-->

Vitamin D deficiency and poor muscle function in the over 60s

Organisation: Position: Deadline Date: Location:

Research from Trinity College Dublin shows that vitamin D deficiency is an important determinant of poor skeletal muscle function in adults aged 60 years and over. Maintaining skeletal muscle function throughout life is a crucial component of successful ageing, in promoting independence, mobility, quality of life and reducing falls and frailty. While resistance exercise is known to preserve muscle function, there is growing evidence that adequate vitamin D status may also be protective.

Key Findings:
The prevalence of muscle weakness was twice as high among older adults with vitamin D deficiency (40.4%) compared with vitamin D adequacy (21.6%).
Similarly, impaired ‘muscle performance’ was 3 times higher in older adults with vitamin D deficiency (25.2%) compared with vitamin D adequacy (7.9%).

Based on more complex statistical analysis, the study showed that vitamin D deficiency significantly increased the likelihood of impaired muscle strength and performance.
The study confirmed the associated benefits of physical activity. Older adults partaking in regular moderate physical activity had significantly lower likelihood of poor muscle strength and physical performance.

In summary, vitamin D deficiency was associated with impaired muscle strength and performance in a large study of community-dwelling older people.
It is generally accepted that vitamin D deficiency (at the 25(OH)D <30 nmol/L cut-off) should be reversed to prevent bone disease, this strategy may also protect skeletal muscle function in ageing.

The findings are based on the analysis of data from 4157 community-dwelling adults aged 60 years and over, from the English Longitudinal Study of Aging (ELSA). Two validated measures of muscle function were assessed, namely hand grip strength and the Short Physical Performance Battery (SPPB). Serum vitamin D was measured [25-hydroxyvitamin D] with a concentration <30 nmol/L classed as vitamin D deficient, the cut-off known to be associated with bone disease.

Maria O’Sullivan, associate professor in nutrition at Trinity College Dublin said: “Our results show that vitamin D deficiency increased the likelihood of poor muscle function in older adults and confirms the protective effect of physical activity. Maintaining muscle function is incredibly important, and often overlooked, in promoting healthy ageing. Addressing this through multimodal approaches that incorporate physical activity, reversing vitamin D deficiency and other modifiable diet and lifestyle components require further investigation.”

Dr Niamh Aspell, first author of the study said: “Overall our findings add weight to the evidence in favour of public health strategies to eliminate vitamin D deficiency in older populations. Future research, however, should identify and focus on older adults with vitamin D deficiency and aim to better understand if reversing this deficiency improves skeletal muscle function.”

Dr Eamon Laird, co-author and Trinity research fellow added that “Vitamin D deficiency and physical activity are modifiable factors. Some countries, for example Finland, have successful implemented a vitamin D food fortification policy which has all but eliminated deficiency in the population. Such a policy could similarly be implemented in the UK and Ireland for older populations.”

Abstract
Purpose: Maintaining skeletal muscle function throughout life is a crucial component of successful ageing. Adequate vitamin D status may be important in preserving muscle function. We aimed to determine the association between impaired muscle function and serum vitamin D status in community-dwelling older adults. Falls were explored as a secondary aim.
Methods: Data were analyzed from adults aged ≥60 years, from Wave 6 of the English Longitudinal Study of Aging (ELSA). Handgrip strength (HGS) and the short physical performance battery (SPPB) were employed as measures of muscle strength and physical function, respectively. Serum 25-hydroxyvitamin D [25(OH)D] was assessed with concentration <30 nmol/L classed as vitamin D deficient.

Results: The study comprised 4157 community-dwelling adults with a mean age of 69.8 (SD 6.9). Overall, 30.6% had low HGS and 12.7% had low SPPB (≤6). Participants with the lowest serum 25(OH)D (<30 nmol/L) had the highest prevalence of impaired muscle strength and performance (40.4% and 25.2%) compared with participants with levels ≥50 nmol/L (21.6% and 7.9%). Consistent with this, vitamin D deficiency (<30 nmol/L) was a significant determinant of low HGS (OR 1.44 [1.22, 1.71], p<0.001) and poor physical performance (OR 1.65 [1.31, 2.09], p<0.001) in the logistic regression models. Older adults partaking in regular moderate physical activity had significantly lower odds of impaired muscle strength (OR 0.65 [0.58, 0.79]) and physical function (OR 0.30 [0.24, 0.38]), p <0.001, respectively. Single or multiple falls (15.8% and 10.5% in past year) were not associated with vitamin D status.
Conclusion: Vitamin D deficiency was associated with impaired muscle strength and performance in a large study of community-dwelling older people. It is generally accepted that vitamin D deficiency at the <30 nmol/L cut-off should be reversed to prevent bone disease, a strategy that may also protect skeletal muscle function in ageing.

Authors
Niamh Aspell, Eamon Laird, Martin Healy, Brian Lawlor, Maria O’Sullivan

Trinity College Dublin material Clinical Interventions in Ageing abstract

Receive Medical Brief's free weekly e-newsletter



Related Posts

Thank you for subscribing to MedicalBrief


MedicalBrief is Africa’s premier medical news and research weekly newsletter. MedicalBrief is published every Thursday and delivered free of charge by email to over 33 000 health professionals.

Please consider completing the form below. The information you supply is optional and will only be used to compile a demographic profile of our subscribers. Your personal details will never be shared with a third party.


Thank you for taking the time to complete the form.