South African guidelines recommend that pre-exposure prophylaxis (PrEP) should be considered for people who are HIV-negative and at significant risk of acquiring HIV infection. PrEP may be suitable for:
Any sexually active HIV-negative MSM or transgender person who wants PrEP
those with HIV-positive sexual partner(s) who are not confirmed virologically suppressed;
partner(s) of unknown HIV status;
recent STI;
multiple sexual partners;
history of inconsistent or no condom use;
commercial sex work;
recurrent PEP users;
history of sex whilst under the influence of alcohol or recreational drugs.
Heterosexual women and men who want PrEP, targeting especially
those with HIV-positive sexual partner(s) who are not confirmed virologically suppressed;
partner(s) of unknown HIV status;
recent STI;
multiple sexual partners;
history of inconsistent or no condom use;
commercial sex work;
serodiscordant couples trying to conceive;
recurrent PEP users;
history of sex whilst under the influence of alcohol or recreational drugs.
people who inject drugs
HIV-negative PWID with HIV-positive/unknown status injecting partner(s);
share injecting needles and drug preparation equipment.
All of the above groups include adolescents and sex workers, which each constitute special groups meriting specific consideration
Especially vulnerable are young MSM and adolescent girls.
[link url="https://www.prepwatch.org/country/south-africa/"]A snapshot of PrEP scale-up, registration and resources for South Africa[/link]