An Australian man with heart failure has become the first person in the world to walk out of a hospital with a total artificial heart implant, with his doctors saying it had been an “unmitigated clinical success” after the man lived with the device for more than 100 days before receiving a donor heart transplant in early March.
The BiVACOR total artificial heart, invented by Queensland-born Dr Daniel Timms, is the world’s first implantable rotary blood pump that can act as a complete replacement for a human heart, using magnetic levitation technology to replicate the natural blood flow of a healthy heart.
The implant, still in the early stages of clinical study, has been designed for patients with end-stage biventricular heart failure, which generally develops after other conditions – most commonly heart attack and coronary heart disease, but also other diseases such as diabetes – have damaged or weakened the heart so that it cannot effectively pump blood through the body effectively.
Every year more than 23m people worldwide suffer from heart failure but only 6 000 will receive a donor heart, according to the Australian Government, which provided $50m to develop and commercialise the BiVACOR device as part of the Artificial Heart Frontiers programme.
The Guardian reports that the implant is designed as a bridge to keep patients alive until a donor heart transplant becomes available, but BiVACOR’s long-term ambition is for implant recipients to be able to live with their device without needing a heart transplant.
The patient, a man in his 40s from New South Wales who was experiencing severe heart failure, volunteered to become the first recipient of the total artificial heart in Australia and the sixth in the world.
The first five implants took place last year in the US and all received donor hearts before being discharged from hospital, with the longest time in between implant and transplant 27 days.
The Australian patient received the device on 22 November at St Vincent’s Hospital in Sydney in a six-hour procedure led by cardiothoracic and transplant surgeon Paul Jansz.
The patient, who declined to be identified, was discharged from the hospital with the implant in February. A donor heart became available to be transplanted in March.
Jansz said it was a privilege to be part of such an historic and pioneering Australian medical milestone.
Professor Chris Hayward, a cardiologist at St Vincent’s, said the BiVACOR heart would transform heart failure treatment internationally.
“The BiVACOR Total Artificial Heart ushers in a whole new ball game for heart transplants, both in Australia and internationally,” he said.
“Within the next decade we will see the artificial heart becoming the alternative for patients who are unable to wait for a donor heart or when a donor heart is simply not available.”
Professor David Colquhoun from the University of Queensland and board member of the Heart Foundation, who was not involved in the trial, said the success was a “great technological step forward for artificial hearts – bridging hearts – before transplant”.
But Colquhoun cautioned that the functioning time span of the artificial heart – more than 100 days – was still significantly less than that of a donor heart, which is more than 10 years (or 3 000 days).
Colquhoun said for that reason it was still “a long way to go” before the artificial heart could be considered a replacement for a heart transplant.
The implant is the first in a series of procedures planned in Australia as part of the Monash University-led Artificial Heart Frontiers Programme, which is developing three key devices to treat the most common forms of heart failure.
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