Link between sleep duration and sperm health

Organisation: Position: Deadline Date: Location:

A Chinese study has found a link between sleep duration and a measure of chromosomal health in sperm.

In the study of 2,020 semen samples provided by 796 male volunteers from colleges in Chongqing (China) from 2013 to 2015, volunteers with more than 9 hours per day of sleep and those with 6.5 hours or less per day sleep had 41% and 30% lower High DNA Stainability – an index that represents the proportion of sperm with abnormal chromatin – than did volunteers with 7 to 7.5 hours per day of sleep. Chromatin is a complex of DNA and proteins that forms chromosomes.

“This is new information after our previous finding that sleep duration has an inverse U-shaped association with semen volume and total sperm count. In the previous study, we found that these two semen parameters were highest when sleep is 7.0 to 7.5 hours per day, and either longer or shorter sleep was associated with the decrease of the two semen parameters.,” said Dr Jia Cao, co-author of the study at the Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing, China.

Abstract
This study explores whether sleep duration is associated with sperm chromatin integrity. To do so, we conducted a three-phase panel study of 796 male volunteers from colleges in Chongqing (China) from 2013 to 2015. Sleep duration was measured using a modified Munich Chronotype Questionnaire. Sperm DNA integrity was examined via Sperm Chromatin Structure Assay and Comet assay. Setting 7–7.5 h day−1 of sleep duration as a reference, either longer or shorter sleep duration was associated negatively with high DNA stainability (HDS) (P = 0.009), which reflected the immaturity of sperm chromatin. The volunteers with > 9.0 h day−1 sleep and those with ≤ 6.5 h day−1 sleep had 40.7 and 30.3% lower HDS than did volunteers with 7–7.5 h day−1 sleep. No association was found between sleep duration and DNA fragmentation index or Comet assay parameters. This study suggests that sleep duration is associated with sperm chromatin integrity. Further studies are required to validate these findings and investigate the mechanism underlying this association.

Authors
Xiaogang Wang, Qing Chen, Peng Zou, Taixiu Liu, Min Mo, Huan Yang, Niya Zhou, Lei Sun, Hongqiang Chen, Xi Ling, Kaige Peng, Lin Ao, Huifang Yang, Jia Cao, Zhihong Cui

Wiley material
Journal of Sleep Research abstract


Receive Medical Brief's free weekly e-newsletter



Related Posts

Thank you for subscribing to MedicalBrief


MedicalBrief is Africa’s premier medical news and research weekly newsletter. MedicalBrief is published every Thursday and delivered free of charge by email to over 33 000 health professionals.

Please consider completing the form below. The information you supply is optional and will only be used to compile a demographic profile of our subscribers. Your personal details will never be shared with a third party.


Thank you for taking the time to complete the form.