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New TB screening methods cut deaths in people with HIV
Screening for tuberculosis (TB) and intensified follow-up of TB cases in people starting antiretroviral therapy and urine-based screening of inpatients with HIV both have...
Third-line HIV regimens effective in resource-limited settings
Third-line regimens with darunavir/ritonavir and raltegravir are highly effective in certain patients with HIV in resource-limited settings, Healio reports according to researchers. Targeted real-time...
One-month TB prophylaxis as effective as 9-month regimen for people living with HIV
A one-month antibiotic regimen to prevent active tuberculosis (TB) disease was at least as safe and effective as the standard nine-month therapy for people...
Dolutegravir and Rifapentine study stopped due to serious toxicities
A study examining pharmacokinetic interactions between the first-line HIV drug dolutegravir and a once-weekly tuberculosis regimen was terminated early after NIH researchers found that...
Lymphoma treatment outcomes just as good for people with HIV
People with HIV treated for aggressive forms of non-Hodgkin lymphoma or Burkitt lymphoma appear no more likely to suffer a relapse after treatment than...
Alcohol use not affecting short-term rate of CD4 count decline
Unhealthy alcohol use did not affect the short-term rate of CD4 cell count decline in HIV-infected, antiretroviral treatment (ART)-naive individuals in Uganda, according to...
Death rates of Zambians on ART underestimated up to ninefold
People with HIV in Zambia were at least ten times more likely to die in the first two years after starting antiretroviral treatment (ART)...
Darunavir/ritonavir for ART-experienced patients
Darunavir/ritonavir is the most durable boosted protease inhibitor for antiretroviral (ART)-experienced patients, investigators from the EuroSIDA cohort report. Patients switching treatment to a darunavir/ritonavir...
Interpersonal psychotherapy delivered to HIV patients telephonically
Interpersonal psychotherapy is a common, in-person treatment for depression, but research from the University of Georgia found that this type of one-on-one therapy can...
In the HIV population, bone loss is greater among women
Bone mineral density declines twice as quickly among HIV-positive women than HIV-positive men, according researchers at the University of Colorado, University of Texas Health...
Perinatal safety outcomes with atazanavir and darunavir
Atazanavir and darunavir, two HIV protease inhibitors (PIs) commonly used during pregnancy, have similar safety and activity profiles, according to study findings.
Investigators from Italian...
TB treatment outcomes good for multidrug-resistant TB/HIV co-infected patients who start ART
Treatment of multidrug-resistant tuberculosis (TB) has comparable efficacy and survival rates in patients infected with HIV and not uninfected with HIV when patients with...
Many young women unworried about HIV despite multiple risk factors
Many adolescent girls and young women with multiple risk factors for infection with HIV do not consider themselves to be at high risk for...
SA study shows why some progress to Aids before others
HIV/Aids researchers have never understood why people infected with HIV developed Aids at different times‚ but now they suspect that it all has to...
Long-acting injectable ARVs are convenient and private
HIV-positive people who took injectable cabotegravir + rilpivirine every four or eight weeks as antiretroviral therapy found it more convenient and discreet than daily...
UNAIDS 90-90-90 goals short of projections in Africa survey
Fewer than half of the adolescent girls and young women living with HIV who were tested for the virus as part of door-to-door surveys...
TB biomarker predicts mortality risk in children with HIV
Children with HIV in Kenya whose urine samples tested positive for lipoarabinomannan (LAM) – biomarker of tuberculosis – had a nearly five-fold increased risk...
New surveillance model to improve HIV treatment strategies
A study that seeks to better ascertain HIV mortality rates in Zambia could provide a model for improved national and regional surveillance approaches, and...
Taking stock of SA's ART programme
In the course of human history, there have been very few medical interventions that have had as profound impact antiretroviral treatment (ART).
It’s easy to...
Injectable contraceptive may raise HIV infection risk by 40%
The injectable progestin contraceptive depot medroxyprogesterone acetate (DMPA) may raise the risk for HIV infection by 40% in women, according to a research review.
