General cognitive ability in youth predicts mental capacity later in life

Organisation: Position: Deadline Date: Location:

Early adult general cognitive ability (GCA) – the diverse set of skills involved in thinking, such as reasoning, memory and perception – is stronger predictor of cognitive function and reserve later in life than other factors, such as higher education, occupational complexity or engaging in late-life intellectual activities, report researchers.

Higher education and late-life intellectual activities, such as doing puzzles, reading or socialising, have all been associated with reduced risk of dementia and sustained or improved cognitive reserve. Cognitive reserve is the brain’s ability to improvise and find alternate ways of getting a job done and may help people compensate for other changes associated with ageing.

An international team of scientists, led by scientists at University of California San Diego School of Medicine, sought to address a “chicken or egg” conundrum posed by these associations. Does being in a more complex job help maintain cognitive abilities, for example, or do people with greater cognitive abilities tend to be in more complex occupations?

The researchers evaluated more than 1,000 men participating in the Vietnam Era Twin Study of Aging. Although all were veterans, nearly 80% of the participants reported no combat experience. All of the men, now in their mid-50s to mid-60s, took the Armed Forces Qualification Test at an average age of 20. The test is a measure GCA. As part of the study, researchers assessed participants’ performance in late midlife, using the same GCA measure, plus assessments in seven cognitive domains, such as memory, abstract reasoning and verbal fluency.

They found that GCA at age 20 accounted for 40% of the variance in the same measure at age 62, and approximately 10 percent of the variance in each of the seven cognitive domains. After accounting for GCA at age 20, the authors concluded, other factors had little effect. For example, lifetime education, complexity of job and engagement in intellectual activities each accounted for less than 1% of variance at average age 62.

“The findings suggest that the impact of education, occupational complexity and engagement in cognitive activities on later life cognitive function likely reflects reverse causation,” said first author Dr William S Kremen, professor in the department of psychiatry at UC San Diego School of Medicine. “In other words, they are largely downstream effects of young adult intellectual capacity.”

In support of that idea, researchers found that age 20 GCA, but not education, correlated with the surface area of the cerebral cortex at age 62. The cerebral cortex is the thin, outer region of the brain (grey matter) responsible for thinking, perceiving, producing and understanding language.

The authors emphasised that education is clearly of great value and can enhance a person’s overall cognitive ability and life outcomes. Comparing their findings with other research, they speculated that the role of education in increasing GCA takes place primarily during childhood and adolescence when there is still substantial brain development.

However, they said that by early adulthood, education’s effect on GCA appears to level off, though it continues to produce other beneficial effects, such as broadening knowledge and expertise.

Kremen said remaining cognitively active in later life is beneficial, but “our findings suggest we should look at this from a lifespan perspective. Enhancing cognitive reserve and reducing later life cognitive decline may really need to begin with more access to quality childhood and adolescent education.”

The researchers said additional investigations would be needed to fully confirm their inferences, such as a single study with cognitive testing at different times throughout childhood and adolescence.

Abstract
How and when education improves cognitive capacity is an issue of profound societal importance. Education and later-life education-related factors, such as occupational complexity and engagement in cognitive-intellectual activities, are frequently considered indices of cognitive reserve, but whether their effects are truly causal remains unclear. In this study, after accounting for general cognitive ability (GCA) at an average age of 20 y, additional education, occupational complexity, or engagement in cognitive-intellectual activities accounted for little variance in late midlife cognitive functioning in men age 56–66 (n = 1009). Age 20 GCA accounted for 40% of variance in the same measure in late midlife and approximately 10% of variance in each of seven cognitive domains. The other factors each accounted for <1% of the variance in cognitive outcomes. The impact of these other factors likely reflects reverse causation—namely, downstream effects of early adult GCA. Supporting that idea, age 20 GCA, but not education, was associated with late midlife cortical surface area (n = 367). In our view, the most parsimonious explanation of our results, a meta-analysis of the impact of education, and epidemiologic studies of the Flynn effect is that intellectual capacity gains due to education plateau in late adolescence/early adulthood. Longitudinal studies with multiple cognitive assessments before completion of education would be needed to confirm this speculation. If cognitive gains reach an asymptote by early adulthood, then strengthening cognitive reserve and reducing later-life cognitive decline and dementia risk may really begin with improving educational quality and access in childhood and adolescence.

Authors
William S Kremen, Asad Beck, Jeremy A Elman, Daniel E Gustavson, Chandra A Reynolds, Xin M Tu, Mark E Sanderson-Cimino, Matthew S Panizzon, Eero Vuoksimaa, Rosemary Toomey, Christine Fennema-Notestine, Donald J Hagler Jr, Bin Fang, Anders M Dale, Michael J Lyons, and Carol E Franz

University of California – San Diego material
Proceedings of the National Academy of Sciences (PNAS) Journal abstract


Receive Medical Brief's free weekly e-newsletter



Related Posts

Thank you for subscribing to MedicalBrief


MedicalBrief is Africa’s premier medical news and research weekly newsletter. MedicalBrief is published every Thursday and delivered free of charge by email to over 33 000 health professionals.

Please consider completing the form below. The information you supply is optional and will only be used to compile a demographic profile of our subscribers. Your personal details will never be shared with a third party.


Thank you for taking the time to complete the form.