Research by an internationally recognised young biochemist from North-West University (NWU) suggests everyday foods like broccoli and rooibos tea could help protect the heart from cardiovascular diseases, which remain among the world’s leading killers.
This was the core finding of the PhD study by Dr Sinenhlanhla Mthembu, who explored plant-based compounds that could help counter heart damage caused by metabolic disorders.
Her study probed the pressing question of why cardiovascular complications continue to rise despite the availability of conventional therapies – with her findings pointing to affordable, plant-based interventions as a potential solution.
While the body naturally produces disease-fighting antioxidants such as coenzyme Q10, which is critical for heart health, metabolic complications such as dyslipidemia can disrupt these molecules, she said.
“Natural compounds like aspalathin from rooibos and sulforaphane from broccoli can restore antioxidants, improve energy metabolism and shield heart cells from oxidative damage,” she added. “This could improve outcomes for patients facing cardiovascular complications.”
Mthembu’s work has already made a mark, with 26 peer-reviewed publications and an h-index of 15, reflecting her growing influence in mitochondrial biology and cardiometabolic health.
Hailing from Bergville, KwaZulu-Natal, Mthembu completed her BSc, honours, and MSc degrees in biochemistry at the University of Zululand before joining the NWU in 2021 in collaboration with the South African Medical Research Council (SAMRC).
“The SAMRC is where my life changed,” she said. “I was introduced to state-of-the-art research equipment and mentored by my supervisor, Professor Sithandiwe Mazibuko-Mbeje, who guided me step by step.”
Global fellowships, awards
Her dedication to research has earned her international recognition. At the Young Scientists Forum in Turkey this year, she was the only South African and the only black candidate selected for a fellowship of the International Union of Biochemistry and Molecular Biology/Federation of European Biochemical Societies.
She also received the 2024 IUBMB MilliporeSigma ENABLE-Africa Fellowship in Singapore and the South African Women in Science Award DSI Esther Mahlangu Doctoral Fellowship.
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