Maria Branyas Morera, then the world’s oldest living person, had one last request before she died last year. “Please study me,” she said to Dr Manel Esteller, chairman of genetics at the University of Barcelona’s School of Medicine, Spain.
The New York Times reports that after she died last summer at 117, Esteller and a large cohort of colleagues fulfilled her wish. They examined her blood, saliva, urine and stool to try to learn why she lived so long.
The answer in part, according to a paper published last week in the journal Cell Reports Medicine, is that she took care of herself. She followed a Mediterranean diet, did not smoke or drink, and walked an hour a day until the early 2000s when doing so became too difficult.
And she won the genetic lottery with variants that, the researchers said, could predict longevity. These genetic variants have been reported to protect against common risk factors like high cholesterol levels, dementia, heart disease and cancer.
“She had cells that seemed younger than her age,” Esteller said.
The microbes that lived in and on her body, or her microbiome, are associated with low levels of inflammation, he added. Her microbiome had an abundance of a type of beneficial bacteria, Bifidobacterium, whose growth can be spurred by bacteria in yoghurt. Morera ate three yoghurts a day.
“High levels of inflammation are related to advanced ageing,” Esteller said.
Immaculata De Vivo, a molecular geneticist at Harvard University who was not involved in the study, said the researchers’ explanations for Branyas’ longevity were “scientifically reasonable”.
But, she cautioned, “it’s always important to be careful when interpreting results from individual cases, as opposed to large, well-controlled population studies”.
“While genetics and metabolic factors might tilt the odds for or against disease, disease causation is generally a matter of probabilities rather than absolutes,” she added.
In other words, good genes and microbiomes won’t keep you alive on their own.
Dr Mary Armanios, an oncologist and geneticist at Johns Hopkins School of Medicine, was less convinced. She questioned claims that certain genetic variants can predict longevity.
“The genetics of longevity are notoriously confusing,” she said. When researchers searched for variants linked to a long life, they compared the genes of younger people with those of people who were centenarians. But, she said, researchers don’t know if those younger people will live to be 100.
“What you want is a genetic profile that will predict,” she said. And that is hard to come by.
Armanios cautioned that genetics and a good microbiome are not even close to the whole story of why some people live so long. She noted that there are enormous differences in life expectancy linked to education and income levels. In Baltimore, in the USA for instance, she said, that adds up to a 20-year difference between people in the inner city and those in the suburbs.
“I do think there are obviously bad genetics that limit lifespan,” she said. “But I am not sure good genetics are sufficient to overcome socioeconomic limitations.”
Branyas, for whatever reason, seemed exceptionally resilient.
She was born in San Francisco in 1907. Her parents were from Spain but had gone to the United States for work. When Branyas was eight, her father died, and she and her mother moved back to Spain.
She married and had a son – who died at 52 – and two daughters, who are now 92 and 94.
Members of her extended family died from common causes: Alzheimer’s disease, an accident, cancer, TB, kidney failure, heart disease. Branyas lived on and on.
She seemed to have had all the hypothesised prerequisites for a long life. If the genetic variants have the proposed effects, she was primed to avoid chronic disease. And her lifestyle seemed ideal.
She had a close circle of family and friends, Esteller said, adding that as her friends died, she made new ones. She and her family lived in the same town.
She lived independently until 2001, when difficulty in walking led her to enter a nursing home. She played the piano until about five years ago.
“She lived a healthy life,” Esteller said.
Study details
The multiomics blueprint of the individual with the most extreme lifespan
Eloy Santos-Pujol, Aleix Noguera-Castells, Marta Casado-Pelaez et al.
Published in Cell Reports Medicine on 24 September 2025
Summary
Extreme human lifespan, exemplified by supercentenarians, presents a paradox in understanding ageing: despite advanced age, they maintain relatively good health. To investigate this duality, we have performed a high-throughput multiomics study of the world’s oldest living person, interrogating her genome, transcriptome, metabolome, proteome, microbiome, and epigenome, comparing the results with larger matched cohorts. The emerging picture highlights different pathways attributed to each process: the record-breaking advanced age is manifested by telomere attrition, abnormal B cell population, and clonal haematopoiesis, whereas absence of typical age-associated diseases is associated with rare European-population genetic variants, low inflammation levels, a rejuvenated bacteriome, and a younger epigenome. These findings provide a fresh look at human ageing biology, suggesting biomarkers for healthy ageing, and potential strategies to increase life expectancy. The extrapolation of our results to the general population will require larger cohorts and longitudinal prospective studies to design potential anti-aging interventions.
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