association.

Authors

Pallavi Balte, Surya Bhatt, Paulo Chaves, David Couper, Neal Freedman, David Jacobs Jr, Miranda Jones, Ravi Kalhan, Amanda Mathew, Richard Kronmal, Laura Loehr, Stephanie London, Anne Newman, George O’Connor, Joseph Schwartz, Benjamin Smith, Lewis Smith, Wendy White, Sachin Yende and Elizabeth Oelsner

Presentation abstract

Background

The number of current smokers has reached its lowest level to date in the US but the proportion of smokers smoking <10 cigarettes per day (CPD) has increased from 16% to 27%, and many consider ‘light’ smoking to be low risk.

Aim

To assess relative risks of respiratory and lung cancer mortality in low-intensity smokers. 

Methods

Data from four US general population cohorts were harmonised and pooled. Current smokers were categorised by self-reported CPD (<10, 10-20, 20+). Adjudication/administrative criteria were used to classify respiratory and lung cancer deaths. Associations were tested via competing risk regression adjusted for sociodemographic factors. 

Results

Of 18,730 participants (mean age 61 yrs, 56% women, 69% white, 13% current smokers, 17 yrs median follow-up), 649 (IDR=20/10,000 person-years) died from respiratory causes while 560 (IDR=17) died from lung cancer.

Compared to never smokers, those with <10CPD had higher risk of respiratory (HR=2.5,P=0.005) and lung cancer (HR=8.6,P=<.0001) mortality. The risks of respiratory and lung cancer mortality associated with <10CPD smoking were 49% and 71%, of the risks of 20+CPD smoking. Results were slightly attenuated after adjusting for smoking duration. 

Conclusions

Risk of respiratory and lung cancer deaths among low-intensity current smokers vs never smokers, is non-trivial: in this study, this risk was equivalent to at least half that seen in those with 20+CPD.

 

‘Social smokers’ face disproportionately high risk of death from lung disease and lung cancer

 

Association of low-intensity smoking with respiratory and lung cancer mortality

 

European Respiratory Congress International Congress 2020, 7-9 September 2020

 


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