Healthcare providers challenged on failure to inform HIV patients

Organisation: Position: Deadline Date: Location:

Healthcare providers should inform all patients with HIV they cannot transmit HIV to a sexual partner when their viral load is undetectable, argue the authors of a strongly worded comment. The authors note that despite overwhelming scientific data supporting the undetectable = untransmittable (U=U) message, significant numbers of healthcare providers do not educate their patients about U=U when telling them their viral load is undetectable.

“Providers caring for patients with HIV should universally inform their patients about U=U as part of their routine care,” write Dr Sarah Calabrese of George Washington University and Professor Ken Mayer of the Harvard Medical School and Fenway Institute. “Conveying benefits and risks surrounding any treatment is fundamental to patients’ decision making, and this HIV treatment benefit should be no exception.”

Four rigorous studies involving HIV serodiscordant couples have failed to find a single proven case of sexual transmission of the virus when the HIV-positive partner is taking antiretroviral therapy and has a stable undetectable viral load. The evidence supporting U=U is robust in both male-female and male-male couples. The World Health Organisation (WHO) and more than 750 organisations worldwide agree that people with HIV whose viral load is stably suppressed cannot sexually transmit the virus.

However, recent research suggests that a significant proportion of healthcare providers are not educating their patients about U=U. An international survey involving more than 1000 providers found that only 77% of infectious disease specialists and 42% of primary care physicians communicate the U=U message when telling patients their viral load is undetectable. Reasons included disbelief (not accepting that U=U), a perception that U=U would undermine personal responsibility and concerns about patients’ behaviour and understanding.

“With evidence supporting undetectable = untransmittable (U=U) now overwhelming, providers should be routinely communicating the message to all of their patients living with HIV,” Calabrese and Mayer say.

The authors note that informing patients about U=U has numerous individual and public health benefits: encourage patients to start and adhere to antiretroviral therapy, and maintain an undetectable viral load; psychosocial benefits, enabling individuals to have intimate sexual relationships without fear, reducing internalised stigma and alleviating anxiety about the possibility of transmission; help reduce HIV incidence by encouraging engagement in the HIV treatment cascade; and accelerate reforms in government policy and the law, especially concerning the criminalisation of HIV exposure and non-disclosure.

There is still unawareness and misinformation about U=U in the communities most affected by HIV, including gay communities. Increasing knowledge and understanding of U=U might reduce HIV-related stigma in the broader community, encourage testing and lessen anxiety about acquiring HIV.

The authors express concern that people who cannot access HIV therapy because of cost, criminalisation or discrimination will not benefit from U=U, exacerbating existing health inequalities. “However, for the U=U message to be withheld from any person living with HIV is inexcusable, particularly in settings where treatment is accessible,” they conclude.

As scientific knowledge surrounding the link between HIV viral suppression and transmission risk evolves, messaging to patients must be updated accordingly. Presenting the results of the multisite, observational PARTNER2 study at the 22nd International AIDS Conference, Alison Rodger reported that no phylogenetically linked infections occurred following more than 76 000 condomless sex acts between virally suppressed men and their HIV-negative male partners.
This finding reinforces existing consensus by WHO and more than 750 other organisations worldwide that people whose HIV viral load is stably suppressed cannot sexually transmit the virus.
With evidence supporting undetectable=untransmittable (U=U) now overwhelming ( table), providers should be routinely communicating the message to all of their patients living with HIV.

Sarah K Calabrese, Kenneth H Mayer

Aidsmap material
The Lancet HIV comment

Receive Medical Brief's free weekly e-newsletter

Related Posts

Thank you for subscribing to MedicalBrief

MedicalBrief is Africa’s premier medical news and research weekly newsletter. MedicalBrief is published every Thursday and delivered free of charge by email to over 33 000 health professionals.

Please consider completing the form below. The information you supply is optional and will only be used to compile a demographic profile of our subscribers. Your personal details will never be shared with a third party.

Thank you for taking the time to complete the form.