Saturday, 28 May, 2022
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Pulmonology

Good results from two-drug cystic fibrosis tx

Treatment with two medications that target the most common genetic cause of cystic fibrosis improves lung function and lowers the rate of pulmonary exacerbations, according to the results from a Phase III international clinical trial.

COPD sufferers face increased risk of SCD

Those with chronic obstructive pulmonary disease (COPD) have a 34% increased risk of sudden cardiac death (SCD) overall, but their risk almost doubles more than five years after first being diagnosed with COPD.

Protein may activate inflammatory response

A Northwestern Medicine study shows that a protein called vimentin may help activate an inflammatory response that leads to acute lung injury.

Higher lung cancer surgery risks than thought

Three presentations at the 95th Annual Meeting of the American Association for Thoracic Surgery suggest that lung cancer surgery patients are at higher risk of developing venous thrombo-embolism, including deep vein thrombosis and pulmonary embolism, than previously thought.

Adoption of LVRS for emphysema urged

Despite the the efficacy of lung volume reduction surgery (LVRS), its adoption for severe emphysema has been exceedingly poor. A new Columbia University study finds that minimally invasive LVRS can be performed with negligible surgical mortality risk.

Potential root cause of asthma found

Scientists have for the first time identified the potential root cause of asthma and an existing drug that offers a new treatment.

Steroids: 'Substantial' risk of adrenal malfunction

After stopping steroids commonly prescribed for asthma and allergies, a significant number of people may experience signs of malfunctioning in the adrenal glands, a European study finds.

Three-drug TB regimen shows promise

Dawson A new tuberculosis (TB) drug regimen designed to improve options for TB therapy eliminated more bacteria from sputum than standard therapy and did so at a faster rate, according to data from a phase 2b clinical trial in SA and Tanzania.

Stem cell 'mini lungs' aiding CF research

University of Cambridge scientists have successfully created 'mini-lungs' using stem cells derived from skin cells of patients with cystic fibrosis (CF), to test potential new drugs.

Bariatric surgery reduces asthma risk in obese

A study led by Massachusetts General Hospital (MGH) investigators suggests that bariatric surgery can significantly reduce the risk of asthma attacks in obese patients.

SA 'game-changer' in TB diagnosis

swabDrawing inspiration from veterinary medicine, researchers at the SA Tuberculosis Vaccine Initiative, the University of Cape Town and the University of Washington, have developed a new approach to detect tuberculosis (TB) – easy-to-obtain oral swab samples.

Molecule opens way to new TB treatments

Johns Hopkins researchers have uncovered how a bacterial molecule controls the body’s response to TB infection and suggest that adjusting the level of this molecule may be a new way to treat the disease.

XDR-TB not result of treatment failure

The vast majority of people with extensively drug-resistant tuberculosis (XDR-TB) have acquired their infection from another person, not as the result of the failure of treatment for multidrug-resistant strains of tuberculosis.

Trial asthma drug halves severe attacks

Clinical trials found that an investigational drug appears to halve the risk of severe asthma attacks in patients who have difficulty controlling the disorder with standard medications.

Gallopamil efficacy in severe asthma

French researchers have demonstrated the clinical efficacy of gallopamil in 31 patients with severe asthma, where it significantly reduced the bronchial smooth muscle mass and resulted in fewer prolonged attacks.

Corticosteroids supported for pneumonia

Spanish research determined that in community-acquire pneumonia patients there was two-thirds lower treatment failure from corticosteroid treatment than the placebo.

Cancer drugs could help treat TB

The same antiangiogenesis drugs that improved treatment of some cancers could help surmount persistent difficulties in treating tuberculosis (TB), according to investigators from the US National Institute of Allergies and Infectious Disease.

Common cold thrives in a cool nose

The common cold virus can reproduce itself more efficiently in the cooler temperature found inside the nose than at core body temperature, according to a new Yale-led study.

Medical student makes cystic fibrosis breakthrough

A medical student on work experience has made a breakthrough in cystic fibrosis research that will improve treatment and could extend sufferers’ life expectancy....