Anxiety, depression and suicide risk linked to air pollution — first meta-analysis

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The first systematic review and meta-analysis of evidence connecting air pollution reviewed study data from 16 countries and found support for the hypothesis of an association between long-term pollutant exposure and depression and anxiety, as well as between short-term exposure and suicide.

The researchers at University College London (UCL) found that, if the relationship with depression reported in some of these studies is causal, then reducing global average exposure to fine particulate matter (PM2.5) air pollution from 44 micrograms per metre cubed (µg/m3)* to 25µg/m3 could result in a 15% reduction in depression risk worldwide.

The World Health Organisation guidelines recommend that fine particulate matter pollution – small airborne particles that can include dust and soot – should be kept under 10µg/m3.** “We already know that air pollution is bad for people’s health, with numerous physical health risks ranging from heart and lung disease to stroke and a higher risk of dementia,” said the study’s lead author, Dr Isobel Braithwaite (UCL Psychiatry and UCL Institute of Health Informatics).

“Here, we’re showing that air pollution could be causing substantial harm to our mental health as well, making the case for cleaning up the air we breathe even more urgent.”

The research team searched for studies that had investigated the association between particulate matter pollution and five different adverse mental health outcomes in adults. They identified 25 studies that fitted their criteria, nine of which were included in the primary analyses.

Five studies looking at long-term particulate matter exposure and depression were included in one meta-analysis. By pooling the results, they found that a 10µg/m3 (microgram per metre cubed) increase in the average level of fine particulate matter (PM2.5) air pollution people were exposed to over long periods was associated with an approximately 10% increase in their odds of depression.

“We found quite consistent results across the studies we reviewed that analysed the relationship between long-term air pollution exposure and depression, even after adjustment for many other factors which could explain the association. The association seems to be similar in magnitude to those that have been found for some physical health impacts of particulate matter, such as all-cause mortality,” Braithwaite said.

Global city PM2.5 levels range from 114 and 97 in Delhi and Dhaka, to 6 in Ottawa and Wellington.* In UK cities, the average particulate matter level that people are exposed to is 12.8µg/m3**. The researchers estimate that lowering average air pollution levels to the WHO recommended limit of 10µg/m3 could reduce urban UK residents’ depression risk by roughly 2.5%.

The researchers also found evidence of a connection between short-term changes in coarse particulate air pollution (PM10)* exposure and the number of suicides, from pooling the results of four different studies in a meta-analysis. The risk of suicide appears to be measurably higher on days when PM10 levels have been high over a three-day period than after less polluted periods.

The studies into short-term changes in suicide risk accounted for confounding factors such as weather changes, and day of the week. The relationship is not affected by other neighbourhood or socioeconomic factors given that the comparisons being made are among the same individuals on days with different pollution levels.

The researchers say the evidence was particularly strong for the suicide risk link, but the effect was smaller than for depression (an increase in suicide risk of 2% for each 10µg/m3 increase in the average coarse particulate pollution level over a three-day period).

The researchers say they cannot yet confirm whether air pollution directly causes mental ill health, but say there is evidence to suggest possible causal mechanisms. “We know that the finest particulates from dirty air can reach the brain via both the bloodstream and the nose, and air pollution has been implicated in increased neuroinflammation, damage to nerve cells and to changes in stress hormone production, which have been linked to poor mental health,” Braithwaite said.

The study’s senior author, Dr Joseph Hayes (UCL Psychiatry and Camden and Islington NHS Foundation Trust), said: “Our findings correspond with other studies that have come out this year, with further evidence in young people and in other mental health conditions. While we cannot yet say that this relationship is causal, the evidence is highly suggestive that air pollution itself increases the risk of adverse mental health outcomes.”

“A lot of what we can do to reduce air pollution can also benefit our mental health in other ways, such as enabling people to cycle or walk rather than drive, and enhancing access to parks, so this adds support to the promotion of active travel and urban green spaces,” he added.

The researchers hope to follow up their study with further research into indoor air pollution and mental health risks.

The study was conducted by researchers at UCL, Camden and Islington NHS Foundation Trust and King’s College London, and supported by North Central Thames NHS Academic Foundation Programme, National Institute for Health Research,iversity College London Hospitals Biomedical Research Centre, Wellcome and the Royal Society.

Background: Particulate air pollution’s physical health effects are well known, but associations between particulate matter (PM) exposure and mental illness have not yet been established. However, there is increasing interest in emerging evidence supporting a possible etiological link.
Objectives: This systematic review aims to provide a comprehensive overview and synthesis of the epidemiological literature to date by investigating quantitative associations between PM and multiple adverse mental health outcomes (depression, anxiety, bipolar disorder, psychosis, or suicide).

Methods: We undertook a systematic review and meta-analysis. We searched Medline, PsycINFO, and EMBASE from January 1974 to September 2017 for English-language human observational studies reporting quantitative associations between exposure to PM <1.0μm<1.0μm in aerodynamic diameter (ultrafine particles) and PM <2.5<2.5 and <10μm<10μm in aerodynamic diameter (PM2.5PM2.5 and PM10PM10, respectively) and the above psychiatric outcomes. We extracted data, appraised study quality using a published quality assessment tool, summarized methodological approaches, and conducted meta-analyses where appropriate. Results: Of 1,826 citations identified, 22 met our overall inclusion criteria, and we included 9 in our primary meta-analyses. In our meta-analysis of associations between long-term (>6 months>6 months) PM2.5PM2.5 exposure and depression (n=5n=5 studies), the pooled odds ratio was 1.102 per 10-μg/m310-μg/m3PM2.5PM2.5 increase (95% CI: 1.023, 1.189; I2=0.00%I2=0.00%). Two of the included studies investigating associations between long-term PM2.5PM2.5 exposure and anxiety also reported statistically significant positive associations, and we found a statistically significant association between short-term PM10PM10 exposure and suicide in meta-analysis at a 0-2 d cumulative exposure lag.
Discussion: Our findings support the hypothesis of an association between long-term PM2.5PM2.5 exposure and depression, as well as supporting hypotheses of possible associations between long-term PM2.5PM2.5 exposure and anxiety and between short-term PM10PM10 exposure and suicide. The limited literature and methodological challenges in this field, including heterogeneous outcome definitions, exposure assessment, and residual confounding, suggest further high-quality studies are warranted to investigate potentially causal associations between air pollution and poor mental health.

Isobel Braithwaite, Shuo Zhang, James B Kirkbride, David PJ Osborn, Joseph F Hayes

University College London

Environmental Health Perspectives abstract

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