Coronary heart disease (CHD) is a leading cause of death for men in the US. Both cardio-respiratory fitness (CRF) and the blood triglyceride/high-density lipoprotein ratio (TG:HDL ratio) are strong predictors of death from CHD. Two studies highlight the importance of CRF on subsequent CVD and mortality risk. These articles contribute substantive evidence on the importance of achieving moderate to high levels of CRF in both adults and children.
In an investigation led by Dr Stephen W Farrell, of The Cooper Institute, Dallas, researchers found strong evidence that moderate-to-high level of fitness counteracted some of the negative effects of a high TG:HDL ratio.
"While it is still extremely important to measure traditional risk factors such as resting blood pressure, blood cholesterol, triglyceride, and glucose levels, having a measure or estimate of the patient's cardio-respiratory fitness level gives us additional information regarding cardiovascular disease risk," explained Farrell. "The results of this study support this recommendation. Regardless of whether the blood TG:HDL ratio was low or high, having at least a moderate level of fitness provided some protection from CHD death when compared to having a low level of fitness."
A total of 40,269 men received a comprehensive physical examination between 1 January, 1978 and 31 December, 2010. The exam included a maximal treadmill exercise test to measure cardio-respiratory fitness level, and also included measurement of the blood TG:HDL ratio. This ratio is easily calculated by taking the fasting blood triglyceride level and dividing it by the blood HDL cholesterol level. A lower ratio is an indicator that insulin is working well, while a higher ratio indicates resistance to insulin. Higher ratios also indicate an increased risk of future pre-diabetes, type 2 diabetes, and cardiovascular disease.
The participants, categorised into low, moderate, and high CRF groups, were followed for an average period of 16.6 years, during which time 556 deaths due to coronary heart disease (CHD) occurred. Moderate to high levels of fitness provided significant protection from CHD death. Lower values for the TG:HDL ratio also provided significant protection.
The lowest risk of CHD death was seen among high fit men in the lowest category of TG:HDL ratio, while the highest risk of CHD death was seen among low fit men in the highest category of TG:HDL ratio. Within each of the four categories of TG:HDL ratio, having a moderate to high level of fitness provided significant protection against CHD death when compared to having a low level of fitness. Therefore, knowing the patient's fitness level as well as their TG:HDL ratio provides much more information about CHD risk status than just knowing one or the other. When used in combination with other risk factors, such as the patient's blood pressure, bloodwork, family history, etc, measuring or estimating the patient's level of CRF can result in a much more accurate determination of their cardiovascular disease risk status.
There are also some studies that indicate that the TG:HDL ratio can be a proxy for LDL particle size, whereby small dense LDL particles are more likely to form plaques in blood vessels than large, less-dense particles.
It has often been said that "Exercise is Medicine." Many risk factors for chronic disease can be prevented or treated with sufficient amounts of exercise, weight loss, and healthy diet. Avoiding tobacco in all forms is also a must.
In another study researchers from several universities and institutes in Spain highlight the importance of monitoring CRF for early detection of present and future cardiovascular risk in youth. They describe how measuring CRF in 6- to 10-year-olds and later in 8- to 12-year-olds can reveal indicators of increased cardiovascular disease (CVD) risk later in life.
Lead investigator Dr José Castro-Piñero, from the department of physical education, School of Education, University of Cádiz, Puerto Real, Spain, noted, "Although CVD events occur most frequently during or after the fifth decade of life, there is evidence indicating that CVD precursors have their origin in childhood and adolescence. Moreover, adverse CVD risk factors during childhood have been found to track into adulthood. Consequently, early detection and diagnosis of CVD risk factors in children and adolescents will contribute to the development of effective prevention programmes, counselling, school-based strategies, and public health policies."
Participants were part of the UP&DOWN study of 2,225 youths between 6 and 18 years of age, and for this study, 213 primary schoolchildren were tested. CRF was expressed as an oxygen consumption value (units of mL/kg per minute) calculated from a shuttle-run test. Other data collected included skinfold thickness, blood pressure, serum triglyceride (TG) levels, total cholesterol (TC) level, high-density lipoprotein cholesterol (HDL-C) level, glucose level, insulin level, and CRF. From these data, single CVD risk factors were determined as well as an overall CVD risk score.
Researchers determined that several single CVD factors increased during the two-year follow-up period for both boys and girls, while overall CVD risk score increased significantly only for boys. Maximum oxygen consumption decreased for both boys and girls. Boys were about seven times more likely to have a favourable CVD risk score at follow-up if their CRF level was at least 39.0 mL/kg per minute at the beginning of the study. Girls were more than four times as likely to have favourable CVD risk with CRF of at least 37.5 mL/kg per minute at the beginning of the study.
In an accompanying editorial, Dr Carl J Lavie, of the John Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine, New Orleans, observed that collectively the data presented in the study by Farrell et al support significant public health messages. First, CRF significantly modulates CVD risk associated with dyslipidemia. Second, accumulating 7 to 14 miles per week of moderate-intensity exercise, such as running, can potentially lower the risk associated with increased TG:HDL-C levels as reported by the current study. Finally, CRF must be considered by health care professionals when CVD risk is assigned to patients.
Lavie further stated that by focusing on young children and adding an important longitudinal analysis of how CRF changes relate to changes in CVD risk, Castro-Piñero et al have added two significant dimensions to the existing literature.
