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No benefit in dexamethasone following hospital discharge – US cohort study

Continuing the corticosteroid dexamethasone after hospital release didn't benefit COVID-19 patients who did not complete the 10-day drug regimen during their stay, according to...

Nearly 90% of COVID patients qualifying for ECMO but nor receiving it, died – Vanderbilt

Nearly 90% of US COVID-19 patients who qualified for, but did not receive, ECMO (extracorporeal membrane oxygenation) due to a shortage of resources during...

ECMO may offer severe COVID patients a return to normal life – NYU one-year followup

Some patients with severe COVID-19, treated with extracorporeal membrane oxygenation (ECMO), may experience significant lung recovery and return to normal lives with “meaningful” long-term...

SARS-CoV-2 related coronaviruses detected in trafficked pangolins in Vietnam

Pangolins confiscated from the illegal wildlife trade in Vietnam harboured coronaviruses related to SARS-CoV-2, something previously detected only in China, reports a study in...

Excess mortality estimates put global COVID deaths at more than 18m

Some 18.2m people have died during the coronavirus pandemic, three times higher than official figures of 5.9m at the end of last year, according...

Congenital heart defects plus COVID-19 increase risk of severe illness and ICU

People with a congenital heart defect, hospitalised with COVID-19 infection, had more risk of severe illness or death than those without a heart defect,...

COVID -19 may cause neurological tissue damage, grey matter loss – Oxford

COVID-19 may cause changes in the brain, including greater loss of grey matter and tissue damage, than naturally occurs in uninfected people, a large...

‘Heartbreaking’: South Africa has more than 134,000 orphans from COVID-19

In what researchers describe as a “heartbreaking hidden pandemic”, up to 6.7m children globally have been orphaned or lost a caregiver due to COVID-19....

WHO 'strongly recommends' baricitinib for ventilated COVID patients

More critically ill COVID-19 patients on a mechanical ventilator or extracorporeal membrane oxygenation (ECMO) survived when randomised to receive baricitinib, compared with those on...

70-year-old disulfiram protects against acute lung injury in COVID – US rodent study

A US Food & Drug Administration (FDA) approved drug that has been in clinical use for more than 70 years may protect against lung...

Vitamin supplementation unlikely to reduce COVID-19 mortality – Toledo meta-analysis

A meta-analysis of 26 studies that included more than 5,600 patients hospitalised with COVID-19 has found that taking immune-boosting micronutrients like vitamin C, vitamin...

Higher COVID-19 mortality in young Africans than European and US counterparts

African children and adolescents hospitalised with COVID-19 experience substantially higher mortality rates than Europeans or North Americans of the same age, according to the...

Antarctic find fuels theory of accidental COVID leak from research lab

The controversial theory that COVID-19 accidentally leaked from a Chinese laboratory was given fresh momentum after scientists studying soil samples in Antarctica stumbled upon...

Strokes in COVID-19 patients associated with higher disability and death risk

Patients with COVID-19 who suffer acute ischaemic stroke (AIS) appear to be at significantly higher risk of severe disability and death compared with stroke...

Booster mRNA vaccines wane in effectiveness at 4 months – CDC

A nationwide study from the US Centers for Disease Control and Prevention (CDC) is the first to show that immunity against severe COVID-19 disease...

Extensive placental damage in some unvaccinated women causes stillbirths

In unvaccinated mothers with COVID-19, the placentas had a severe abnormality called SARS-CoV-2 placentitis, which killed the placental tissue and resulted in stillbirths or...

Natural immunity offers ‘robust protection’ in severe Omicron – Qatar study

The effectiveness of previous COVID-19 infection in preventing reinfection was estimated at 56% against the Omicron variant, compared with 90% against the Alpha variant,...

A summation of what is known about Omicron’s BA.2 variant

Omicron BA.2 is inherently substantially more transmissible than BA, and  possesses immune-evasive properties but does not increase its transmissibility from vaccinated individuals with breakthrough...

Reverse zoonoses in COVID-infected lions and pumas at Gauteng zoo

Reverse zoonotic COVID-19 transmission from asymptomatic animal handlers at a Gauteng zoo not only posed a risk to endangered big cats kept in captivity...

WHO: Humanity’s biggest mistake has been to underestimate the coronavirus

Humanity’s biggest collective failing regarding COVID-19 has been underestimating it – and the virus has sequentially exploited the resulting opportunities – says Dr Mike...

