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HomeA Practitioner's Must ReadUrgent need for more funds to fight AMR drug resistance

Urgent need for more funds to fight AMR drug resistance

Common germs are outsmarting medicine much faster than South Africa’s health system can keep up with, and research suggests there isn’t the money (or enough specialists) at state facilities to stop more bugs from becoming untreatable.

Writing for Bhekisisa, Zano Kunene and Linda Pretorius report that a paper published in Antibiotics in June showed only three of 57 health facilities in KwaZulu-Natal have set aside money for teams to roll out South Africa’s official plan for curbing antimicrobial resistance (AMR).

Just four out of 10 hospitals in the province had a microbiologist on their team and only two had an on-site infectious diseases specialist.

The country’s guidelines for dealing with AMR say microbiologists and infectious diseases specialists are crucial on such teams because they help to detect signs of resistant infections early, prevent them from spreading and monitor how antibiotics are prescribed.

AMR develops because, over time, germs change how their cells work to evade things that could kill them. This is a natural process, and generally it would take a very long time for microorganisms sporting a change that could make them resistant to a treatment to become commonplace.

But germs multiply fast. And because we overuse and misuse antibiotics – for example, by taking them when we don’t need them, not finishing the course or having the wrong type of antibiotic prescribed for a certain infection – we allow more and more of the germs that have developed resistance to thrive.

Disease-causing microorganisms like bacteria and fungi that can dodge antibiotics are especially worrisome in hospital-associated infections (HAIs), which develop in seven out of every 100 patients in high-income countries, says the World Health Organisation (WHO). In developing countries it’s double that, they say.

HAIs can easily develop after surgery or in patients on ventilators or on intravenous drips. If the infection is caused by resistant bacteria, an operation such as a knee replacement could mean losing a leg instead.

“A depressing situation”

For some patients, this nightmare scenario has already become a reality. Over the past year, Marc Mendelson, head of South Africa’s ministerial advisory committee on AMR, says four patients in the Western Cape’s Groote Schuur hospital had to have a leg amputated after a common knee operation because of an infection for which antibiotics no longer worked.

Six types of bacteria commonly seen in HAIs are on the WHO’s list of microbes for which new treatments are urgently needed because they’re fast becoming resistant to currently available antibiotics.

The reality of AMR – and the health system’s lukewarm action – presents a depressing situation, says Mendelson.

Time’s running out for the government to achieve its first set of goals to control drug resistance (they lapse in 2024), because its plan has never had enough funding, Mendelson says. And with the national health budget set to decrease in the next couple of years, the situation is unlikely to change.

One place where the loss of working antibiotics will have a big impact is in surgery.

Mendelson says: “Doctors usually give patients an antibiotic shortly before an operation to stop infection in the wound. If the drugs no longer work against common germs, (about) 40% of hip replacements will become infected.”

This means people could choose not to have surgery they need or which could improve their quality of life, such as a hip replacement, he warns.

The bacteria health authorities are most concerned about, especially in hospitals, are commonly called the ESKAPE group, an acronym made up of the individual species’ names.

One is called Klebsiella pneumoniae (the K in ESKAPE), which can lead to bloodstream infections, septic wounds or the patient’s body rejecting a prosthesis like a replacement hip.

There are four types of antibiotics that can be used against this bacterium.

In 2016, about two-thirds of these infections could be eliminated with one of these antibiotics; by 2020 less than half could be treated with this drug.

But by this time about seven out of 10 blood samples showed that “K” had already moved on, and could thwart another medicine too.

We are now down to our last two options, says Mendelson, but a quarter of infections are already resistant to one of them. This leaves us with only one more, called colistin, as our last resort.

The WHO lists this drug as one that should be used only when all other antibiotics no longer work, but special permission is needed to prescribe it in South Africa.“ They [K. pneumoniae] are really pushing the last resort,” said Mendelson. “We’ve had strains in people for which we had no antibiotics left to treat them with.”

How to beat the bugs

Developing new treatments for microbial infections, or preventive medicines such as vaccines, is expensive and takes time, so meanwhile we must make the most of what we have for as long as possible.

One way is to set up an antimicrobial stewardship programme at hospitals. This means putting together a team of health workers comprising doctors, nurses and pharmacists, and led by a microbiologist or infectious diseases specialist, to oversee responsible use of antibiotics.

As part of their oversight, the team would check that the right type of antibiotics is prescribed for patients, the correct dose administered, and that the medicine is given only when laboratory tests confirm it should be.

Having a microbiologist or infectious diseases specialist on the team is important, because of their knowledge of how germs respond to specific antibiotics.

A 2017 study from Groote Schuur Hospital showed that an antimicrobial stewardship programme led by someone with this expertise reduced antibiotic use, for four years running, by almost 20% compared with what it was before. This cut the hospital’s bill for buying these medicines by more than R3m.

But South Africa has far too few of these specialist scientists working in hospitals – only 42, according to Mendelson, and in four of the nine provinces there aren’t any at all.

