A British study has suggested a link between weight gain and having children later in life with a heightened risk of breast cancer, finding that women who had significant weight gain after 20 and had their first child after 30 – or not at all – were nearly three times more susceptible to breast cancer.
This increased risk was compared with women who gave birth earlier and maintained a stable weight.
Presented at the European Congress on Obesity in Malaga this week, the research, which has not yet been published in a peer-reviewed journal, highlights converging trends, reports The Independent.
Lead researcher Lee Malcomson of the University of Manchester noted the rise in overweight and obese women in the UK over the past decade, coupled with the increasing trend of delayed childbirth over the past 50 years.
Simultaneously, breast cancer diagnoses in women have reached an all-time high.
“More information about how age of motherhood and weight gain affects the risk of breast cancer would allow us to better work out who is most at risk of the disease and target lifestyle advice accordingly,” he said.
For the study, he and colleagues analysed data on 48 417 women typically aged 57 whose body mass index was in the overweight range, around 26.3.
The women were split into whether they had their first pregnancy early (before 30), late (30 and over), had not given birth, and also looked at weight gain in adulthood.
Weight gain was calculated by asking women to recall their weight at the age of 20 and subtracting it from their current weight.
The women were followed up for an average of 6.4 years, during which 1 702 were diagnosed with breast cancer.
The study results suggested that women with an early first pregnancy had greater weight gain during adulthood than those with a late first pregnancy, with 0.21kg of extra weight gain for each year earlier the pregnancy occurred.
An early first pregnancy also seemed to protect against post-menopausal breast cancer, which confirms previous research, while weight gain pushed up the risks, which has also been found before.
However, the study found no evidence that having a first pregnancy at an early age managed to offset the increased risk of breast cancer caused by weight gain.
Overall, women who had more than a 30% increase in weight during adulthood and either had their first child after age 30, or did not have children, were nearly three times more likely (2.73 times) to develop breast cancer than women who had an early first pregnancy and less than a 5% increase in adult weight.
Malcomson said: “Our study is the first to establish how weight gain and age of first birth interact to affect a woman’s risk of breast cancer.
“It is vital that GPs are aware that the combination of gaining a significant amount of weight and having a late first birth – or, indeed, not having children – greatly increases a woman’s risk of the disease.”
Dr Kotryna Temcinaite, head of research communications and engagement at Breast Cancer Now, said: “It’s important to remember that breast cancer risk is influenced by many different factors including genetics, lifestyle and environment, and many of these are out of our control.
“These findings add to our understanding of how pregnancy and weight gain throughout adulthood can influence someone’s chances of developing breast cancer after menopause, but we still need more research to fully understand the reasons behind it.”
See more from MedicalBrief archives:
Rising global obesity presents ‘unparalleled’ health threat – Lancet report
Pregnancy before 29 helps decrease later breast cancer risk
Breastfeeding after breast cancer a safe option – Italian studies
Excessive pregnancy kilos linked to earlier deaths – US study
Higher body fat link to lower breast cancer risk in pre-menopausal women