Discovery Health’s large real-world analysis of Omicron

Discovery Health, South Africaʼs largest private health insurance administrator, has released at-scale, real-world analysis of the Omicron outbreak based on 211,000 COVID-19-positive test results...

South African sanitisers: Barely a quarter meet WHO virucidal standards

An analysis of South African hand-sanitisers found that barely a quarter conform to World Health Organization guidelines on the alcohol content necessary to have...

‘Strong evidence’ of COVID-19’s origin in Wuhan live-animal market

COVID-19’s Patient Zero was a woman working at China’s Wuhan animal market, not an accountant unconnected to the facility, as previously concluded by the...

Intravenous remdesivir reduced hospitalisation by 87% in high-risk COVID patients

A three-day course of intravenous remdesivir reduced the risk of hospitalisation by 87% versus placebo, in COVID-19 outpatients at high risk of progression to...

Vaccination 5x more effective against hospitalisation than prior COVID infection — CDC analysis

A nationwide analysis from the US Centers for Disease Control and Prevention (CDC) shows that mRNA COVID-19 vaccines are associated with significantly more immunity...

Neurological complications after first dose of Pfizer and AstraZeneca vaccines

Increased but low risk of Guillain–Barré syndrome and Bell’s palsy after first dose of the Oxford–AstraZeneca  vaccine, as well as of haemorrhagic stroke after...

Anti-vaccine chiropractors: A rising force of misinformation

An Associated Press investigation has found that in the United States, “a major purveyor” of anti-vaccine activism and misinformation is a small but vocal...

UK reports 30,000 “yellow card” menstrual-related vaccination occurrences

Medical professionals are increasingly being approached by women who have experienced changes to periods and unexpected vaginal bleeding after being vaccinated, writes Dr Victoria...

Healthy boys at greater risk from vaccination than COVID itself — US analysis

Healthy boys may be more likely to be admitted to hospital with post-vaccination myocarditis, a rare side-effect of the Pfizer/BioNTech COVID vaccine, than with...

Acute COVID: 35% higher risk of substantial decline in kidney function

COVID-19 survivors exhibited substantially increased risk of adverse kidney outcomes in the post-acute phase, found an analysis of 1.7m US military veterans’ records, in...

New COVID variant — More mutated, more transmissible, and all over SA

A coronavirus variant first detected in South Africa and since found in England, China, the Democratic Republic of the Congo, Mauritius, New Zealand, Portugal and Switzerland, could be more infectious than other mutations and...

Doctors are ambivalent about the looming catastrophe of ‘long COVID’

The medical community has been ambivalent about recognising “ long COVID” as a legitimate disease or syndrome, partly because it currently has no accepted...

Efficacy and safety of Pfizer-BioNTech vaccine after six months

The Pfizer-BioNTech (BNT162b2) vaccine prevents COVID-19 effectively for up to six months after the second dose across diverse populations, including 100% efficacy against the...

CDC warns: Delta more transmissible than Ebola, as contagious as chickenpox

The Delta variant is more transmissible than Ebola and as infectious as chickenpox, warns the US Centers for Disease Control and Prevention, writes MedicalBrief....

Study supporting Ivermectin for COVID withdrawn over ethical concerns

The efficacy of Ivermectin, the drug being unofficially promoted worldwide for treating COVID-19, is again under challenge after a much cited study suggesting the...

COVID-19 vaccines highly effective in most people in clinical risk groups — Massive UK study

The Pfizer/BioNTech and AstraZeneca/Oxford COVID-19 vaccines are as effective at preventing symptomatic illness in people with underlying medical conditions as in the rest of...

Azithromycin doesn't reduce hospitalisation or mortality risk in mild-to-moderate COVID-19

A randomised clinical trial conducted in the United Kingdom found that use of the antibiotic azithromycin in patients with mild-to-moderate COVID-19 did not reduce...

Long COVID: More than a quarter of patients still symptomatic after six months — Swiss study

In a study of adults from the Zurich general population who were infected with COVID-19 in 2020, more than a quarter report not having...

COVID-19 antibodies persist at least nine months after infection — Assay tests in Italy

Researchers from the University of Padua and Imperial College London tested more than 85% of the 3,000 residents of Vo’, Italy, in February/March 2020...

Delta variant: Not just hyper-contagious but also multiplies more rapidly inside respiratory tract

After months of data collection, scientists agree: the Delta variant is the most contagious version of the coronavirus worldwide. It spreads about 225% faster...