Medical experts say evidence is mounting that as with COVID-19, people can have active TB disease and be infectious without symptoms, and that more than half of those diagnosed with TB in South Africa’s first National TB Prevalence Survey would have been missed had asymptomatic people not been offered additional tests as part of the survey.
TB diagnosis usually starts with asking someone whether they have any of the classic symptoms of TB (coughing, fever, loss of weight and drenching night sweats in adults). Traditionally, only people who have one or more of these symptoms are offered confirmatory molecular tests, writes Tiyese Jeranji for Spotlight.
However, last year, a cluster randomised study found such a targeted universal testing (TUT) approach increased TB detection by 17%. Since then, TUT has been embraced by the National Department of Health and is being rolled out in some districts: early signs are that it is working well.
Another approach is using digital X-ray technology to screen for TB – classified as screening since an X-ray suggestive of TB must be followed by a molecular test to confirm the diagnosis. Here too there is compelling evidence. Of the 234 people diagnosed with TB in the prevalence survey, around 58% had abnormal X-rays without any TB symptoms. The World Health Organisation (WHO) endorses digital X-ray screening for TB and there is also compelling evidence that computers are now as good as humans at interpreting X-ray images.
Boosting TB detection in the real world
Last year Spotlight reported that digital X-ray pilot projects were to be conducted in six of South Africa’s 52 districts. The pilots are co-ordinated by the National Department of Health, supported by the Global Fund to Fight Aids, Tuberculosis and Malaria and the United States Agency for International Development (USAID). These donors have contracted several non-profit organisations to run the pilots in the six districts. In April, it was reported that early signs from the pilots were promising.
An independent assessment of the pilots has now been completed and was presented at the recent South African TB Conference in Durban. A written report has not yet been made public.
Dr Lucy Connell, TB programme head at Right to Care (an NGO), conducted the independent assessment of the Global Fund-supported parts of the pilot. She says that in each of the six districts with clinic-based digital chest X-ray (DCXR) containers, case finding has dramatically increased since 2019 – three-fold in some instances. “Early results show that augmenting TB symptom screening with DCXR screening helps to detect more people with TB,” she says.
In the first phase of the project (1 September 2020 to 30 June 2022) 114 126 people visited the DCXR containers for TB screening (symptom screening followed by X-ray screening): 96% of them were screened with DCXR.
“In the first phase, 15 semi-movable containers equipped with DCXR machines were placed at 24 high-volume clinics in six districts across South Africa,” she says. Cape Town had three containers, Ehlanzeni two, Ekurhuleni two, eThekwini two, Johannesburg three, and the OR Tambo area three.
“These districts were selected because all of them had very large gaps between the number of people estimated to be living with TB and the number being diagnosed and treated,” Connell says.
In clinics in the OR Tambo district that hosted DCXR units, the number of people testing positive for TB went from two out of every 1 000 clinic visitors in 2019 (before DCXR TB screening) to six out of every 1 000 patients when DCXR augmented TB symptom screening took place. This occurred even though the capacity of the DCXR units in their current form is limited to 80 people a day, far short of the number of clinic attendees.
Similarly, in the Ehlanzeni district, one out of every 1 000 clinic visitors was diagnosed in 2019, and more than three times that when the clinics also provided DCXR TB screening. These are, however, correlations and other factors besides X-ray screening that may also have contributed to the increase.
Connell is upbeat about the role of DCXR and its diagnostic accuracy.
“(It) is now the WHO-preferred tool for TB screening among groups at high risk for TB and in countries with the resources to do this,” she says. “Furthermore, the new guidelines recommend the use of computer-aided detection (CAD) for the interpretation of X-rays.
“In addition to detecting more TB among symptomatic patients, DCXR TB screening has also detected TB in asymptomatic people: 28% of all people diagnosed with TB in this phase of the project were asymptomatic and would have been missed if the clinic were relying on symptom screening alone.”
DCXR TB screening alone would find more people with TB than TB symptom screening alone, and the use of DCXR alone finds 84% of all cases diagnosed with both screening methods combined.
“The return on investment on the DCXR lies in not only reducing the prevalence of TB but significantly reducing the costs incurred by families if one of them has TB,” she says. “It impoverishes families.”
