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Intravenous remdesivir reduced hospitalisation by 87% in high-risk COVID patients

A three-day course of intravenous remdesivir reduced the risk of hospitalisation by 87% versus placebo, in COVID-19 outpatients at high risk of progression to...

Vaccination 5x more effective against hospitalisation than prior COVID infection — CDC analysis

A nationwide analysis from the US Centers for Disease Control and Prevention (CDC) shows that mRNA COVID-19 vaccines are associated with significantly more immunity...

Neurological complications after first dose of Pfizer and AstraZeneca vaccines

Increased but low risk of Guillain–Barré syndrome and Bell’s palsy after first dose of the Oxford–AstraZeneca  vaccine, as well as of haemorrhagic stroke after...

Anti-vaccine chiropractors: A rising force of misinformation

An Associated Press investigation has found that in the United States, “a major purveyor” of anti-vaccine activism and misinformation is a small but vocal...

UK reports 30,000 “yellow card” menstrual-related vaccination occurrences

Medical professionals are increasingly being approached by women who have experienced changes to periods and unexpected vaginal bleeding after being vaccinated, writes Dr Victoria...

Healthy boys at greater risk from vaccination than COVID itself — US analysis

Healthy boys may be more likely to be admitted to hospital with post-vaccination myocarditis, a rare side-effect of the Pfizer/BioNTech COVID vaccine, than with...

Acute COVID: 35% higher risk of substantial decline in kidney function

COVID-19 survivors exhibited substantially increased risk of adverse kidney outcomes in the post-acute phase, found an analysis of 1.7m US military veterans’ records, in...

New COVID variant — More mutated, more transmissible, and all over SA

A coronavirus variant first detected in South Africa and since found in England, China, the Democratic Republic of the Congo, Mauritius, New Zealand, Portugal and Switzerland, could be more infectious than other mutations and...

Doctors are ambivalent about the looming catastrophe of ‘long COVID’

The medical community has been ambivalent about recognising “ long COVID” as a legitimate disease or syndrome, partly because it currently has no accepted...

Efficacy and safety of Pfizer-BioNTech vaccine after six months

The Pfizer-BioNTech (BNT162b2) vaccine prevents COVID-19 effectively for up to six months after the second dose across diverse populations, including 100% efficacy against the...

CDC warns: Delta more transmissible than Ebola, as contagious as chickenpox

The Delta variant is more transmissible than Ebola and as infectious as chickenpox, warns the US Centers for Disease Control and Prevention, writes MedicalBrief....

Study supporting Ivermectin for COVID withdrawn over ethical concerns

The efficacy of Ivermectin, the drug being unofficially promoted worldwide for treating COVID-19, is again under challenge after a much cited study suggesting the...

COVID-19 vaccines highly effective in most people in clinical risk groups — Massive UK study

The Pfizer/BioNTech and AstraZeneca/Oxford COVID-19 vaccines are as effective at preventing symptomatic illness in people with underlying medical conditions as in the rest of...

Azithromycin doesn't reduce hospitalisation or mortality risk in mild-to-moderate COVID-19

A randomised clinical trial conducted in the United Kingdom found that use of the antibiotic azithromycin in patients with mild-to-moderate COVID-19 did not reduce...

Long COVID: More than a quarter of patients still symptomatic after six months — Swiss study

In a study of adults from the Zurich general population who were infected with COVID-19 in 2020, more than a quarter report not having...

COVID-19 antibodies persist at least nine months after infection — Assay tests in Italy

Researchers from the University of Padua and Imperial College London tested more than 85% of the 3,000 residents of Vo’, Italy, in February/March 2020...

Delta variant: Not just hyper-contagious but also multiplies more rapidly inside respiratory tract

After months of data collection, scientists agree: the Delta variant is the most contagious version of the coronavirus worldwide. It spreads about 225% faster...

Pfizer and Moderna cut COVID-19 infection risk by 91% in the fully vaccinated

mRNA vaccines were highly effective among working-age adults in preventing SARS-CoV-2 infection when administered in real-world conditions, lessening the viral RNA load, risk of...

Need for full COVID vaccination to protect against Delta — Pasteur Institute

With the welter of news about the Delta variant spreading around the world, one theme has emerged: this form of the virus that causes...

Ivermectin: Studies come thick and fast; Regulators remain unmoved

Three significant studies of Ivermectin in COVID-19  have been released in the past week, with two sets of meta-analyses delivering contradictory results and the...

