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Six distinct symptom clusters of COVID-19 identified — King's College London
Analysis of data from the COVID Symptom Study app, led by researchers from King’s College London, reveals that there are six distinct “types” of...
Three distinct immune responses for sicker COVID-19 patients — Penn Institute of Immunology
Researchers from the Penn Institute of Immunology have discovered three distinct immune responses to the SARS-CoV2 infection that could help predict the trajectory of...
UK herd immunity threshold and seasonal exposure — Oxford epidemiological study
The UK population may already have developed sufficient levels of herd immunity required to prevent a feared second wave of the coronavirus pandemic in...
Drug that calms 'cytokine storm’ linked to 45% lower risk of COVID-19 ventilator deaths
Critically ill COVID-19 patients who received a single dose of a drug that calms an overreacting immune system were 45% less likely to die...
No increased COVID-19 mortality for people with HIV — large US cohort analysis
An analysis of the largest cohort of people living with HIV in the US found that they were not more likely to contract the...
COVID-19 pneumonia patients improve with immunosuppressant — Small US observational study
Most patients hospitalised with COVID-19 (coronavirus) pneumonia experienced improvement after receiving a US Food and Drug Administration-approved drug normally given for rheumatoid arthritis, according...
Mask wearing effectiveness, including among asymptomatic COVID-19 carriers
The two hair stylists in Springfield, Missouri, broke the cardinal rule of infection control: STAT News reports that despite having respiratory symptoms, one went...
Heparin 'potentially blocks' COVID-19 — US laboratory study
A common drug, already approved by the US Food and Drug Administration (FDA), may also be a powerful tool in fighting COVID-19, according to...
SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers
Health-care workers (HCWs) are at high risk of developing COVID-19, and may themselves contribute to transmission. To evaluate these risks, we enrolled 200 patient-facing...
Small study shows treatment reducing odds of COVID-19 disease progression
Experts have cautiously welcomed the results of a small trial of a coronavirus treatment that has dramatically reduced the odds of hospitalised patients progressing...
Almost half of hospitalised COVID-19 patients show heart scan abnormalities — Global study
Almost half of COVID-19 patients who have been hospitalised show scan abnormalities that resemble the early stages of heart failure, a global research study...
Global review of BCG vaccine protection from severe COVID-19
A epidemiological evidence review suggests a negative association between national bacillus Calmette–Guérin (BCG) vaccination policy and the prevalence and mortality of coronavirus disease. However,...
Comprehensive review of COVID-19's extrapulmonary effects
After only a few days caring for critically ill COVID-19 patients at the start of the outbreak in New York City, Dr Aakriti Gupta,...
COVID-19 linked strokes more severe and have worse outcomes — Acute Stroke Registry
Acute ischaemic strokes (AIS) associated with COVID-19 are more severe, lead to worse functional outcomes and are associated with higher mortality, according to researchers...
Neurological complications linked to COVID-19 occurring globally — University of Liverpool review
A review by University of Liverpool researchers has shown that strokes, delirium and other brain complications are reported from most countries where there have...
Blacks at doubled higher risk for COVID-19 — University of Chicago analysis
Results of an analysis has found that Black individuals were twice as likely as White individuals to test positive for COVID-19. The average age...
Pre-clinical study supports remdesivir as COVID-19 treatment
The news about remdesivir, the investigational anti-viral drug that has shown early promise in the fight against COVID-19, keeps getting better. Researchers at Vanderbilt...
Hyperglycaemia link to higher COVID-19 mortality in those not previously diagnosed as diabetic
Research from Wuhan, China shows that, in patients with COVID-19 but without a previous diagnosis of diabetes, abnormally high blood sugar is associated with...
Persistence of at least one symptom in almost 90% of recovered COVID-19 Italian patients
In Italy, a large proportion of patients with coronavirus disease 2019 (COVID-19) presented with symptoms (71.4% of 31 845 confirmed cases as of 3 June,...