Not having enough training about antimicrobial stewardship programmes could lead to health workers feeling unsure about prescribing antibiotic treatments, resulting in incorrect prescribing, as a 2018 study across eight primary healthcare facilities in Cape Town showed.

Researchers found that in three out of 10 cases, antibiotics were prescribed without a documented diagnosis to support this treatment, and one out of five patients given antibiotics didn’t need them. The research also revealed that the wrong type of drug was often prescribed, or that doctors advised an incorrect dose or duration of the treatment.

Changing this comes down to money, expertise and awareness – and these three legs can’t stand alone.

Despite “some successes” in getting South Africans, both medical professionals and the public, to use antibiotics more responsibly, such as a ministerial advisory committee being set up and having guidelines for implementing stewardship programmes at facilities, things need to change at a practical level.

Said Mendelson: “It’s human resources, education, and acceptance by the country that will help us limit the rise of untreatable bacterial infections.”

With adequate funding, health workers likes nurses can be trained to become important links between pharmacists, doctors and patients, which a 2022 study showed can lead to significant improvements in responsible antibiotic use.

Financial support for training and employing more infectious diseases specialists can also get these skills into provinces that don’t have access to such expertise.

Until then, outreach activities by specialists at tertiary hospitals can provide remote support to secondary and primary hospitals in rural areas.

Getting pharmacists to do ward rounds in hospitals has also been found to work. In a five-year study across 47 private hospitals in South Africa, pharmacists were involved in checking antibiotic prescriptions. For those that had to be changed, four in 10 were because the treatment was given for too long, and so, by suggesting a change, the pharmacists’ input led to a significant drop in antibiotic use.

Big programmes like this aren’t always possible, and it might not be necessary in each case. Even small steps with limited medical staff representation can make a difference, says Sarentha Chetty, lecturer in pharmacology at the University of the Witwatersrand and lead author in the KZN study.

“Sometimes it’s just one person (with stewardship training) who’s checking things. With the rest of the team’s support it’s doable, even if it’s on a smaller scale.”

Study details

Antimicrobial Stewardship in Public-Sector Hospitals in KwaZulu-Natal, South Africa

Sarentha Chetty, Millidhashni Reddy, Yogandree Ramsamy, Vusi Dlamini, Rahendhree Reddy-Naidoo and Sabiha Essack.

Published in Antiobiotics on 30 June 2022

Abstract
Antimicrobial resistance (AMR) is a serious global public-health threat. Evidence suggests that antimicrobial stewardship (AMS) is a valuable tool to facilitate rational antibiotic use within healthcare facilities. A cross-sectional situational analysis using a questionnaire was conducted to determine the current status of antimicrobial stewardship (AMS) activities in all public-sector hospitals in KwaZulu-Natal (KZN). The survey had a 79% (57, N = 72) response rate. A total of 75% of hospitals had an antimicrobial stewardship committee (AMSC), 47% (20, N = 43) had a formal written statement of support from leadership, and 7% (3, N = 43) had budgeted financial support. Only 37% (16, N = 43) had on-site or off-site support from a clinical microbiologist, and 5% (2, N = 43) had an on-site infectious disease (ID) physician. Microbiologist input on pathogen surveillance data (aOR: 5.12; 95% CI: 4.08–22.02; p-value = 0.001) and microbiological investigations prior to the commencement of antibiotics (aOR: 5.12; 95% CI: 1.08–42.01; p-value = 0.041) were significantly associated with having either on- or off-site microbiology support. Respondents that had a representative from microbiology on the AMSC were significantly associated with having and interrogating facility-specific antibiograms (P = 0.051 and P = 0.036, respectively). Those facilities that had access to a microbiologist were significantly associated with producing an antibiogram (aOR: 4.80; 95% CI: 1.25–18.42; p-value = 0.022). Facilities with an ID physician were significantly associated with having a current antibiogram distributed to prescribers within the facility (P = 0.010) and significantly associated with sending prescribers personalised communication regarding improving prescribing (P = 0.044). Common challenges reported by the facilities included suboptimal hospital management support; a lack of clinicians, pharmacists, nurses, microbiologists, and dedicated time; the lack of a multidisciplinary approach; low clinician buy-in; inadequate training; a lack of printed antibiotic guidelines; and financial restrictions for microbiological investigations. The survey identified the need for financial, IT, and management support. Microbiology and infectious disease physicians were recognised as scarce human resources.

 

Antibiotics article – Antimicrobial Stewardship in Public-Sector Hospitals in KwaZulu-Natal, South Africa (Open access)

 

Bhekisisa article – Superbugs could cost you an arm or a leg: Why hospitals need more money to fight drug resistance (Open access)

 

See more from MedicalBrief archives:

 

Stories from the frontlines of antimicrobial resistance during COVID-19

 

UK’s 5-year action plan to fight super-bug threat

 

Fresh strategies needed to rein in excessive antibiotic use

 

 

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