Where X-rays fit in
Professor Salome Charalambous, group chief scientific officer at the Aurum Institute (an NGO), questions what additional benefit X-ray screening can offer in places where TUT is already being provided, for instance some correctional facilities.
“We are not sure in this scenario whether there would be an advantage to adding DCXR, since all high-risk individuals will already be tested. The biggest issue is the quite substantial capital outlay to be able to deliver DCXR in prisons,” she says.
“X-ray equipment would need to be bought for each facility or a mobile unit that moves from facility to facility: there would need to be about nine to 10 such units. As far as I know, they have not been routinely implemented. As the technology becomes easier to use and cheaper, it may become more feasible for them to be used routinely in prisons.”
While Charalambous describes the technology as useful, she questions how to use the technology most effectively.
“How to best use the few machines that we have in-country belonging to the Department of Health is the problem. We also need to work with the regulators to reduce the restrictions currently in place regarding X-ray to make it easier and more feasible to implement. X-rays offer a great opportunity to increase diagnosis but we still don’t know how best to utilise them.”
They are working with the government to see if they can quantify, in clinics, how much they can increase diagnosis to see if the costs would be justified. “We are also looking at a strategy to see how digital X-rays can be used to find TB in communities as we know TB affects men disproportionately and they do not generally visit health facilities. So we need to find strategies to identify men with TB.”
Most X-ray screening so far in South Africa has been clinic-based.
Low sputum collection rate
One weakness highlighted in the independent assessment was a very low sputum collection rate. Connell says only a third of all people eligible for a laboratory TB test had a sputum sample submitted. These are needed for the standard molecular TB test to confirm a diagnosis after an X-ray suggestive of TB.
“Of all people eligible for TB testing, the sputum collection rate was highest (67%) for those screening positive on both symptom screen and DCXR screen, lower for those with no TB symptoms but with chest X-ray changes suggestive of TB, and lowest for those with a positive symptom screen but a normal chest X-ray,” she says.
The low sputum collection rate results in the non-detection of people with TB, and undermines the evaluation of the true impact of DCXR screening. “This finding clearly shows that a new technology that has promise is only as good as the performance at every other step of the diagnostic cascade.
“More effort is needed to ensure everyone with with presumed TB is assisted to produce a sputum sample for testing, or the investment in such technology won’t bear fruit. This can be done with dedicated sputum collection staff with access to multiple nebulisers that they can use to help patients secrete and cough up mucus from the lungs,” says Connell.
She adds that there is also a need to continue research to find alternative specimens for TB testing that are easier to collect, like tongue swabs.
Phase two
The second phase of the project to pilot DCXR for TB screening is currently under way. Apart from the DCXR containers in clinics, a fleet of seven mobile vans is now travelling daily to different community locations, says Connell. “Another 15 DCXR vans will be active by the end of 2022. This phase is supported by GIS mapping, to identify ‘TB hotspots’ – areas with high numbers of people being diagnosed with TB and areas with many structural drivers for TB transmission. Mobile vans are placed in high-traffic areas in these hotspots where all people are invited for screening through community mobilisation and information dissemination.”
She says the capacity to use DCXR for community TB screening is critical because the SA National TB Prevalence Survey tells us that 60% of all people with classic TB symptoms had not attended a clinic seeking care for their symptoms.
Government has already incorporated new screening and laboratory testing approaches into the TB Recovery Plan, and into the recently released TB screening and testing Standard Operating Procedure (SOP).
“For example, a major change is that this SOP recommends certain groups of people with a higher risk for TB should be tested routinely at regular intervals, irrespective of symptoms. Those who have been treated and completed TB treatment in the past two years, irrespective of symptoms, must be tested annually for two years, and each time they report TB symptoms on symptom screening.
"People living with HIV must be tested annually, and each time they report TB symptoms; people who have been in close contact with a person diagnosed with TB or TB treatment in the past year irrespective of TB symptoms, and at each new contact thereafter,” says Connell.
See more from MedicalBrief archives:
SA to expedite TB diagnosis/treatment as cases continue to soar
Shorter, simpler DR-TB regimen in the pipeline for South Africa
More than half of South Africans do not seek TB treatment – HSRC survey
Encouraging results from South African TB vaccination trial
New TB screening methods cut deaths in people with HIV