Older, critical COVID-19 patients may have increased risk of bradycardia with lopinavir and ritonavir
Older, critically ill patients with COVID-19 who received a combination of the antiretroviral medications lopinavir and ritonavir experienced bradycardia, a slow heart rate, more...
COVID-19 outcomes and immune function in people with HIV — NY cohort study
People living with HIV spent a similar amount of time in hospital as HIV-negative COVID-19 patients and had a comparable death rate during the...
Schools have not developed into hotspots — ongoing German study
The medical faculty of the TU Dresden and Dresden University Hospital Carl Gustav Carus started a study on the spread of the SARS-CoV-2 virus...
Prevalence of SARS-CoV-2 infection in Spain: Nationwide, population-based sero-epidemiological study
Summary
Background: Spain is one of the European countries most affected by the COVID-19 pandemic. Serological surveys are a valuable tool to assess the extent...
SARS-CoV-2 seroprevalence in COVID-19 hotspots – Lancet comment
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has surprised the world with its range of disease manifestations, from asymptomatic infection to critical illness leading...
National Institute of Allergy and Infectious Diseases-sponsored phase 1 trial tested mRNA vaccine
An investigational vaccine designed to protect against COVID-19 was generally well tolerated and prompted neutralising activity in healthy adults, according to interim results. The...
Comorbidities increase death risk twelvefold — US Centres for Disease Control
People with chronic health conditions such as heart disease and diabetes were hospitalised six times more often than otherwise healthy individuals infected with the...
Grave medical journal failures force peer review rethink
Some of the world’s leading medical journals are reviewing their processes after they were forced to retract major covid studies based on flawed data,...
Most first-wave COVID-19 clinical trials have 'major design shortcomings'
Most of the registered clinical trials of potential treatments for COVID-19 underway as of late March were designed in ways that will greatly limit...
Cape Town's BCG trials threatened by demands from advocacy group
A critical 500-person Cape Town trial, part of an international examination into whether the BCG vaccine protects against COVID-19, is under pressure from demands...
Authors say review linking vegetarianism and depression 'misinterpreted'
The nuance of a study showing a link between vegetarianism and poor mental health got lost as the study was shared widely online, reports...
Pandemic urgency sees peer review 'outsourced' to practising doctors and journalists
The COVID-19 pandemic has seen "droves of research papers rushed to pre-print servers, essentially outsourcing peer review to practising physicians and journalists", write ethicists...
Serological survey results trickling in but caution advised on interpretation
Results from the first studies designed to determine how widely the coronavirus has spread in communities have started to trickle in, drawing immense attention....
How important are the racial differences in COVID-19 data?
Claims that the racial disparities to be seen in US pandemic data evidence of are evidence of systemic racism rests on a false presumption,...
And why the sex differences in Covid-19 susceptibility?
Most day-to-day diseases don’t seem to care what sex you are: man or woman, those coughs, colds and stomach bugs latch on regardless. But,...
Minimising the effect of China's wet markets stems from a Western failing
The unwillingness of the authors of a recent study in Nature Medicine, to minimise moral or socio-political conclusions — in this case between Chinese...
WHO guidelines on wearing of masks: 'Yes, but…'
To wear or not to wear? That has become the key question during the pandemic as the face mask has become a symbol of...
Decisions on COVID-19 made without reliable evidence
A once-in-a-century pandemic. But, writes John PA Ioannidis, professor of medicine, of epidemiology and population health, of biomedical data science and of statistics at...
FDA authorises use of rapid COVID-19 diagnostic test
The US Food and Drug Administration issued the first emergency use authorisation for a point-of-care COVID-19 diagnostic for the Cepheid Xpert Xpress SARS-CoV-2 test....
COVID-19: Large China study finds children not exempt from falling seriously ill
The coronavirus raging around the globe has tended to tread gently with children, who account for the smallest percentage of the infections identified so...
Nurofen producer rejects French warnings that ibuprofen may worsen COVID-19
Nurofen producer Reckitt Benckiser sought to quash warnings against taking the drug, saying it was not aware of any evidence that the pills’ active...