A meta-analysis of genome-wide association studies has identified six biological pathways that may be involved in the genetic predisposition to develop bipolar disorder, reports [s]News-Medical[/s]. Pathways for corticotropin-releasing hormone signalling, cardiac â-adrenergic signalling, phospholipase C signalling, glutamate receptor signalling, endothelin 1 signalling and cardiac hypertrophy signalling were all significantly associated with bipolar disorder in the study, conducted by Dr John Nurnberger and colleagues of [b]Indiana University School of Medicine[/b]. Nurnberger said that their results ‘may provide clues for new approaches to treatment and prevention’.
[link url=http://www.news-medical.net/news/20140423/Meta-analysis-links-signalling-pathways-to-bipolar-disorder.aspx]Full News-Medical report[/link]
[link url=http://www.researchgate.net/publication/261520757_Identification_of_Pathways_for_Bipolar_Disorder_A_Meta-analysis]JAMA Psychiatry abstract[/link]