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Increase in liver injury linked to herbal and dietary supplements — Australian study

The number of patients being admitted to hospital with severe liver injuries caused by herbal and dietary supplements claiming to promote muscle growth or weight loss is increasing, with some people harmed so severely they required a liver transplant, according to a small study in the Medical Journal of Australia.

Led by Dr Emily Nash from the Royal Prince Alfred Hospital, the study examined records of 184 adults admitted to the AW Morrow Gastroenterology and Liver Centre with drug-induced liver injury between 2009 and 2020. She and her co-authors found liver injury cases linked to herbal and dietary supplements increased from two out of 11 patients (15%) during 2009–11, to 10 out of 19 patients (47%) during 2018–20.

Liver injury from overdose from paracetamol, a widely used medication to treat fever and pain, and antibiotics, is common, and the authors found 115 patients with paracetamol-related drug-induced liver injury during the study period. Of the 69 with non-paracetamol liver injury, 19 cases involved antibiotics, 15 involved herbal and dietary supplements, and the rest involved anti-tuberculosis or anti-cancer medication.

Transplant-free survival was also worse for non-paracetamol liver injury, the study found. A co-author of the paper, specialist transplant hepatologist Dr Ken Liu, said he felt compelled to conduct the study because he was noticing more patients with liver injuries from drugs not typically associated with liver harm.

“I was starting to see injury in patients admitted with liver injury after using bodybuilding supplements for males or weight loss supplements in females,” he said. “I decided I should do a study on it to see if my hunch that more of these substances were causing these injuries was true.”

Liu and his colleagues said there needed to be more rigorous regulatory oversight for supplements and other alternative and natural therapies. They also noticed almost half the patients with supplement-induced severe liver injury had non-European ethnic backgrounds. Liu said more culturally appropriate community education about the risks of supplements was needed.

Dr Ken Harvey, public health physician and president of Friends of Science in Medicine, is quoted in The Guardian as saying that it was important to note that Liu’s study only examined the most severe cases of supplement-induced liver harm and that the actual rate of harm was possibly much higher.

“The study only examines severe cases admitted to a specialised liver unit; they cannot be extrapolated to the overall incidence of complementary medicine associated liver injury in Australia,” Harvey said.

In 2018, the drugs regulator, the Therapeutic Goods Administration (TGA), introduced the Therapeutic Goods (Permissible Indications) Determination. Manufacturers of complementary medicines could no longer make up their own list of benefits associated with their products, known as “indications”, but had to choose from a TGA-approved list.

“However, the natural and complementary therapy industry was allowed to create the list,” Harvey said. “This resulted in 86% of 1,021 permissible indications being justified by ‘traditional’ rather than ‘scientific’ evidence. This effectively removed the need for complementary medicines to have a scientific evidence base. Not surprisingly, the number of listed medicines claiming traditional use and containing herbal ingredients has increased.”

There is no pre-market evaluation by the TGA, Harvey said, and limited post-marketing surveillance shows a high level of regulatory non-compliance. “In addition, as the authors of the MJA paper point out, herbal and dietary supplements purchased online from overseas evade any Australian regulatory oversight,” he added.

“A low-risk product does not mean there is no risk. The TGA should conduct more post-marketing surveillance on listed products, especially Chinese traditional and Ayurveda medicines that have been associated with adverse events, contamination and adulteration. They should also publicise their findings.”

The Royal Australian College of General Practitioners, Choice (Australia’s leading consumer advocacy group), Friends of Science in Medicine and others have called for an educational statement on the pack and promotional material of medicines making traditional claims, for example saying ‘This product is based on traditional beliefs and not modern scientific evidence’.

“This was opposed by industry and the TGA,” Harvey said. “But it is still needed.”

Study details

Drug‐induced liver injury in Australia, 2009–2020: the increasing proportion of non‐paracetamol cases linked with herbal and dietary supplements

Emily Nash, Abdul‐Hamid Sabih, John Chetwood, Georgette Wood, Keval Pandya, Terry Yip, Avik Majumdar, Geoffrey W McCaughan, Simone I Strasser and Ken Liu

Published by The Medical Journal of Australia on 26 July 2021

Abstract

Objective
To compare the characteristics and outcomes of drug‐induced liver injury (DILI) caused by paracetamol and non‐paracetamol medications, particularly herbal and dietary supplements.

Design
Retrospective electronic medical record data analysis.

Setting, participants
Adults admitted with DILI to the Gastroenterology and Liver Centre at the Royal Prince Alfred Hospital, Sydney (a quaternary referral liver transplantation centre), 2009–2020.

Main outcome measures
90‐day transplant‐free survival; drugs implicated as causal agents in DILI.

Results
A total of 115 patients with paracetamol‐related DILI and 69 with non‐paracetamol DILI were admitted to our centre. The most frequently implicated non‐paracetamol medications were antibiotics (19, 28%), herbal and dietary supplements (15, 22%), anti‐tuberculosis medications (six, 9%), and anti‐cancer medications (five, 7%). The number of non‐paracetamol DILI admissions was similar across the study period, but the proportion linked with herbal and dietary supplements increased from 2 of 13 (15%) during 2009–11 to 9 of 19 (47%) during 2018–20 (linear trend: P = 0.011).

Despite higher median baseline model for end‐stage liver disease (MELD) scores, 90‐day transplant‐free survival for patients with paracetamol‐related DILI was higher than for patients with non‐paracetamol DILI (86%; 95% CI, 79–93% v 71%; 95% CI, 60–82%) and herbal and dietary supplement‐related cases (59%; 95% CI, 34–85%). MELD score was an independent predictor of poorer 90‐day transplant‐free survival in both paracetamol‐related (per point increase: adjusted hazard ratio [aHR], 1.19; 95% CI, 1.09–3.74) and non‐paracetamol DILI (aHR, 1.24; 95% CI, 1.14–1.36).

Conclusion
In our single centre study, the proportion of cases of people hospitalised with DILI linked with herbal and dietary supplements has increased since 2009. Ninety‐day transplant‐free survival for patients with non‐paracetamol DILI, especially those with supplement‐related DILI, is poorer than for those with paracetamol‐related DILI.

 

Medical Journal of Australia study – Drug‐induced liver injury in Australia, 2009–2020: the increasing proportion of non‐paracetamol cases linked with herbal and dietary supplements (Open access)

 

Full The Guardian report: Dietary supplements causing severe liver injuries in Australians, with some requiring transplants, study shows (Open access)

 

See more from MedicalBrief archives:

 

Threefold increase in liver damage from herbals and diet supplements

 

Potential for herbal medications to damage the liver

 

Supplement ingredients to steer clear of

 

Flawed dietary supplements lingering on US store shelves

 

The dietary supplement route to ER

 

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