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Better mental health management improves Tx outcomes

Improved management of depression and other mental health disorders has the potential to improve the outcomes of HIV treatment programmes, Pamela Collins of the National Institute of Mental Health, Bethesda, Maryland told the Conference on Retroviruses and Opportunistic Infections (CROI 2017) in Seattle. Mental health treatment should be integrated into HIV services in resource-limited settings, she said.

Diabetes, cardiovascular disease, cancers, lung disease and other non-communicable diseases have an increasing impact on the health and quality of life of people living with HIV. Health services in low- and middle-income countries have been slow to implement programmes to prevent, screen for and treat these diseases, but a number of projects have shown that this work can be integrated with HIV care.

Collins noted that mental health disorders are now considered alongside non-communicable diseases in the third Sustainable Development Goal. But she said that whereas other non-communicable diseases increasingly affect people as they get older, the greatest burden of mental health problems falls in adolescence and young adulthood. Around three-quarters of mental health disorders have begun by the age of 24.

A global meta-analysis showed that 18% of people had experienced a mental health disorder in the previous year and 29% had done so in their lifetime (23% in low- and middle-income countries, 32% in high-income countries). However, few people receive the treatment they need, especially in resource-limited settings.

Mental health disorders commonly occur in people living with chronic health conditions (including HIV). The evidence from a range of conditions, such as diabetes, asthma and arthritis, is that having untreated depression as well as another health condition is associated with being less able to function and having poorer health status.

Depression is the most common mental health co-morbidity experienced by people living with HIV. In sub-Saharan Africa, the average prevalence of depression in people living with HIV is around 8% (similar to that seen in general population samples in the region), but can be much higher in some groups.

Depression is more commonly experienced by women, older people, those who are unemployed, people with low CD4 cell counts and people with more physical symptoms. People who have experienced childhood trauma or negative life events, and those with less social support are more likely to be depressed.

The relationship between mental health disorders and HIV works in both directions, Collins said. Mental disorders can be a risk factor or increase vulnerability to HIV infection. At the same time, people may experience depression or anxiety as they adjust to a diagnosis or live with a chronic illness. Moreover, neuro-psychiatric effects of the virus can in some cases lead to cognitive changes or dementia.

Providing HIV medical care and antiretroviral treatment specifically is in itself associated with improvements in mental health, due to the improvements in physical health which it brings. Nonetheless, a number of cases of depression persist, requiring intervention above and beyond the provision of antiretroviral therapy. Moreover, around 15% of adults and 26% of adolescents living with HIV cite feeling depressed or overwhelmed as a barrier to HIV treatment adherence.

A meta-analysis of studies mostly conducted in the US suggested that treating depression can improve adherence to antiretroviral therapy. When the interventions specifically targeted depression (rather than treating it as a secondary objective), results were better. Furthermore, the greatest impact was seen in patients with a low CD4 cell count or moderate to severe depression symptoms, or when treatments of a longer duration were used.

A recent prospective cohort study from Tanzania found that 58% of women beginning HIV treatment had symptoms consistent with depression, with around a third mentioning each of the following – loss of sexual interest, low energy, worrying too much and blaming themselves. One in six women said they sometimes felt like ending their life. Depression was associated with mortality in this study. Two years after beginning HIV treatment, 6.6% of women with depression symptoms and 3.7% of other women had died. After adjustment for other factors, women with depression symptoms were twice as likely to have died.

One of the challenges of addressing mental health is the dearth of mental health workers in many settings. There is one mental health worker per 100,000 people in low-income countries, compared to 52 workers per 100,000 people in high-income countries.
Task shifting is therefore key.

In a recently published randomised controlled trial, lay health workers in Zimbabwe were trained and supervised to provide individual problem-solving therapy. Those who received the intervention (42% of whom had HIV) had fewer depression symptoms after six months. The evidence base for task shifting in mental health in resource-limited settings has grown considerably in recent years, Collins said.

To give another example, a small pilot study in Cameroon used depression care managers, a non-physician role that can be fulfilled by nurses or social workers after training. Working within HIV clinical services, they provided support to an HIV clinician, giving advice on depressive symptoms and the use of antidepressant medication, based on a treatment algorithm.

After four months, nearly all participants had a considerable improvement in their depressive illness. The intervention also appeared to have an impact on HIV outcomes, including CD4 cell count, viral load, symptoms and adherence.

In Uganda, a group support psychotherapy intervention for people with HIV, using problem-solving and cognitive-behavioural approaches, reduced depression symptoms. Support groups exist in many settings, Collins said, but can be enhanced by adding evidence-based interventions for depression.

Integrating care for mental disorders and HIV is feasible, she said. This means making the screening and treatment of mental disorders a normative part of HIV care. Consensus needs to be achieved on who delivers services – nurses, adherence counsellors, community health workers, peers or other groups. People seeking services, healthcare providers, managers and policymakers need to be involved in decision making about service integration, she said.

Mental and substance use disorders are highly prevalent and rank among the leading causes of disability worldwide, accounting for nearly 20% of the global burden of disability in 2015. Among these, depressive disorders contribute the greatest burden and are the most prevalent, with an estimated 311 million cases globally in 2015. These are disabling disorders of youth, responsible for a greater percentage of disease burden among 15-49 year olds, thus affecting educational, employment, and relationship functioning. Notably, mental disorders frequently co-occur with HIV, both as risk factors and sequelae of HIV infection. Major depression occurs nearly twice as often among people with HIV infection and is associated with poor adherence to care, lower likelihood of virologic suppression, greater morbidity and mortality. Depression is associated with greater mortality in the initial years after antiretroviral initiation. Whereas access to outpatient mental health services for people with HIV care occurs frequently in wealthy countries, several barriers have impeded mental health care access in low-and middle-income countries (LMICs) with high HIV prevalence. The dearth of mental health human resources and limited investment in mental health in LMICs reduce access to care. As a result, most health professionals do not identify or treat disorders like depression in community care settings. The social stigma associated with psychiatric institutional care creates an additional barrier to seeking mental health care. The treatment landscape for HIV and depression has changed in recent years. Investments in HIV care and treatment have led to a chronic care infrastructure in some LMICs that can be leveraged to manage other potentially chronic, remitting conditions like depression. A growing evidence base for the use of task-shifting to deliver mental health services in LMICs is expanding options for non-specialists to treat depression. Recent trials demonstrate that lay health workers, nurses, and peers can be trained to effectively deliver evidence-based depression care in HIV and non-HIV treatment contexts. In addition, several validation studies show that commonly used assessments for depression can be meaningfully applied in varied contexts among HIV-positive patients. These developments, along with new goals for epidemic control, make the integration of HIV and depression care in LMICs necessary and feasible.

Pamela Collins

[link url=""]Aidsmap material[/link]
[link url=""]CROI 2017 abstract 153[/link]

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