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Oncology
Height should be considered a risk factor for colorectal screening – Meta-analysis
A meta-analysis by Johns Hopkins Medicine researchers adds to evidence that taller adults may be more likely than shorter ones to develop colorectal cancer...
Ultrasound scan versus MRI scans for prostate cancer – UK paired-cohort study
An ultrasound scan was able to diagnose most prostate cancer cases with good accuracy in a clinical trial involving 370 men, reports a study...
Enhertu improved progression-free and overall survival in metastatic breast cancer
The first HER2-low metastatic breast cancer Phase III results for AstraZeneca and Daiichi Sankyo’s Enhertu offer potential to redefine how the disease is classified...
Darolutamide improves survival in metastatic prostate cancer
Results from an international, randomised, double-blind, placebo-controlled, phase 3 clinical trial provide hope for men suffering from usually fatal metastatic hormone-sensitive prostate cancer. The...
Keytruda boosts event-free survival by up to 39% in early triple-negative breast cancer
In patients with early triple-negative breast cancer, pembrolizumab (Keytruda) with chemotherapy cuts recurrence by up to 39%, found a three-year follow-up of the Keynote-522 trial,...
Decade-long leukaemia remissions with CAR T-cell therapy – Landmark study
Two of the first human patients treated with a therapy that engineers immune cells to target specific types of cancer still possess cancer-killing cells...
Novel combination treatment improves survival in pancreatic cancer – Animal study
Mice with pancreatic tumours given a novel combination treatment lived 25% longer than those given just high intensity, focused ultrasound (HIFU), and 35% longer...
Oral anticoagulants decrease cancer-associated thrombosis – Mayo Clinic meta-analysis
Direct oral anticoagulants significantly decreased cancer-associated venous thrombosis recurrence without significantly increasing bleeding, found an ongoing Mayo Clinic study.
Thrombotic outcomes increase mortality in cancer...
Immunotherapy before liver cancer surgery kills tumours – Mount Sinai clinical trial
Immunotherapy given before surgery caused liver cancer tumours to die off in one-third of the patients enrolled in a first-of-its-kind clinical trial, Mount Sinai...
High coffee consumption associated with lower endometrial cancer risk – Meta-analysis
Higher coffee consumption is linked with a lower risk of endometrial cancer, a type of cancer that begins in the lining of uterus, according...
Inhaled CBD shrinks glioblastoma in animal model
Inhaled CBD (cannabidiol) shrinks the size of the highly aggressive, lethal brain tumour glioblastoma in an animal model by reducing the essential support of...
Severe outcomes in vaccinated cancer patients with breakthrough COVID
The first study to evaluate the clinical characteristics and outcomes of fully vaccinated patients with cancer who had breakthrough COVID-19 infections indicates they remained...
Glioblastoma: First trial for oral cannabinoids plus chemotherapy
Hundreds of cancer patients at 15 UK hospitals will be given Sativex, an oral spray containing cannabinoids, along with chemotherapy to treat their aggressive...
HPV vaccine cuts cervical cancer by nearly 90% — UK population registry study
The human papillomavirus (HPV) vaccine is cutting cervical cancer incidence by nearly 90%, the first real-world data from the UK, published in The Lancet,...
Inexpensive drug significantly enhanced radiation therapy effectiveness in brain metastases — Small trial
Treatment with arginine, one of the amino-acid building blocks of proteins, enhanced the effectiveness of radiation therapy in cancer patients with brain metastases, in...
Under-35s have greater risk of breast cancer spreading — Meta-analysis
Women under 35 diagnosed with breast cancer face a higher risk of it spreading, according to the first global study of its kind, presented...
Low glycaemic diet inhibits tumour growth in animal study
Calorie restriction, but not a ketogenic diet, inhibits the growth of tumours in a mouse model of pancreatic cancer, found a study in Nature.
Although...
Exercise may alleviate ‘chemo brain’ in breast cancer — Washington University study
Regular exercise may help lessen “chemo brain” among women being treated for breast cancer, according to a large-scale study of the associations between physical...
Adavosertib may delay tumour regrowth in inoperable metastatic colorectal cancer
Adavosertib, taken as a daily pill, may delay tumour regrowth among patients with an aggressive sub-type of inoperable metastatic colorectal cancer, found a UK...