Abstract 1
Objective: To examine the prospective relationships among cardiorespiratory fitness (CRF), fasting blood triglyceride to high density lipoprotein cholesterol ratio (TG:HDL-C), and coronary heart disease (CHD) mortality in men.
Methods: A total of 40,269 men received a comprehensive baseline clinical examination between January 1, 1978, and December 31, 2010. Their CRF was determined from a maximal treadmill exercise test. Participants were divided into CRF categories of low, moderate, and high fit by age group and by TG:HDL-C quartiles. Hazard ratios for CHD mortality were computed using Cox regression analysis.
Results: A total of 556 deaths due to CHD occurred during a mean ± SD of 16.6±9.7 years (669,678 man-years) of follow-up. A significant positive trend in adjusted CHD mortality was shown across decreasing CRF categories (P for trend<.01). Adjusted hazard ratios were significantly higher across increasing TG:HDL-C quartiles as well (P for trend<.01). When grouped by CRF category and TG:HDL-C quartile, there was a significant positive trend (P=.04) in CHD mortality across decreasing CRF categories in each TG:HDL-C quartile.
Conclusion: Both CRF and TG:HDL-C are significantly associated with CHD mortality in men. The risk of CHD mortality in each TG:HDL-C quartile was significantly attenuated in men with moderate to high CRF compared with men with low CRF. These results suggest that assessment of CRF and TG:HDL-C should be included for routine CHD mortality risk assessment and risk management.
Authors
Stephen W Farrell, Carrie E Finley, Carolyn E Barlow, Benjamin L Willis, Laura F DeFina, William L Haskell, Gloria L Vega
Abstract 2
Objective: To examine the association between cardiorespiratory fitness (CRF) at baseline and cardiovascular disease (CVD) risk in 6- to 10-year-olds (cross-sectional) and 2 years later (8- to 12-year-olds [longitudinal]) and whether changes with age in CRF are associated with CVD risk in children aged 8 to 12 years.
Patients and Methods: Spanish primary schoolchildren (n=236) aged 6 to 10 years participated at baseline. Of the 23 participating primary schools, 22% (n=5) were private schools and 78% (n=18) were public schools. The dropout rate at 2-year follow-up was 9.7% (n=23). The 20-m shuttle run test was used to estimate CRF. The CVD risk score was computed as the mean of 5 CVD risk factor standardized scores: sum of 2 skinfolds, systolic blood pressure, insulin/glucose, triglycerides, and total cholesterol/high-density lipoprotein cholesterol.
Results: At baseline, CRF was inversely associated with single CVD risk factors (all P<.05) and CVD risk score at baseline and follow-up (P<.001). Cardiorespiratory fitness cutoff points of 39.0 mL/kg per minute or greater in boys and 37.5 mL/kg per minute or greater in girls are discriminative to identify CVD risk in childhood (area under the curve, >0.85; P<.001) and to predict CVD risk 2 years later (P=.004). Persistent low CRF or the decline of CRF from 6-10 to 8-12 years of age is associated with increased CVD risk at age 8 to 12 years (P<.001).
Conclusion: During childhood, CRF is a strong predictor of CVD risk and should be monitored to identify children with potential CVD risk.
Authors
José Castro-Piñero, Alejandro Perez-Bey, Víctor Segura-Jiménez, Virginia A Aparicio, Sonia Gómez-Martínez, Rocio Izquierdo-Gomez, Ascensión Marcos, Jonatan R Ruiz, Ascension Marcos, Ascension Marcos, Jose Castro-Piñero, Oscar L Veiga, Fernando Bandres, David Martinez-Gomez, Jonatan R Ruiz, Ana Carbonell-Baeza, Sonia Gomez-Martinez, Catalina Santiago, Ascension Marcos, Sonia Gomez-Martinez, Esther Nova, Ligia-Esperanza Diaz, Belen Zapatera, Ana M Veses, Aurora Hernandez, Alina Gheorghe, José Castro-Piñero, Jesus Mora-Vicente, Jose L Gonzalez-Montesinos, Julio Conde-Caveda, Jonatan R Ruiz, Francisco B Ortega, Carmen Padilla Moledo, Ana Carbonell Baeza, Palma Chillon, Jorge del Rosario Fernandez, Ana Gonzalez Galo, Gonzalo Bellvis Guerra, Alvaro Delgado Alfonso, Fernando Parrilla, Roque Gomez, Juan Gavala, Oscar L Veiga, H Ariel Villagra, Juan del-Campo, Carlos Cordente, Mario Diaz, Carlos M Tejero, Aitor Acha, Jose M Moya, Alberto Sanz, David Martinez-Gomez, Veronica Cabanas-Sanchez, Gabriel Rodriguez-Romo, Rocio Izquierdo, Laura Garcia-Cervantes, Irene Esteban-Cornejo, Fernando Bandres, Alejandro Lucia, Catalina Santiago, Felix Gomez-Gallego
[link url="https://www.sciencedaily.com/releases/2017/11/171117195129.htm"]Elsevier material[/link]
[link url="http://www.mayoclinicproceedings.org/article/S0025-6196(17)30635-3/fulltext"]Mayo Clinic Proceedings abstract 1[/link]
[link url="http://www.mayoclinicproceedings.org/article/S0025-6196(17)30682-1/fulltext"]Mayo Clinic Proceedings abstract 2[/link]
[link url="http://www.mayoclinicproceedings.org/article/S0025-6196(17)30739-5/abstract"]Mayo Clinic Proceedings editorial[/link]