People with COVID-19 have higher risk of dying after cardiac arrest — Swedish study

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COVID-19 patients who suffer a cardiac arrest either in or out of hospital are far more likely to die than patients who are not infected with the coronavirus. In particular, women have the highest risk of dying: they are nine times more likely to die after suffering a cardiac arrest in hospital, according to research.

The study from Sweden included 1,946 people who suffered a cardiac arrest out of hospital (OHCA) and 1,080 who suffered one in hospital (IHCA) between 1 January and 20 July.

During the pandemic phase of the study, COVID-19 was involved in at least 10% of all OHCAs and 16% of IHCAs. Coronavirus patients who had an OHCA had a 3.4-fold increased risk of dying within 30 days, while IHCA patients had a 2.3-fold increased risk of dying within 30 days. None of these patients had been discharged alive from hospital by the time the study was written in October 2020. Many had died and the rest were still being treated in hospital.

The first author of the study, Dr Pedram Sultanian, a doctoral student at the University of Gothenburg (Sweden), said: “Our study clearly shows that cardiac arrest and COVID-19 is a very lethal combination. Patients with the coronavirus should be monitored intensively and measures taken to prevent cardiac arrest, for instance with the use of continuous heart monitors for patients at high risk.”

This is the first detailed report of characteristics and outcomes in COVID-19 patients who suffer cardiac arrest. The researchers analysed data from the Swedish Registry for Cardiopulmonary Resuscitation (SRCR), which is a nationwide registry that started to collect data on COVID-19 from 1 April 2020 onwards. The researchers included all cardiac arrests registered in the SRCR from 1 January to 20 July 2020, and divided them into a pre-pandemic group (before 16 March) and a pandemic group (16 March to 20 July).

They found that 7.6% of pre-pandemic patients were still alive 30 days after suffering an OHCA. Once the pandemic started, 9.8% of patients without COVID-19 and 4.7% with COVID-19 survived for 30 days; 83.4% of COVID-19 patients died within 24 hours. Pre-pandemic, 36.4% of IHCA patients survived for 30 days, but once the pandemic started 39.5% of non-COVID-19 patients and 23.1% of COVID-19 patients survived for 30 days; 60.5% of COVID-19 patients died within 24 hours.

The slightly improved survival for uninfected patients suffering OHCA and IHCA during the pandemic is not statistically significant, but the researchers believe that if there is an actual improvement, it might be explained in part by the 8.2% increase in cardiac arrests witnessed by bystanders and the 47% increase in bystanders using defibrillators.

When they compared pre-pandemic cases with COVID-19 cases, the researchers found that the overall risk of dying following an OHCA nearly tripled; it was increased 4.5-fold for men and by a third for women. The overall risk of dying after an IHCA more than doubled; it was increased by a half in men and more than nine-fold in women.

The researchers also found a 2.7-fold increase in the proportion of OHCAs caused by breathing problems, and an 8.6% increase in compression-only cardiopulmonary resuscitation (CPR) during the pandemic. The percentage of people who were treated with both chest compression as well as mouth-to-mouth resuscitation, fell from 33% pre-pandemic to 23% during the pandemic. In March the European Resuscitation Council and the Swedish Resuscitation Council issued guidelines recommending that bystanders who see a cardiac arrest should avoid mouth-to-mouth resuscitation and concentrate on chest compressions in the case of suspected COVID-19 infection.

Senior author of the study, Dr Araz Rawshani, physician and researcher at the University of Gothenburg, said: “Although previous studies have indicated that compression-only CPR delivered by bystanders may be as effective as compressions and ventilation combined, this may not apply to cases with COVID-19, since they are primarily suffering from respiratory failure. We believe this is an important finding that could possibly help authorities in handling the pandemic. Since COVID-19 transmits through droplets, bystanders should avoid mouth-to-mouth resuscitation in accordance with current recommendations. There is no unanimous answer for how society and healthcare providers should adapt in the light of this issue.”

He added: “The study also shows that fewer patients in hospital with COVID-19 were monitored with electrocardiograms, which is potentially life-saving as it enables a cardiac arrest to be spotted immediately. We believe that COVID-19 patients should be monitored with ECGs and monitored for oxygen saturation, as this would allow for prompt recognition of irregular heartbeats and declining oxygen saturation.”

Limitations of the study include the fact that the county of Stockholm, where the majority of coronavirus cases have occurred, had not reported data on OHCAs at the time of the study and this reduced the number of COVID-19 patients in the study; and some cases of COVID-19 may have been misclassified, particularly for cardiac arrests occurring out of hospital.

 

Study details
Cardiac arrest in COVID-19: characteristics and outcomes of in- and out-of-hospital cardiac arrest. A report from the Swedish Registry for Cardiopulmonary Resuscitation

Pedram Sultanian, Peter Lundgren, Anneli Strömsöe, Solveig Aune, Göran Bergström, Eva Hagberg, Jacob Hollenberg, Jonny Lindqvist, Therese Djärv, Albert Castelheim, Anna Thorén, Fredrik Hessulf, Leif Svensson, Andreas Claesson, Hans Friberg, Per Nordberg, Elmir Omerovic, Annika Rosengren, Johan Herlitz, Araz Rawshani

Published in the European Heart Journal on 5 February 2021

Abstract
Aim
To study the characteristics and outcome among cardiac arrest cases with COVID-19 and differences between the pre-pandemic and the pandemic period in out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA).
Method and results
We included all patients reported to the Swedish Registry for Cardiopulmonary Resuscitation from 1 January to 20 July 2020. We defined 16 March 2020 as the start of the pandemic. We assessed overall and 30-day mortality using Cox regression and logistic regression, respectively. We studied 1946 cases of OHCA and 1080 cases of IHCA during the entire period. During the pandemic, 88 (10.0%) of OHCAs and 72 (16.1%) of IHCAs had ongoing COVID-19. With regards to OHCA during the pandemic, the odds ratio for 30-day mortality in COVID-19-positive cases, compared with COVID-19-negative cases, was 3.40 [95% confidence interval (CI) 1.31–11.64]; the corresponding hazard ratio was 1.45 (95% CI 1.13–1.85). Adjusted 30-day survival was 4.7% for patients with COVID-19, 9.8% for patients without COVID-19, and 7.6% in the pre-pandemic period. With regards to IHCA during the pandemic, the odds ratio for COVID-19-positive cases, compared with COVID-19-negative cases, was 2.27 (95% CI 1.27–4.24); the corresponding hazard ratio was 1.48 (95% CI 1.09–2.01). Adjusted 30-day survival was 23.1% in COVID-19-positive cases, 39.5% in patients without COVID-19, and 36.4% in the pre-pandemic period.
Conclusion
During the pandemic phase, COVID-19 was involved in at least 10% of all OHCAs and 16% of IHCAs, and, among COVID-19 cases, 30-day mortality was increased 3.4-fold in OHCA and 2.3-fold in IHCA.

 

ESC Cardio material

 

European Heart Journal study (Open access)

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