ESMO 2021: Highly promising results against breast and ovarian cancer
AstraZeneca’s Enhertu demonstrated a 72% reduction in the risk of disease progression or death in HER2-positive metastatic breast cancer according to trial results presented...
Increased colon cancer risk extends to second- and third-degree relatives
Having second- or third-degree relatives with colorectal cancer significantly increases the risk of developing the disease, found a study in Cancer Epidemiology. Early screening...
Antibiotic use linked to increased risk of colon cancer — Swedish Colorectal Cancer Registry
There is a clear link between taking antibiotics for more than six months and an increased risk of developing colon cancer within the next...
Antibiotic use linked to increased risk of colon cancer — large Swedish analysis
There is a clear link between taking antibiotics and an increased risk of developing colon cancer within the next five to 19 years, found...
Statins may significantly improve survival in triple-negative breast cancer
A significant association was found between cholesterol-lowering drugs, commonly known as statins, and survival rates of triple-negative breast cancer patients, found a study led...
High Intensity Training regimen may inhibit prostate cancer growth — ERASE trial
Rigorous exercise not only boosted cardiorespiratory fitness, but also improved indicators of prostate cancer biochemical progression in patients undergoing active surveillance, according to results...
Statins may significantly improve survival in triple-negative breast cancer
A significant association was found between cholesterol-lowering drugs, commonly known as statins, and survival rates of triple-negative breast cancer patients, found a study led...
Vitamin D deficiency from inadequate sunlight may increase colorectal cancer risk
Inadequate exposure to UVB light from the sun may be associated with an increased risk of colorectal cancer, particularly in older age groups, according...
Hysterectomy plus chemo improves metastatic uterine cancer survival
Total abdominal hysterectomy (TAH), in addition to chemotherapy, significantly improved overall survival (OS) in patients with newly diagnosed uterine cancer and distant metastases, a...
Cancer Research UK: Progress at detecting glioma through urine
Cancer Research UK scientists report “very promising results” at detecting for the first time signs of glioma through urine, according to a study in...
NHS pilots simple blood test that screens for 50 types of cancer
A simple blood test that can detect more than 50 types of cancer in asymptomatic patients is accurate enough to be rolled out as...
‘Potential new standard’ in high-risk kidney cancer — KEYNOTE-564 trial
Single-agent immune checkpoint inhibition after surgery reduced the risk of disease recurrence or death in patients with high-risk clear cell renal cell carcinoma (RCC),...
Trials stopped early as benefits shown for olaparib in breast cancer
Women with hereditary breast cancer, triggered by the BRCA1 or BRCA2 genes, stand a better chance of survival following successful trials of a drug...
PARP inhibitor shrinks tumours in pancreatic cancer with mutations
More than two-thirds of pancreatic cancer patients harbouring genetic mutations saw their tumour stop growing or shrink substantially after being switched from intensive chemotherapy...
Sugary drinks associated with increased risk of colorectal cancer in women
Heavy consumption of sugary drinks during adolescence and adulthood is associated with an increased risk of developing colorectal cancer in women under age 50,...
An epidemiological insight into HPV status and prognostic gene mutations in head and neck cancer
A study release from Clarivate:
Summary
Since human papilloma virus (HPV) infection is related to sexual practices and HPV positive head and neck cancers (HNCs), particularly...
Immunotherapy combination shows early promise in glioblastoma
Immunotherapy together with an experimental cancer drug could offer a new way of treating some patients with aggressive brain cancers, promising early results from...
Bariatric surgery significantly cuts cancer risk in severely obese NAFLD patients
Bariatric surgery can significantly reduce the risk of cancer – and especially obesity-related cancers – by as much as half in certain individuals, according...
CT scan catches 70% of lung cancers at early stage — SUMMIT study
Giving smokers and ex-smokers a CT scan uncovers cancerous lung tumours when they are at an early enough stage so they can still be...
MRI improves detection of clinically significant prostate cancer — IP1-PROSTAGRAM study
MRI improved detection of clinically significant prostate cancer without increasing overdiagnosis compared with PSA testing, according to a prospective, population-based, blinded cohort study. The...
Pre-diagnosis aspirin use may lower colorectal cancer mortality — American Cancer Society
A study finds that long-term aspirin use before a diagnosis of colorectal cancer (CRC) may be associated with lower CRC-specific mortality, found an American...