DMPA...
Immediate ART has little impact on risk
Starting antiretroviral therapy (ART) immediately rather waiting until a person's CD4 count falls below 500 cells/µL has almost no impact on the person's risk...
Diabetes in people with HIV over 50 linked to old ARVs
People with HIV over the age of 50 are more likely to have developed type 2 diabetes if they started antiretroviral treatment before 1999...
Challenging the dogma of genotype-defined resistance to ARVs
Genotype-defined resistance to antiretrovirals supposedly predicts future virological failure. Findings from clinical studies, including the 144-week results from the EARNEST trial, challenge this decades-long...
Drug combo effective and safe for first-time HIV treatment
The two-drug antiretroviral combination dolutegravir and lamivudine is virologically effective and safe in people starting HIV therapy for the first time, according to US...
Baseline CD4 count biggest factor in long-term immune improvement
Pre-treatment CD4 cell count is the most important factor in immune recovery following the initiation of combination antiretroviral therapy (cART), according to the results...
'Modest' lower risk of HIV treatment failure with fixed dose regimes
Research from the US and Europe has found that patients taking a single-tablet, fixed-dose combination (FDC) regime for HIV had a ‘modestly’ lower risk...
Progress on the 3rd 90-target not a reliable guide to transmission potential
Measuring the proportion of people with an undetectable viral load may be lulling health policymakers into a false sense of security in their efforts...
TDF/boosted protease inhibitor combination associated with higher CKD risk
The risk of chronic kidney disease (CKD) may be increased in patients living with HIV receiving tenofovir (TDF) with a ritonavir-boosted protease inhibitor compared...
Difficult to eliminate HIV with only straightforward treatment – study
A universal test-and-treat policy may sound like a solid route towards reducing the number of new HIV infections, but results of a major five-year...
HIV drug resistance approaching and exceeding 10%
HIV drug resistance is approaching and exceeding 10% in people living with HIV who are about to initiate or re-initiate first-line antiretroviral therapy, according...
Immediate ART after diagnosis improves retention
Starting antiretroviral therapy (ART) immediately following an HIV diagnosis dramatically improves retention in clinical HIV care, according to a study led by a Boston...
Proven HIV prevention measures reducing new infections
A Uganda study has provided real-world evidence that implementing a combination of proven HIV prevention measures across communities can substantially reduce new HIV infections...
The state of the global HIV and TB response as we move to the end of 2017
Great progress, but... An array of academics and activists take a snapshot of the state of the global response to HIV and TB.
“I am...
Not zero risk of onward transmission during breastfeeding
While effective HIV treatment greatly reduces the risk of onward transmission during breastfeeding, it does not appear that the risk is zero, a leading...
Three decades on, stigma still undermines HIV prevention and treatment
There have been great strides and many important victories in the fight against HIV. And, writes Linda-Gail Bekker, professor of medicine and deputy director...
Special journal issue on new approaches to treating HIV
Although some 19.5m HIV-infected people are receiving antiretroviral treatment, a substantial treatment gap leaves many millions of people at risk of Aids-related diseases and,...
No transmissions from breastfeeding in Tanzania cohort
No HIV exposed infants who were negative at birth, whose mothers started antiretroviral therapy (ART) before delivery, had suppressed viral loads and exclusively breastfed,...
Cognitive changes may occur early in patients on cART
Adults with human immunodeficiency virus (HIV) and good viral suppression on combination antiretroviral therapy had poorer cognition and reduced brain thickness and volume on...
Viral loads' study reveals new cohort at risk of therapy failure
In a large South African cohort study, a team of researchers from the University of the Witwatersrand (Johannesburg, Gauteng, South Africa) collaborating with the...
Dual-HIV-regimen found to be a simple, safe salvage therapy
The dual combination of dolutegravir (DTG) plus darunavir/ritonavir (DRV/r) provided a simple and safe salvage therapy to suppress viral replication without metabolic impact in...