A respiratory virus that sometimes paralyses children is spreading across America, raising concerns about another possible rise in polio-like illnesses, according to US health officials.
NBC News reports that wastewater samples have detected a significant escalation in an enterovirus called D68, which, in rare cases, has been linked to acute flaccid myelitis (AFM). The illness affects the nervous system and causes severe weakness in the arms and legs – and often occurs in children.
“We are detecting EV-D68 nucleic acids in wastewater across the country now, and the levels are increasing,” said Alexandria Boehm, programme director of WastewaterSCAN, a non-profit monitoring network and a professor of civil and environmental engineering at Stanford University.
That’s the first clue to suggest that the US might see an increase in AFM this year, said Caitlin Rivers, an epidemiologist at the Johns Hopkins Centre for Health Security and author of Crisis Averted: The Hidden Science of Fighting Outbreaks.
“The second clue,” she said, “is that the time of year is right.” Historically, September has been the biggest month for AFM cases.
Anyone who’s ever had the sniffles probably had an enterovirus; they’re that common. Most of the time, the viruses cause mild symptoms, like a runny nose, cough, headache and generalised feelings of malaise.
The D68 enterovirus strain started causing more serious problems in 2014, when the US saw, for the first time, a spike in paediatric AFM. That year, 120 children were diagnosed.
There'’s no cure or specific treatment for the paralysis. Even with years of intensive physical therapy, many are left with life-altering disabilities.
A viral mystery
Though a few dozen cases have been reported every year since then, larger waves of AFM have followed an every-other-year pattern, spiking again in 2016 (with 153 cases) and in 2018 (with 238 cases).
The pattern stopped in 2020 when the US went into lockdown because of the Covid pandemic, drastically reducing viral spread. That year, just 32 cases were logged. The spread of D68 picked up again in 2022 as lockdowns were lifted.
Curiously, a rise in AFM cases didn’t follow.
“We saw the virus that was previously driving the AFM cases, but we didn’t see the AFM cases associated with it,” said Dr Kevin Messacar, an infectious disease specialist at Children’s Hospital Colorado, who treated some of the earliest AFM cases in 2014.
It’s a mystery that any virologist would appreciate. While experts try to predict how viruses will behave, the bugs are always working to stay a few steps ahead.
It could be that the virus itself has changed, or that more people in the US have been exposed and now have a level of immunity to D68. “We’re still trying to figure it out,” Messacar said.
So far this year, 13 AFM cases have been confirmed, according to the Centres for Disease Control and Prevention (CDC). Since 2014, 758 cases have been logged.
The implication is that hundreds of families and their children have been left with lasting, life-altering paralysis because of a virus.
Years of physical therapy
One of the first to be diagnosed in 2014 with AFM was Vishnu Kagolanu (now 14) from California. His head, inexplicably, started to tilt to one side, and within an hour, he had lost all ability to move his arms and legs.
“I couldn’t get myself off the floor,” he said.
At that time, no one had connected the dots between D68 and the “mystery illness”. “Even the doctors couldn’t find out what was going on,” said Saila Kagolanu, Vishnu’s mother.
Doctors warned the family that he might never regain function of his arms and legs. The prognosis crushed Vishnu, who was a keen sportsman.
He spent years undergoing physical therapy to regain the ability to walk. That was successful. Otherwise, there’s not much doctors can do. His right shoulder remains limp.
Testing a possible treatment
“We all get really frustrated every time we get to this point, and we don’t have antiviral medicines that are readily available,” said Dr Buddy Creech, a paediatric infectious disease physician at Vanderbilt University Medical Centre in Nashville. “We don’t have much to offer these children.”
Creech and his colleagues are working toward a solution. They’ve begun safety studies of a monoclonal antibody that would, ideally, stop D68 in its tracks.
“In mouse studies, it prevented infection that would lead to AFM,” Creech said. The study is expected to take years before the treatment is considered safe and effective.
Meanwhile, young people like Vishnu Kagolanu are attempting to move on and even inspire others with AFM. In recent years, he has started a non-profit group called Neurostronger, which works to raise funds for and increase awareness of kids with neurologic conditions.
See more from MedicalBrief archives:
EV-D68, the respiratory virus that can paralyse children
Viruses paused during COVID pandemic are on their way back
Results from 7-country project highlights the need for new vaccines