Low fitness linked with an up to 35% higher psoriasis risk later in life

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A major register-based study among Swedish military conscripts, over a median of 31 years, found an up to 35% elevated risk of the least fit developing psoriasis in later life, writes MedicalBrief.

The University of Gothenburg, Sweden study was based on data on more than 1.2m men conscripted, aged 18, into the Swedish Armed Forces between the years 1968 and 2005. During the enrolment process, all these young men underwent the same fitness test on an exercise bicycle. The researchers divided the data, according to how fit the men were, into three levels (low, medium, and high fitness). They then merged the data with other registers, using Sweden’s National Patient Register to obtain diagnostic codes for psoriasis and the joint disease psoriatic arthritis. The men who had already received one of these diagnoses before conscription were excluded from the study.

Later in life, between the ages of 37 and 51, just over 23,000 of the conscripts developed psoriasis or psoriatic arthritis. In the low-fitness group, 2.5% developed one or both of these diseases, while only 1.7% in the high-fitness group did so. In calculating this risk differential, the scientists adjusted for other risk factors, such as body mass index (BMI).

Thus, the less fit the men were when they were recruited, the higher the proportion of them who later fell ill with psoriasis or psoriatic arthritis. In the low-fitness group, the risk of developing psoriasis was 35% higher, and that of developing psoriatic arthritis 44% higher, than in the high-fitness group.

“We show that there’s an association between lower fitness and raised risk of developing psoriasis and psoriatic arthritis, but we don’t show a causal connection. So, we can’t say that these health conditions can be prevented by exercising,” says the study’s first author Marta Laskowski, a doctoral student in dermatology at the University of Gothenburg and resident physician (specialist trainee) at Sahlgrenska University Hospital.

The group of men who were least fit was also the smallest: just under 48,000 or 3.9% of all the conscripts in the study. This is a group that healthcare services should try to monitor regularly.

“Low fitness was already known to boost the risk of incurring cardiovascular disease, and psoriasis as such is linked to raised cardiovascular disease risk, too. The results from our study confirm the reasons for assessing people’s fitness early in life, to identify individuals at a higher risk for adverse health outcomes later in life,” Laskowski says.

Previous research has indicated that, in general, people with psoriasis are less fit than those without it who engage in an equal amount of physical activity. However, the reasons for this difference have not been fully clarified.

“One weakness of our study is that we weren’t been able to monitor the trends of the men’s fitness during the intervening years, between their conscription and the disease onset. We’re also lacking data on smoking, which is a known risk factor for psoriasis,” Laskowski explains.

Some 300,000 Swedes have psoriasis in a mild, moderate, or severe form. It is a chronic, systemic inflammatory disease that affects women as often as men. What triggers its onset is not entirely clear, but heredity is known to play a large part in combination with external factors. The most common type, plaque psoriasis, causes reddened, flaking, and itchy skin lesions (“plaques”).

Psoriasis sufferers also often have other diseases. Some 30% get the inflammatory joint condition known as psoriatic arthritis. Examples of other known comorbidities are obesity, cardiovascular disease, diabetes, and depression.

In recent years, treatment options have substantially improved. Today, besides ointments with local effects, there are drugs that have systemic effects. Recent years have also seen the emergence of efficacious biological agents that modulate the signalling cascade in the inflammatory process that drives psoriasis.

 

Study details

Cardiorespiratory fitness in late adolescence and long-term risk of psoriasis and psoriatic arthritis among Swedish men

Marta Laskowski, Linus Schiöler, Helena Gustafsson, Ann-Marie Wennberg, Maria Åberg, Kjell Torén

Published in PLOS One 11 January, 2021

Abstract

Background
Psoriasis is a chronic immune-mediated disease and psoriatic arthritis is a common coexisting condition. Cardiorespiratory fitness is the overall capacity to perform exertion exercise. Low levels of cardiorespiratory fitness are associated with negative health outcomes. Individuals with psoriasis have lower cardiorespiratory fitness compared with individuals without psoriasis. There are no previous studies exploring the association between cardiorespiratory fitness and new-onset psoriasis and psoriatic arthritis.

Methods
With the objective to investigate whether low cardiorespiratory fitness in late adolescence increases the risk for onset of psoriasis and psoriatic arthritis, a cohort of Swedish men in compulsory military service between 1968 and 2005 was created using data from the Swedish Military Service Conscription Register. Cardiorespiratory fitness, estimated by maximum capacity cycle ergometer testing at conscription, was divided into three groups: high, medium, and low. Diagnoses were obtained using the Swedish National Patient Register and cohort members were followed from conscription until an event, new-onset psoriasis or psoriatic arthritis, occurred, or at the latest until 31 December 2016. Cox regression models adjusted for confounders at conscription were used to obtain hazard ratios with 95% confidence intervals for incident psoriasis and psoriatic arthritis.

Results
During the follow-up period (median follow-up time 31 years, range 0–48 years), 20,679 cases of incident psoriasis and 6,133 cases of incident psoriatic arthritis were found among 1,228,562 men (mean age at baseline 18.3 years). There was a significant association between low cardiorespiratory fitness and incident psoriasis and psoriatic arthritis (hazard ratio 1.35 (95% confidence interval 1.26–1.44) and 1.44 (95% confidence interval 1.28–1.63), respectively).

Conclusions
These novel findings suggest that low cardiorespiratory fitness at an early age is associated with increased risk of incident psoriasis and psoriatic arthritis among men, and highlight the importance of assessing cardiorespiratory fitness early in life.

 

University of Gothenburg material

 

PLOS One study (Open Access)

 

SEE ALSO FROM THE MEDICALBRIEF ARCHIVES:

Western diet rich in fat and sugar linked to skin inflammation and psoriasis

 

Psoriasis link with type 2 diabetes and obesity

 

Psoriasis patients benefit from bariatric surgery

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