A meta-analysis may provide clues for new bipolar treatments

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A meta-analysis of genome-wide association studies has identified six biological pathways that may be involved in the genetic predisposition to develop bipolar disorder, reports [s]News-Medical[/s]. Pathways for corticotropin-releasing hormone signalling, cardiac â-adrenergic signalling, phospholipase C signalling, glutamate receptor signalling, endothelin 1 signalling and cardiac hypertrophy signalling were all significantly associated with bipolar disorder in the study, conducted by Dr John Nurnberger and colleagues of [b]Indiana University School of Medicine[/b]. Nurnberger said that their results ‘may provide clues for new approaches to treatment and prevention’.

Full News-Medical report
JAMA Psychiatry abstract

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