Children of mothers who drink relatively more cow's milk during breastfeeding are at reduced risk of developing food allergies, found a robust Swedish study based on biomarkers, published in the journal Nutrients.
The result is based on a survey of more than 500 Swedish women's eating habits and the prevalence of allergies in their children at one year of age.
"We have found that mothers of healthy one-year-olds consumed more cow's milk during breastfeeding than mothers of allergic one-year-olds. Though the association is clear, we do not claim that drinking cow's milk would be a general cure for food allergies." says Mia Stråvik, doctoral student in the Division of Food Science at Chalmers University of Technology, and first author of the study.
There are many factors behind the risk of food allergy, not least genetic predisposition. Yet, as Mia Stråvik explains, "Diet is a factor where parents themselves can have direct influence. It is quite common nowadays for young women to avoid drinking milk, due in part to prevailing trends and concerns, some of which are linked to myths about diet."
She points out that allergy to milk protein is uncommon in adults, so most women can consume milk and dairy products themselves without issue. Lactose intolerance is something completely different, when the body cannot break down milk sugars. And in this case, lactose-free dairy products are tolerated by the body.
According to Professor Ann-Sofie Sandberg, Mia Stråvik's supervisor, one possible explanation may be that the milk in the mother's diet contains substances that stimulate the maturity of the immune system.
"In a child's early development, there is a time window where stimulation of the immune system is necessary for the child to develop tolerance to different foods."
According to something known as the hygiene hypothesis, early contact with various microorganisms can function as something of a kickstart' for a child's immune system, she explains.
"But, with the lower prevalence of microorganisms nowadays in our more hygienic society, substances taken in through the mother's diet can be another way to stimulate the maturity of the immune system."
Mia Stråvik's study is not the first to link cow's milk in a mother's diet to a reduced risk of allergies in children. Previous studies, however, have often been based solely on questionnaire responses, both in terms of eating habits and the presence of allergies. In this study both data and conclusions are significantly more robust.
"In this study, we were able to actually verify the women's reported intake of milk and milk products through biomarkers in her blood and breast milk. The biomarkers are two fatty acids formed in the cow's stomach, which are specific to dairy products," says Mia Stråvik. "Furthermore, all the cases of allergy in children were diagnosed by a doctor specialising in child allergies."
The study is part of a more extensive research project built around a family cohort study of 655 families who gave birth at Sunderby Hospital near Luleå, northern Sweden, during the years 2015 — 2018. The project was initiated, and the cohort established, by Ann-Sofie Sandberg from Chalmers, Professor Agnes Wold at the University of Gothenburg and the chief physician and paediatric allergist Anna Sandin, affiliated with Umeå University and Sunderby Hospital.
The current study is the first scientific publication, focusing mainly on allergies based on data collected from the families in northern Sweden.
The mothers in the study, more than 500, gave detailed accounts of their eating habits on three occasions — in the 34th week of the pregnancy, one month after the birth and four months after birth. At one year of age, the children were medically examined, and all cases of food allergy, atopic eczema and asthma were identified.
After the material was adjusted for various other factors, such as hereditary predisposition or reverse causation, the researchers were able to establish that there was indeed a clear connection between the mother's intake of milk and dairy products and the smaller incidence of food allergy in their children.
"No matter how we looked at and interpreted the data, we came to the same conclusion," states Chalmers researcher and co-author Malin Barman, Assistant Supervisor to Mia Stråvik."The mechanisms behind why milk has this preventative effect against allergies, however, are still unclear." A further explanation of various hypotheses can be found below.
Another result in the study that Mia Stråvik highlights is that children of breastfeeding mothers, who at the four month measurement were eating a lot of fruit and berries, tended to suffer from eczema to a much greater extent — though she stresses that further studies are needed before anything can be said with certainty about this connection.
A follow-up study is currently underway to examine the children's health at the age of four.
Allergy is the most common chronic disease that affects children, and is becoming ever more prevalent in Sweden and other industrialised countries.
Of the 508 children included in the current study:
7.7 percent of the children (39) had a diagnosed food allergy at one year of age, most commonly to cow's milk or eggs (or both)
6.5 percent of the children (33) were diagnosed with atopic eczema and the same amount were diagnosed with asthma
23 percent of the children had allergies of some type (including non-food-based) at the age of one year
How does milk cause these effects?
It is unclear exactly why cow's milk in the mother's diet can reduce the risk of child allergy. According to researcher Malin Barman, there are several possible explanations, that could potentially work together.
"One hypothesis is that cow's milk contains something that activates the child's immune system and helps it to develop tolerance. This as-yet unknown cause could be found in the fat of the milk or in its protein content. But it could also be the case that the milk itself is neutral in relation to the immune system. Then it might be more simply a matter of a higher intake of milk fats leading to a relatively lower intake of polyunsaturated fats. This would help, because we believe high levels of polyunsaturated fat in a mother's diet can counteract the maturation of a child's immune system at an early age."
Study details
Maternal Intake of Cow’s Milk during Lactation Is Associated with Lower Prevalence of Food Allergy in Offspring. Nutrients
Mia Stråvik, Malin Barman, Bill Hesselmar, Anna Sandin, Agnes E. Wold, Ann-Sofie Sandberg.
Abstract
Maternal diet during pregnancy and lactation may affect the propensity of the child to develop an allergy. The aim was to assess and compare the dietary intake of pregnant and lactating women, validate it with biomarkers, and to relate these data to physician-diagnosed allergy in the offspring at 12 months of age. Maternal diet during pregnancy and lactation was assessed by repeated semi-quantitative food frequency questionnaires in a prospective Swedish birth cohort (n = 508). Fatty acid proportions were measured in maternal breast milk and erythrocytes. Allergy was diagnosed at 12 months of age by a paediatrician specialized in allergy. An increased maternal intake of cow’s milk during lactation, confirmed with biomarkers (fatty acids C15:0 and C17:0) in the maternal blood and breast milk, was associated with a lower prevalence of physician-diagnosed food allergy by 12 months of age. Intake of fruit and berries during lactation was associated with a higher prevalence of atopic eczema at 12 months of age. Our results suggest that maternal diet modulates the infant’s immune system, thereby influencing subsequent allergy development.
[link url="https://www.mdpi.com/2072-6643/12/12/3680/htm"]Full study in Nutrition (Open access)[/link]
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