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Cumulative smoking especially associated with more severe COVID-19

People who have smoked for more than 30 pack-years –  a unit for cumulative smoking – are about twice as likely to be hospitalised and to die after testing positive for COVID-19 as non-smokers, according to a research letter.

The researchers looked at health records from 7,102 patients who were in Cleveland Clinic's COVID-19 registry from 8 March through 25 August, 2020. Of those, 84.8% had never smoked, 2.4% were current smokers, and 12.8% formerly smoked.

The investigators at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, and the Respiratory Institute, Cleveland Clinic, found that people who had smoked for more than 30 pack-years were 2.25 times more likely to be hospitalised after a positive COVID-19 test (95% confidence interval [CI], 1.76 to 2.88) and 1.89 times more likely to die following diagnosis compared with non-smokers (95% CI, 1.29 to 1.76).

Those who smoked from 0 to 10 pack-years and 10 to 30 pack-years also showed some increased likelihood of adverse COVID outcomes. Using the same multivariable logistic regression model, which adjusted for age, race, and gender, the researchers found that the odds ratio for hospitalisation was 0.99 and 1.41, respectively, and that odds ratio for death was 1.66 and 1.47, respectively.

"We have demonstrated in this single central registry of patients who tested positive for COVID-19 that increased cumulative smoking was associated with a higher risk of hospitalisation and mortality from COVID-19 in a dose-dependent manner," the researchers write, adding, "The association between cumulative smoking and adverse COVID-19 outcomes is likely mediated in part by comorbidities."

 

Study details
Association of Smoking and Cumulative Pack-Year Exposure With COVID-19 Outcomes in the Cleveland Clinic COVID-19 Registry

Katherine E Lowe, Joe Zein, Umur Hatipoğlu, Amy Attaway

Published in JAMA Internal Medicine on 7 November 2020

Abstract
There is limited and contradictory evidence on the association of smoking status with adverse outcomes of severe acute respiratory syndrome coronavirus 2 infection.1-3 Furthermore, current smoking status does not encompass the cumulative effect of smoking. To our knowledge, no studies have assessed the cumulative effect of smoking over time, as measured by pack-years, though a single study of coronavirus disease 2019 (COVID-19) in a small cohort of 102 patients with lung cancer found that the patients with severe outcomes had a higher average pack-year history (30 vs 20 years).4 We hypothesize that there is an adverse association of cumulative smoking exposure, as measured by pack-years, with outcomes of patients with COVID-19.
Methods
The Cleveland Clinic initiated a COVID-19 registry starting on March 8, 2020, that includes all patients tested for COVID-19 within the Cleveland Clinic Health system in Ohio and Florida. Basic demographic information was collected during testing, including age, height, weight, self-reported gender, self-reported race, and select comorbidities. Additional data on comorbidities, medications, and outcomes were extracted from patient electronic medical records.5 The Cleveland Clinic Institutional Review Board approved this study and waived the need for patient informed consent owing to use of deidentified database information on study participants.
Adults who tested positive for COVID-19 between March 8, 2020, and August 25, 2020, and who had full smoking information recorded were included in the cohort. We classified patients based on their cumulative recorded smoking exposure. Those who reported that they were never smokers were compared with patients reporting 0 to 10 pack-years, 10 to 30 pack-years, and more than 30 pack-years. Demographic differences between these groups and previous literature on the risk factors of adverse COVID-19 outcomes informed the study modeling.1,3,5,6 We used multivariable logistic regression models to determine the odds ratio for hospitalization given a positive test, admission to the intensive care unit given hospitalization, and death given a positive COVID-19 test for each pack-year cohort compared with never smokers. Regression models were run unadjusted, adjusted for identified confounders (age, race, and gender) and adjusted for mediators (adding coronary artery disease, hypertension, chronic obstructive pulmonary disease, diabetes, use of angiotensin receptor blockers, and use of oral or inhaled corticosteroids). We used likelihood ratio tests to determine whether a given covariate would remain in the model.
Results
Of the 7102 patients included in the cohort, 6020 (84.8%) were never smokers, 172 (2.4%) were current smokers, and 910 (12.8%) were former smokers. All demographics are summarized in Table 1, and the results of logistic regression analyses are summarized in Table 2. The findings showed a dose-response association between pack-years and adverse COVID-19 outcomes. Patients who smoked more than 30 pack-years had a 2.25 times higher odds of hospitalization (95% CI, 1.76-2.88), and these heavy smokers were 1.89 times more likely to die following a COVID-19 diagnosis (95% CI, 1.29-1.76) when compared with never smokers. The association between cumulative smoking and adverse COVID-19 outcomes is likely mediated in part by comorbidities. The odds ratios for all adverse outcomes were attenuated in the mediation models. There was no evidence of effect modification by smoking status; similar odds ratios were seen in both current and former smokers.
Discussion
The results of this study suggest that cumulative exposure to cigarette smoke is an independent risk factor for hospital admission and death from COVID-19. Smoking is imperfectly classified in patient electronic medical records, and former smokers are potentially classified as never smokers, while pack-years may be underrecorded. However, this misclassification is likely to bias the present results toward the null, which would underestimate the association of cigarette smoking on adverse COVID-19 outcomes. The limitations on who has access to care at tertiary medical centers in the United States prevent generalizability to the whole population. The patients with complete data in this study are likely to be wealthier and have more consistent access to health care, as pack-years of smoking was typically collected during previous visits to the Cleveland Clinic. Nevertheless, we have demonstrated in this single central registry of patients who tested positive for COVID-19 that increased cumulative smoking was associated with a higher risk of hospitalization and mortality from COVID-19 in a dose-dependent manner.

 

[link url="https://www.cidrap.umn.edu/news-perspective/2021/01/covid-19-scan-jan-26-2021"]CIDRAP material[/link]

 

[link url="https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2775677"]JAMA Internal Medicine research letter[/link]

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