Tuesday, 9 August, 2022
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Pharmacology

High doses of hormone drug linked to meningioma risk – Meta-analysis

High doses of drug cyproterone acetate (CPA), a drug widely-used in the hormonal treatment of conditions like hirsutism, early puberty, and prostate cancer, have...

Pharmacotherapy more effective than lifestyle change for weight loss – Systematic review

Of all the available medications for treatment of overweight and obesity, phentermine–topiramate and GLP-1 receptor agonists proved the best drugs, found a systematic review...

Anxiety drugs/antidepressants linked to doubled risk of post-op delirium

People  admitted hip or knee surgery and taking a range of drugs commonly prescribed for  anxiety, insomnia and depression, were twice as likely to...

Viagra as a candidate drug for Alzheimerʼs disease — US prescription analysis

The erectile dysfunction drug Viagra may be linked to a 69% lower risk of Alzheimerʼs disease, found a US analysis of medical insurance data...

America’s Veteran Affairs shuns controversial Alzheimer's drug, noting 'known safety signal'

The US Department of Veterans Affairs has decided to not include Biogen’s pricey new Alzheimer’s drug Aduhelm (aducanumab) on its formulary, and its Personal...

NHS England to offer breakthrough treatment for sickle cell disease

Thousands of patients in England will benefit from the first treatment for sickle cell disease in two decades, the NHS has announced. Crizanlizumab, a “revolutionary”...

FDA gives approval to novel migraine prevention drug

Atogepant (Qulipta) has become the first oral calcitonin gene-related peptide (CGRP) receptor antagonist (gepant) specifically developed for migraine prevention to win US Food and...

Paracetamol: Precautions necessary during pregnancy — Consensus Statement

Paracetamol (acetaminophen) should be used only when medically indicated during pregnancy and at the lowest effective dose for the shortest possible time, according to...

Pharmacological BP reduction: Viable treatment option despite old age

Contrary to existing international guidelines on age-related blood-pressure thresholds, a meta-analysis in The Lancet found that pharmacological blood pressure reduction is effective into old...

Pharmacological BP reduction: Viable treatment option despite old age

Contrary to existing international guidelines on age-related blood-pressure thresholds, a meta-analysis in The Lancet found that pharmacological blood pressure reduction is effective into old...

At last, serious efforts to repurpose generic drugs to treat COVID-19

More than a year into the pandemic, billions of dollars have been spent on developing vaccines and expensive novel treatments, but very little on...

Meta-analysis: Beta-blockers not linked to depression or adverse mental health events

A meta-analysis of large-scale data from double-blind, randomised controlled trials does not support an association between β-blocker therapy and depression or other adverse mental...

94% of older adults are prescribed drugs that raise risk of falling

Nearly every older adult was prescribed a prescription drug that increased their risk of falling in 2017, according to new University at Buffalo research....

Pre-diagnosis aspirin use may lower colorectal cancer mortality — American Cancer Society

A study finds that long-term aspirin use before a diagnosis of colorectal cancer (CRC) may be associated with lower CRC-specific mortality, found an American...

Azithromycin in combination may increase risk for cardiac events

While azithromycin by itself is not associated with an increase in cardiac events, if the taken with certain other drugs cardiac events increased, found...

Overlooked Soviet-era Miramistin has 'enormous potential' as antiseptic

A little-known non-toxic antiseptic developed in the Soviet Union during the Cold War has enormous potential to beat common infections, say University of Manchester...

US long-term use of muscle relaxants has skyrocketed since 2005

US doctor visits for ongoing prescribing of skeletal muscle relaxant drugs tripled from 2005 to 2016, according to a study from researchers in the...

No association between price and efficacy of cancer drugs — four-nation study

In general, for Switzerland, Germany, Britain and the US, there is no association between clinical benefit of a cancer drugs and their prices, found...

Consumers stockpile unproven drugs to self-medicate against COVID-19

Consumers worldwide are stockpiling and self medicating on drugs — chloroquine, hydroxychloroquine, ritonavir and umifenovir — that have been hyped as cures on social...

