The US Centres for Disease Control and Prevention has recently recommended the use of antiviral drugs to help treat influenza, in a year when the available vaccine is not a good match for the current strain. Now, new evidence about a popular antiviral – often criticised as ineffective – shows that it can alleviate symptoms and prevent respiratory complications.
Research by the University of Michigan, the London School of Hygiene and Tropical Medicine and the University of Alabama found that Oseltamivir, marketed as Tamiflu, shortens the duration of symptoms by about one day and reduces by 44% respiratory infections that sometimes develop, said study co-author Dr Arnold Monto, the Thomas Francis J Collegiate Professor of Public Health at the University of Michigan School of Public Health.
"This is the first patient-level analysis of how well this drug works. Previous research has questioned its success and use in light of the side effects of nausea and vomiting, but the other studies combined those infected with influenza and those without, which diluted the positive effect in treatment," Monto said.
Researchers conducted meta-analysis of data from all published and unpublished clinical trials from 1997-2001 to determine effectiveness of the antiviral drug. The trials involved more than 4,300 patients, better than half of whom were treated with Oseltamivir. The research, used data made available by Tamiflu manufacturer Roche and analysed by an independent research group led by Joanna Dobson and Stuart Pocock of the London School of Hygiene and Tropical Medicine.
Oseltamivir is in a class of drugs known as neuraminidase inhibitors. They block the enzyme activity that occurs in influenza Type A and B viruses. Most of the patients studied had Influenza Type A, with the most prevalent strain reported as H3N2, the same one that is hitting much of the US this year. When used at the normal prescribed dosage of 75 mg twice a day for adults, within 36 hours following development of at least two flu symptoms, Oseltamivir was shown to reduce the duration of the illness by 21%. With the drug, symptom alleviation occurred, on average, at 98 hours compared with 123 hours with placebo. The researchers found no benefit in adults who did not have the flu virus, confirming the drug's role as an antiviral.
In addition to reducing the risk of respiratory tract infections requiring antibiotics, like pneumonia (4.9% had complications with the drug compared with 8.7% on placebo), Oseltamivir decreased hospital admissions by 63% (0.6% vs. 1.7%).
The researchers also found some of the same complications of the drug noted in previous research, with an increase in nausea (3.7%) and vomiting (4.7%). They did not find differences between the two groups with respect to development of neurological or psychological disorders that had been raised in previous research.
[link url="http://ns.umich.edu/new/releases/22654-study-shows-tamiflu-gets-patients-back-on-their-feet-faster-reduces-flu-complications"]University of Michigan release[/link]
[link url="http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)62449-1/abstract"]The Lancet abstract[/link]
[link url="http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60074-5/abstract"]The Lancet comment summary[/link]