A study has found that among non-smokers who had diabetes, those who took the diabetes drug metformin had a decrease in lung cancer risk. "Metformin use was not associated with lung cancer risk when we looked at all patients with diabetes. However, our results suggest that risk might differ by smoking history, with metformin decreasing risk among nonsmokers and increasing risk among current smokers," said Dr Lori Sakoda, research scientist at the Kaiser Permanente Division of Research in Oakland, California. "Our results suggesting that the risk associated with metformin might differ by smoking history were unexpected," added Sakoda. "Additional large, well-conducted studies are needed to clarify whether metformin may be used to prevent lung or other cancers, particularly in specific sub-populations, such as non-smokers."
Some laboratory studies and a number of observational studies suggest that metformin may prevent cancer, but the data from human studies are conflicting, explained Sakoda. The researchers conducted this study to further clarify the association between metformin use and lung cancer risk.
Sakoda and colleagues conducted a retrospective cohort study of 47,351 diabetic patients (54% men), 40 years or older, who completed a health-related survey between 1994 and 1996. Information on their diabetes medications was collected from electronic pharmacy records. About 46% of them were “ever-users” of metformin, defined as those who filled two or more prescriptions within a six-month period. During 15 years of follow-up, 747 patients were diagnosed with lung cancer. Of them, 80 were never smokers, and 203 were current smokers.
Metformin use was not associated with lower lung cancer risk overall; however, the risk was 43% lower among diabetic patients who had never smoked, and the risk appeared to decrease with longer use. Non-smokers who used metformin for five years or longer had a 52% reduction in lung cancer risk, but this finding was not statistically significant. Metformin use for five or more years was associated with a 31% decrease in the risk for adenocarcinoma, the most common type of lung cancer diagnosed in non-smokers, and an 82% increase in the risk for small-cell carcinoma, a type of lung cancer often diagnosed in smokers, but neither of these findings were statistically significant.
[link url="http://www.aacr.org/Newsroom/Pages/News-Release-Detail.aspx?ItemID=663#.VNcRYuaUfE0"]American Association of Cancer Research release[/link]
[link url="http://cancerpreventionresearch.aacrjournals.org/content/8/2/174.abstract"]Cancer Prevention Research abstract[/link]