FDA approves arthritis drug for emergency use in hospitalised COVID patients

The US Food and Drug Administration (FDA) has issued an emergency use authorisation (EUA) for Roche's Actemra, an arthritis medicine, to treat adults and...

Millions of cancelled operations due to COVID and high death risk – UK study

The first nationwide study of the impact of COVID-19 on surgery at NHS hospitals in the United Kingdom has revealed that more than 1.5...

COVID-19, not Pfizer vaccine, tied to Bell’s palsy — 2 studies

The Pfizer/BioNTech vaccine has not been linked with a higher risk for the facial nerve paralysis known as Bell's palsy, but COVID-19 itself does...

Ivermectin significantly reduces COVID-19 mortality risk — FLCC meta-analysis

Ivermectin may reduce mortality risk in mild-to-moderate COVID-19 patients by an average of 62%, according to a meta-analysis in American Journal of Therapeutics. The...

Pfizer mRNA vaccine induces persistent human germinal centre responses

SARS-CoV-2 mRNA-based vaccination of humans induces a persistent GC B cell response, enabling the generation of robust humoral immunity, found  a study in Nature. The...

Long COVID-19 may have affected 2m in England – REACT-2

More than 2 million adults in England probably experienced persistent symptoms of so-called Long Covid, according to the large REACT-2 study, reports MedicalBrief. Researchers from Imperial...

Gauteng’s 3rd wave: 'It’s too late for anything but to just stay at home,’ warn experts

Medical scientists have warned that moves to tighten restrictions as Covid-19 cases threaten to overwhelm Gauteng hospitals are too late to be of use,...

Diabetes drug shows promise for COVID-19 lung inflammation

Researchers have identified the molecular mechanism for the anti-inflammatory activity of diabetes drug metformin, reports the University of California – San Diego. They say...

Saliva can be more effective than nasopharyngeal swabs for COVID-19 testing

The addition of a simple processing step to saliva samples before testing may improve COVID-19 detection rate, eliminate the challenges of nasopharyngeal testing, and...

Many post-COVID patients get new medical problems, US study finds

Hundreds of thousands of people in the United States have sought medical care for post-COVID health problems that they had not been diagnosed with...

Warmer temperatures lessen COVID-19 spread, but controls still needed

Research shows that transmission of the virus behind COVID-19 varies seasonally, but warmer conditions are not enough to prevent transmission. A study led by...

Regeneron treatment cuts COVID-19 mortality by 20% — RECOVERY trial

The world‘s largest trial of COVID-19 therapeutics has provided the first convincing evidence that a therapy that directly attacks the virus can save hospitalised...

Drop in convalescent plasma use in US hospitals linked to higher COVID-19 mortality

A slowdown in the use of convalescent plasma to treat hospitalised COVID-19 patients led to a higher COVID-19 mortality during a critical period during...

Vegetarians and pescatarians less likely to develop severe Covid-19

Vegetarians and pescatarians are up to 73% less likely to develop severe Covid-19 than meat-eaters, a Johns Hopkins study finds. But no association was...

Encouraging safety results from Sisonke trial of J&J vaccine in SA

The Sisonke Phase 3b clinical trial of the Johnson & Johnson COVID-19 vaccine, during which an impressive nearly 290,000 frontline South African health workers...

COVID-19 Wuhan lab escape theory gets a second look

Initially dismissed as conspiracy theory, the possibility that the COVID-19 is the consequence of a Chinese laboratory accident is suddenly getting a second look,...

Low testosterone may link to more sever COVID-19 — Washington University study

Among men, low testosterone levels may to more severe disease, found a Washington University study, reports MedicalBrief. Although the study could not prove low testosterone as a...

India’s COVID crisis – New cases decline but daily deaths top 4,500

New cases of COVID-19 are declining in India but the health system is failing and daily deaths continue rising, writes MedicalBrief. There have been horror...

Pfizer vaccine 'extraordinarily effective' against UK and SA variants — Two studies

The Pfizer-BioNTech coronavirus vaccine is "extraordinarily effective" at protecting against severe disease caused by two dangerous variants, according to two studies, reports The New...

Cutaneous reactions to Moderna and Pfizer vaccination — Registry-based study

While some dermatologic reactions to Moderna and Pfizer vaccines mimicked SARS-CoV-2 infection itself, cutaneous reactions to COVID-19 vaccination are generally minor and self-limited, and...