Decades-old antidepressant may fend off prostate cancer's return

A MAO inhibitor drug called phenelzine represents a potential new treatment direction with fewer side effects for men with recurrent prostate cancer, researchers said....

Drug that eases symptoms of chronic cough may become first new therapy in 50 years

Effective treatments for cough are a significant unmet clinical need and the new drug Gefapixant, moving into phase-three trials, has the potential to be...

Prescribing macrolide antibiotics in first trimester increases birth defect risk

Children of mothers prescribed macrolide antibiotics during the first trimester of pregnancy are at an increased risk of major birth defects when compared with...

Yale study adds to evidence of diabetes drug's link to heart risk

Rosiglitazone was associated with a 33% increased risk of a composite cardiovascular event (heart attack, heart failure, cardiovascular and non-cardiovascular related death) compared with...

Long-term medication for schizophrenia is safe

A Karolinska Institutet data analysis suggests that long‐term antipsychotic use does not increase severe physical morbidity leading to hospitalisation, and is associated with substantially...

Two-fold increase in gabapentinoids use for cancer pain 'problematic' – study

As the opioid crisis unfolded, prescriptions for the narcotic alternative saw a two-fold increase despite unclear evidence of benefit for pain. Between 2005 and...

Interstitial cystitis medication may be toxic to the retina

A drug widely prescribed for a bladder condition for decades, now appears to be toxic to the retina, the light sensing tissue at the...

Antidepressants may reduce anxiety more than depressive symptoms

One of the most common antidepressants, sertraline, leads to an early reduction in anxiety symptoms, several weeks before any improvement in depressive symptoms, the...

Commonly used antibiotics may lead to heart problems

Fluoroquinolone antibiotic use is linked with a higher than twofold risk of aortic and mitral regurgitation, risk being highest with current use followed by...

Tramadol associated with significantly greater risk of hypoglycaemia

The opioid tramadol produced a 10-fold greater risk of developing hypoglycaemia than virtually every other opioid, found a US study. Since its approval in 1995,...

Cannabis flower may be an effective mid-level analgesic

Using the largest database of real-time recordings of the effects of common and commercially available cannabis products in the US, researchers at The University...

Statins’ potential to treat MS unrelated to lowering cholesterol

The widely prescribed statin, simvastatin, can medically help patients with secondary progressive multiple sclerosis (SPMS) – for reasons that might be unrelated to the...

Pure Omega 3 reduces risk of total ischaemic events

Taking a high dose of icosapent ethyl – a pure and stable prescription form of the omega-3 fatty acid known as EPA – significantly...

Considerable added benefit for new drug in the prophylaxis of migraine

The German Institute for Quality and Efficiency in Health Care (IQWiG) has found, overall, ndication of a considerable added benefit of erenumab, a new...

Misconceptions over penicillin allergy deprive patients of best treatment

Most patients who report having a penicillin allergy are not really allergic to this highly effective antibiotic, and they may be missing out on...

Little benefit from vitamin D supplements for over 70s

There is little benefit for those over 70 taking higher dose vitamin D supplements to improve their bone strength and reduce the risk of...

Variant of wasp venom to treat bacterial infections

Massachusetts Institute of Technology (MIT) researchers, using toxin found in a South American wasp, have created peptide variants potent against bacteria but nontoxic to...

Alirocumab lowers risk of additional heart attacks or stroke

In a clinical trial involving 18,924 patients from 57 countries who had suffered a recent heart attack or threatened heart attack, researchers found that...

Medical cannabis provides symptom relief for a myriad of complaints

Medical cannabis can provide statistically and clinically significant relief from symptoms from dozens of health conditions with relatively minimal negative side effects, according to...

Taking ayahuasca is like having a near-death experience – study

A psychedelic drug taken as part of the South American plant brew ayahuasca produces effects that are strikingly similar to near-death experiences, a study...

Anticonvulsants ineffective in treating lower back pain

Use of anti-convulsant drugs to treat low back pain has increased more than fivefold in the past decade, but a study finds they are...