Cochrane Collaboration in turmoil over expulsion of board member

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Peter Gøtzsche

Peter Gøtzsche

A the expulsion of a board member of the Cochrane Collaboration, one of medicine’s most respected bodies for its reviews of clinical research, has raised questions on the limits of free speech, when it is perceived to damage an organisation’s reputation for impartiality and reliability.

The Cochrane Collaboration is in turmoil as its annual meeting gets underway in Edinburgh, Scotland, after its governing board voted to expel a member. Stat News reports that the Cochrane Collaboration, which reviews the scientific literature in areas of clinical research and produces widely cited analyses that help guide clinical practice, kicked out a member who has been an outspoken critic of certain vaccines and has blasted the profession of psychiatry for pushing unsafe drugs on unsuspecting patients.

The report says the expulsion of Peter Gøtzsche sparked accusations that the Collaboration is too friendly toward the drug industry. Four other members of the organisation’s governing board resigned in response, citing concerns that the action “goes against Cochrane ethos.”

The vote appears to have been 6 of 13 in favour of the move, according to statements from the board members who resigned and Gøtzsche – short of a majority but enough to pass because only 11 voted.

“This unprecedented action taken by a minority of the Governing Board is disproportionate and damaging to Cochrane, as well as to public health interests,” Gøtzsche said in a letter.

The report says the Collaboration posted a statement, saying: “Cochrane’s Governing Board considered, as planned, the findings of an independent review and additional complaints related to the conduct of a Member.” The complaints were not specified, but the statement said the board’s co-chairs will provide more details “once this process is complete.”

Gøtzsche, the director of the Nordic Cochrane Centre, in Copenhagen, Denmark, has cast doubts about the safety of a vaccine against human papillomavirus (HPV), a cause of cervical cancer, and says psychiatry has “gone astray” by coercing patients into taking medication, such as antidepressants, they don’t want to use and that cause “brain damage” over the long run. “The way these drugs are used today cause(s) more harm than good. So, it would be better for us if the drugs didn’t exist.”

Gøtzsche, Cochrane member Tom Jefferson, and another colleague ruffled feathers at Cochrane with a recent article that criticised a recent paper from the Collaboration on the safety of the HPV vaccine. The paper prompted a rebuttal from Cochrane that dismissed the concerns and stood behind the original findings.

Hilda Bastian, a founding member of the Cochrane Collaboration and an influential writer about science, called the review “a manufactured controversy – a hatchet job by people with such strong intellectual and ideological biases, that they didn’t even pick up that some of their most implausible allegations were based on their own analytical and investigative slip-ups.”

The report says Gøtzsche, who was elected to the group’s board of governors in 2017, blamed the vote on his stance on the drug industry. “As most people know, much of my work is not very favourable to the financial interests of the pharmaceutical industry. Because of this Cochrane has faced pressure, criticism and complaints. My expulsion is one of the results of these campaigns.”

Jefferson is quoted in the report as saying that people he’s spoken to are outraged. “I’ve been in Cochrane 25 years, this is not how we do things,” he said. “Peter Gotzsche was a democratically elected member of the board. It’s really unheard of.”

At least one prominent scientist expressed alarm that the move to jettison Gøtzsche was an assault on free speech. John Ioannidis, of Stanford University, said he is “disturbed” by Gøtzsche’s expulsion and stressed the importance of heterodox views in science.

“I adore Peter for his courage and I highly value his major contributions to evidence-based medicine … even if I don’t agree with all of Peter’s views and inferences,” Ioannidis wrote to a group of more than 100 experts in evidence-based medicine. “I think it is important to make sure that people who disagree with us will get the most opportunity to express and support their views with arguments and evidence and, of course, not get expelled.”

But at least one other expert defended Cochrane. Allen Frances, chair of the department of psychiatry at Duke University, dismissed the notion that Gøtzsche was being unfairly muzzled. “This has nothing to do with freedom of speech,” Frances wrote in the thread that included Ioannidis. Rather, he said, Cochrane is justifiably concerned about remaining an “impartial evaluator of evidence” and providing reliable information to doctors and their patients.

“At least in psychiatry, Peter is anything but impartial,” Frances wrote. “He consistently expresses the most extreme views in the most dramatic and misleading way. His role at Cochrane lends its legitimacy to opinions that are dangerous to patients with severe mental illness. As an individual, Peter has total freedom to express extreme opinions, but he has no inherent right to cloak them with Cochrane’s hard-won mantle of neutrality.”

The report says the four board members who resigned in the wake of the vote said that “the expulsion of inconvenient members from the Collaboration goes against Cochrane ethos and neither reflects its founding spirit nor promotes the Collaboration’s best interests. We are concerned that these actions might cause great damage to the reputation of the Collaboration.”

The report quotes the governing board as saying that two other members had resigned because the “situation required further changes in the composition of the Board in order to comply with Cochrane’s Articles of Association.” Neither of the board’s co-chairs immediately responded to requests for comment.

“There appears to be no confidence in the management board at this point,” Jefferson said. “I think the only honourable thing for the rest of the board to do is resign.”

Stat News report
Letter
Cochrane Collaboration statement
Cochrane Articles of Association
BMJ article
Cochrane rebuttal
Hilda Bastian blog


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